Chitosan-pectin multilayer coating with anthocyanin grape dye as pH indicating wound dressing: Synthesis and characterization
Аутори
Petkovska, JovanaGeskovski, Nikola
Marković, Darka
Dimova, Vesna
Mirakovski, Dejan
Radetić, Maja
Jordanov, Igor
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Environmentally benign pH-indicating wound dressing comprised of carbohydrates chitosan (CH) and pectin (P), and anthocyanin grape (AG) dye is created via layer-by-layer assembly. Cotton fabric coated with eight bilayers of (CH-AG)4/(P-AG)4 deposited 1.97 % AG-dye. It exhibited a visible and immediate color change from pink to violet-blue while increasing its pH value from 6 to pH 7, matching the turning pH point of healing into an infected wound. Color transition of AG-dye in water-based buffers, tested by VIS-spectroscopy, shows the same color change when the pH value increased from 6 to 7. This coating imparts excellent antimicrobial activity against Gram-positive bacteria Staphylococcus aureus and yeast Candida albicans, moderate antibacterial activity against Gram-negative Escherichia coli bacteria, and no cytotoxicity on human fibroblast cells (MRC-5). This research proposes a sustainable, low-cost, and simple method for obtaining smart wound dressing that provides real-time moni...toring of the wound pH.
Кључне речи:
Anthocyanin grape dye / Antifungal property / Antimicrobial activity / Humanfibroblast cells / Layer-by-layer coated cotton fabric / Smart wound dressingИзвор:
Carbohydrate Polymer Technologies and Applications, 01-2024, 7, 100438-Издавач:
- Elsevier Ltd.
Колекције
Институција/група
Inovacioni centarTY - JOUR AU - Petkovska, Jovana AU - Geskovski, Nikola AU - Marković, Darka AU - Dimova, Vesna AU - Mirakovski, Dejan AU - Radetić, Maja AU - Jordanov, Igor PY - 2024-01 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7155 AB - Environmentally benign pH-indicating wound dressing comprised of carbohydrates chitosan (CH) and pectin (P), and anthocyanin grape (AG) dye is created via layer-by-layer assembly. Cotton fabric coated with eight bilayers of (CH-AG)4/(P-AG)4 deposited 1.97 % AG-dye. It exhibited a visible and immediate color change from pink to violet-blue while increasing its pH value from 6 to pH 7, matching the turning pH point of healing into an infected wound. Color transition of AG-dye in water-based buffers, tested by VIS-spectroscopy, shows the same color change when the pH value increased from 6 to 7. This coating imparts excellent antimicrobial activity against Gram-positive bacteria Staphylococcus aureus and yeast Candida albicans, moderate antibacterial activity against Gram-negative Escherichia coli bacteria, and no cytotoxicity on human fibroblast cells (MRC-5). This research proposes a sustainable, low-cost, and simple method for obtaining smart wound dressing that provides real-time monitoring of the wound pH. PB - Elsevier Ltd. T2 - Carbohydrate Polymer Technologies and Applications T1 - Chitosan-pectin multilayer coating with anthocyanin grape dye as pH indicating wound dressing: Synthesis and characterization SP - 100438 VL - 7 DO - 10.1016/j.carpta.2024.100438 ER -
@article{ author = "Petkovska, Jovana and Geskovski, Nikola and Marković, Darka and Dimova, Vesna and Mirakovski, Dejan and Radetić, Maja and Jordanov, Igor", year = "2024-01", abstract = "Environmentally benign pH-indicating wound dressing comprised of carbohydrates chitosan (CH) and pectin (P), and anthocyanin grape (AG) dye is created via layer-by-layer assembly. Cotton fabric coated with eight bilayers of (CH-AG)4/(P-AG)4 deposited 1.97 % AG-dye. It exhibited a visible and immediate color change from pink to violet-blue while increasing its pH value from 6 to pH 7, matching the turning pH point of healing into an infected wound. Color transition of AG-dye in water-based buffers, tested by VIS-spectroscopy, shows the same color change when the pH value increased from 6 to 7. This coating imparts excellent antimicrobial activity against Gram-positive bacteria Staphylococcus aureus and yeast Candida albicans, moderate antibacterial activity against Gram-negative Escherichia coli bacteria, and no cytotoxicity on human fibroblast cells (MRC-5). This research proposes a sustainable, low-cost, and simple method for obtaining smart wound dressing that provides real-time monitoring of the wound pH.", publisher = "Elsevier Ltd.", journal = "Carbohydrate Polymer Technologies and Applications", title = "Chitosan-pectin multilayer coating with anthocyanin grape dye as pH indicating wound dressing: Synthesis and characterization", pages = "100438", volume = "7", doi = "10.1016/j.carpta.2024.100438" }
Petkovska, J., Geskovski, N., Marković, D., Dimova, V., Mirakovski, D., Radetić, M.,& Jordanov, I.. (2024-01). Chitosan-pectin multilayer coating with anthocyanin grape dye as pH indicating wound dressing: Synthesis and characterization. in Carbohydrate Polymer Technologies and Applications Elsevier Ltd.., 7, 100438. https://doi.org/10.1016/j.carpta.2024.100438
Petkovska J, Geskovski N, Marković D, Dimova V, Mirakovski D, Radetić M, Jordanov I. Chitosan-pectin multilayer coating with anthocyanin grape dye as pH indicating wound dressing: Synthesis and characterization. in Carbohydrate Polymer Technologies and Applications. 2024;7:100438. doi:10.1016/j.carpta.2024.100438 .
Petkovska, Jovana, Geskovski, Nikola, Marković, Darka, Dimova, Vesna, Mirakovski, Dejan, Radetić, Maja, Jordanov, Igor, "Chitosan-pectin multilayer coating with anthocyanin grape dye as pH indicating wound dressing: Synthesis and characterization" in Carbohydrate Polymer Technologies and Applications, 7 (2024-01):100438, https://doi.org/10.1016/j.carpta.2024.100438 . .