Sinteza i karakterizacija kompleksa trifenilkalaja(IV) sa 2-(4- hidroksi-2-oksohinolinil)etanskom kiselinom

Abstract

U datom radu opisana je sinteza 2-(4-hidroksi-2-oksohinolinil)etanske kiseline i njenog kompleksa trifenilkalaja(IV). Ligand je dobijen hidrolizom metil-estra sintetisanog u reakciji između4-hidroksi-2-hinolona i metil-2-bromoetanoata. U reakciji deprotonovanog liganda i ekvimolarne količine Ph3SnCl dobijen je kompleks u obliku belog taloga. Sintetisana jedinjenja su okarakterisana standardnim analitičkim metodama. Naredna istraživanja sintetisanih jedinjenja biće usmerena ka ispitivanju antitumorske aktivnosti prema raznim ćelijskim linijama karcinoma.

Synthesis of 2-(4-methyl-2-oxoquinolinyl)ethanoic acid and its triphenyltin(IV) complex has been performed. The ligand has been obtained by the hydrolysis of methyl ester synthesized in the reaction between 4-hydroxy-2-quinolone and methyl 2-bromoethanoate. In the reaction of deprotonated ligand with equimolar amount of Ph3SnCl, the desired complex was precipitated as a white solid. The synthesized compounds have been characterized using standard analytical methods. The following research of synthesized compounds will be focused on examining their antitumor activity against various cancer cell lines.