Development of Green Chemical Process: The Reaction of Condensation in a Continuous Flow Microreactor System
Само за регистроване кориснике
2019
Аутори
Tadić, JulijanaSvetozarević, Milica
Dajić, Ana
Mihajlović, Marina
Jovanović, Mića
Mijin, Dušan
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Aromatic heterocyclic compounds containing nitrogen in their structure have attracted
considerable interest in medicine, because of their certain pharmacological properties
including anticancer, anti-inflammatory, antihypertensive, antibacterial, antifungal and
antiviral activities. Among them, derivatives with 2-pyridone moiety are particularly
notable due to their wide application in pharmacological and dye industry. A usual
procedure for synthesis of 2-pyridone moiety is classic condensation reaction of 1,3-
dicarbonyl compounds with cyanoacetamide. However, in the case of various
substituted reactants, drawback of this reaction can be a low yield of desirable products
and long reaction time. This factor has led to the development of different methods for
synthesis in order to overcome these defects. The microreactor technology and flow
chemistry could play a significant role in the improving of organic synthesis efficiency.
The microreactor approach could provide enhance...d productivity, fast conversion and
altogether less hazardous chemical synthesis. Furthermore, it pushes towards designing
of chemistry with a lower environmental and economic impact. In this study the
synthesis of 2-pyridone moiety in a continuous flow coil-type microreactor system was
examined. In order to optimize reaction conditions, flow rates of starting reagents were
varied. The desirable 2-pyridone was obtained in satisfactory yield of circa 60% in less
than 10 minutes. The structure and purity of synthetized 2-pyridone moiety were
confirmed by melting point, FT-IR, 1
H NMR and UV-Vis spectra. The efficiency of the
presented method for the synthesis of 2-pyridone based molecules has promising scaleup potential.
Кључне речи:
continuous flow synthesis / heterocycles / process intensificationИзвор:
Conference proceedings / International Scientific Conference Environmental Impact of Illegal Construction, Poor Planning and Design IMPEDE 2019, 10-11 October 2019, Belgrade, Serbia, 2019, 129-133Издавач:
- Belgrade : Association of Chemists and Chemical Engineers of Serbia UHTS
Финансирање / пројекти:
- Развој технолошких процеса за третман отпадних вода енергетских постројења применом чистије производње (RS-MESTD-Technological Development (TD or TR)-34009)
- Проучавање синтезе, структуре и активности органских једињења природног и синтетског порекла (RS-MESTD-Basic Research (BR or ON)-172013)
Колекције
Институција/група
Inovacioni centarTY - CONF AU - Tadić, Julijana AU - Svetozarević, Milica AU - Dajić, Ana AU - Mihajlović, Marina AU - Jovanović, Mića AU - Mijin, Dušan PY - 2019 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6909 AB - Aromatic heterocyclic compounds containing nitrogen in their structure have attracted considerable interest in medicine, because of their certain pharmacological properties including anticancer, anti-inflammatory, antihypertensive, antibacterial, antifungal and antiviral activities. Among them, derivatives with 2-pyridone moiety are particularly notable due to their wide application in pharmacological and dye industry. A usual procedure for synthesis of 2-pyridone moiety is classic condensation reaction of 1,3- dicarbonyl compounds with cyanoacetamide. However, in the case of various substituted reactants, drawback of this reaction can be a low yield of desirable products and long reaction time. This factor has led to the development of different methods for synthesis in order to overcome these defects. The microreactor technology and flow chemistry could play a significant role in the improving of organic synthesis efficiency. The microreactor approach could provide enhanced productivity, fast conversion and altogether less hazardous chemical synthesis. Furthermore, it pushes towards designing of chemistry with a lower environmental and economic impact. In this study the synthesis of 2-pyridone moiety in a continuous flow coil-type microreactor system was examined. In order to optimize reaction conditions, flow rates of starting reagents were varied. The desirable 2-pyridone was obtained in satisfactory yield of circa 60% in less than 10 minutes. The structure and purity of