Biomechanical Aspects in Bone Tumor Engineering
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In the past decades, anticancer drug development brought the field of tumor engineering to a new level by the need of robust test systems. Simulating tumor microenvironment in vitro remains a challenge, and osteosarcoma—the most common primary bone cancer—is no exception. The growing evidence points to the inevitable connection between biomechanical stimuli and tumor chemosensitivity and aggressiveness, thus making this component of the microenvironment a mandatory requirement to the developed models. In this review, we addressed the question: is the “in vivo - in vitro” gap in osteosarcoma engineering bridged from the perspective of biomechanical stimuli? The most notable biomechanical cues in the tumor cell microenvironment are observed and compared in the contexts of in vivo conditions and engineered three-dimensional in vitro models.
Кључне речи:
3D in vitro models / bone cancer / bone tumor microenvironment / osteosarcomaИзвор:
Tissue Engineering - Part B: Reviews, 2023Издавач:
- Mary Ann Liebert Inc.
Финансирање / пројекти:
- European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement no. 860462 and the grant agreement no. 952033
DOI: 10.1089/ten.teb.2023.0106
ISSN: 1937-3368
PubMed: 37830183
Scopus: 2-s2.0-85179441743
Институција/група
Tehnološko-metalurški fakultetTY - JOUR AU - Menshikh, Ksenia AU - Banićević, Ivana AU - Obradović, Bojana AU - Rimondini, Lia PY - 2023 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7027 AB - In the past decades, anticancer drug development brought the field of tumor engineering to a new level by the need of robust test systems. Simulating tumor microenvironment in vitro remains a challenge, and osteosarcoma—the most common primary bone cancer—is no exception. The growing evidence points to the inevitable connection between biomechanical stimuli and tumor chemosensitivity and aggressiveness, thus making this component of the microenvironment a mandatory requirement to the developed models. In this review, we addressed the question: is the “in vivo - in vitro” gap in osteosarcoma engineering bridged from the perspective of biomechanical stimuli? The most notable biomechanical cues in the tumor cell microenvironment are observed and compared in the contexts of in vivo conditions and engineered three-dimensional in vitro models. PB - Mary Ann Liebert Inc. T2 - Tissue Engineering - Part B: Reviews T1 - Biomechanical Aspects in Bone Tumor Engineering DO - 10.1089/ten.teb.2023.0106 ER -
@article{ author = "Menshikh, Ksenia and Banićević, Ivana and Obradović, Bojana and Rimondini, Lia", year = "2023", abstract = "In the past decades, anticancer drug development brought the field of tumor engineering to a new level by the need of robust test systems. Simulating tumor microenvironment in vitro remains a challenge, and osteosarcoma—the most common primary bone cancer—is no exception. The growing evidence points to the inevitable connection between biomechanical stimuli and tumor chemosensitivity and aggressiveness, thus making this component of the microenvironment a mandatory requirement to the developed models. In this review, we addressed the question: is the “in vivo - in vitro” gap in osteosarcoma engineering bridged from the perspective of biomechanical stimuli? The most notable biomechanical cues in the tumor cell microenvironment are observed and compared in the contexts of in vivo conditions and engineered three-dimensional in vitro models.", publisher = "Mary Ann Liebert Inc.", journal = "Tissue Engineering - Part B: Reviews", title = "Biomechanical Aspects in Bone Tumor Engineering", doi = "10.1089/ten.teb.2023.0106" }
Menshikh, K., Banićević, I., Obradović, B.,& Rimondini, L.. (2023). Biomechanical Aspects in Bone Tumor Engineering. in Tissue Engineering - Part B: Reviews Mary Ann Liebert Inc... https://doi.org/10.1089/ten.teb.2023.0106
Menshikh K, Banićević I, Obradović B, Rimondini L. Biomechanical Aspects in Bone Tumor Engineering. in Tissue Engineering - Part B: Reviews. 2023;. doi:10.1089/ten.teb.2023.0106 .
Menshikh, Ksenia, Banićević, Ivana, Obradović, Bojana, Rimondini, Lia, "Biomechanical Aspects in Bone Tumor Engineering" in Tissue Engineering - Part B: Reviews (2023), https://doi.org/10.1089/ten.teb.2023.0106 . .