synthetized 2-pyridone moiety were confirmed by melting point, FT-IR, 1 H NMR and UV-Vis spectra. The efficiency of the presented method for the synthesis of 2-pyridone based molecules has promising scaleup potential. PB - Belgrade : Association of Chemists and Chemical Engineers of Serbia UHTS C3 - Conference proceedings / International Scientific Conference Environmental Impact of Illegal Construction, Poor Planning and Design IMPEDE 2019, 10-11 October 2019, Belgrade, Serbia T1 - Development of Green Chemical Process: The Reaction of Condensation in a Continuous Flow Microreactor System EP - 133 SP - 129 UR - https://hdl.handle.net/21.15107/rcub_technorep_6909 ER -
@conference{ author = "Tadić, Julijana and Svetozarević, Milica and Dajić, Ana and Mihajlović, Marina and Jovanović, Mića and Mijin, Dušan", year = "2019", abstract = "Aromatic heterocyclic compounds containing nitrogen in their structure have attracted considerable interest in medicine, because of their certain pharmacological properties including anticancer, anti-inflammatory, antihypertensive, antibacterial, antifungal and antiviral activities. Among them, derivatives with 2-pyridone moiety are particularly notable due to their wide application in pharmacological and dye industry. A usual procedure for synthesis of 2-pyridone moiety is classic condensation reaction of 1,3- dicarbonyl compounds with cyanoacetamide. However, in the case of various substituted reactants, drawback of this reaction can be a low yield of desirable products and long reaction time. This factor has led to the development of different methods for synthesis in order to overcome these defects. The microreactor technology and flow chemistry could play a significant role in the improving of organic synthesis efficiency. The microreactor approach could provide enhanced productivity, fast conversion and altogether less hazardous chemical synthesis. Furthermore, it pushes towards designing of chemistry with a lower environmental and economic impact. In this study the synthesis of 2-pyridone moiety in a continuous flow coil-type microreactor system was examined. In order to optimize reaction conditions, flow rates of starting reagents were varied. The desirable 2-pyridone was obtained in satisfactory yield of circa 60% in less than 10 minutes. The structure and purity of synthetized 2-pyridone moiety were confirmed by melting point, FT-IR, 1 H NMR and UV-Vis spectra. The efficiency of the presented method for the synthesis of 2-pyridone based molecules has promising scaleup potential.", publisher = "Belgrade : Association of Chemists and Chemical Engineers of Serbia UHTS", journal = "Conference proceedings / International Scientific Conference Environmental Impact of Illegal Construction, Poor Planning and Design IMPEDE 2019, 10-11 October 2019, Belgrade, Serbia", title = "Development of Green Chemical Process: The Reaction of Condensation in a Continuous Flow Microreactor System", pages = "133-129", url = "https://hdl.handle.net/21.15107/rcub_technorep_6909" }
Tadić, J., Svetozarević, M., Dajić, A., Mihajlović, M., Jovanović, M.,& Mijin, D.. (2019). Development of Green Chemical Process: The Reaction of Condensation in a Continuous Flow Microreactor System. in Conference proceedings / International Scientific Conference Environmental Impact of Illegal Construction, Poor Planning and Design IMPEDE 2019, 10-11 October 2019, Belgrade, Serbia Belgrade : Association of Chemists and Chemical Engineers of Serbia UHTS., 129-133. https://hdl.handle.net/21.15107/rcub_technorep_6909
Tadić J, Svetozarević M, Dajić A, Mihajlović M, Jovanović M, Mijin D. Development of Green Chemical Process: The Reaction of Condensation in a Continuous Flow Microreactor System. in Conference proceedings / International Scientific Conference Environmental Impact of Illegal Construction, Poor Planning and Design IMPEDE 2019, 10-11 October 2019, Belgrade, Serbia. 2019;:129-133. https://hdl.handle.net/21.15107/rcub_technorep_6909 .
Tadić, Julijana, Svetozarević, Milica, Dajić, Ana, Mihajlović, Marina, Jovanović, Mića, Mijin, Dušan, "Development of Green Chemical Process: The Reaction of Condensation in a Continuous Flow Microreactor System" in Conference proceedings / International Scientific Conference Environmental Impact of Illegal Construction, Poor Planning and Design IMPEDE 2019, 10-11 October 2019, Belgrade, Serbia (2019):129-133, https://hdl.handle.net/21.15107/rcub_technorep_6909 .