Intraoral administration of probiotics and postbiotics: An overview of microorganisms and formulation strategies
Authors
Bogdanović, MihajloMladenović, Dragana
Mojović, Ljiljana
Đuriš, Jelena
Đukić-Vuković, Aleksandra
Article (Published version)
Metadata
Show full item recordAbstract
The last decade provided significant advances in the understanding of microbiota and its role in human health. Probiotics are live microorganisms with proven benefits for the host and were mostly studied in the context of gut health, but they can also confer significant benefits for oral health, mainly in the treatment of gingivitis. Postbiotics are cell-free extracts and metabolites of microorganisms which can provide additional preventive and therapeutic value for human health. This opens opportunities for new preventive or therapeutic formulations for oral administration. The microorganisms that colonize the oral cavity, their role in oral health and disease, as well as the probiotics and postbiotics which could have beneficial effects in this complex environment were discussed. The aim of this study was to review, analyse and discuss novel probiotic and postbiotic formulations intended for oral administration that could be of great preventive and therapeutic importance. A special a...ttention has been put on the formulation of the pharmaceutical dosage forms that are expected to provide new benefits for the patients and technological advantages relevant for industry. An adequate dosage form could significantly enhance the efficiency of these products.
Keywords:
Ligilactobacillus salivarius / Oral dosage forms / Oral microbiota / Postbiotics / ProbioticsSource:
Brazilian Journal of Pharmaceutical Sciences, 2024, 60, e23272-Publisher:
- Faculty of Pharmaceutical Sciences of the University of São Paulo
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200287 (Innovation Center of the Faculty of Technology and Metallurgy) (RS-MESTD-inst-2020-200287)
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200135 (University of Belgrade, Faculty of Technology and Metallurgy) (RS-MESTD-inst-2020-200135)
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200161 (University of Belgrade, Faculty of Pharmacy) (RS-MESTD-inst-2020-200161)
- Alliance of International Science Organizations, project SparkGREEN (ANSO-CR-PP 2022-08)
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Institution/Community
Tehnološko-metalurški fakultetTY - JOUR AU - Bogdanović, Mihajlo AU - Mladenović, Dragana AU - Mojović, Ljiljana AU - Đuriš, Jelena AU - Đukić-Vuković, Aleksandra PY - 2024 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7346 AB - The last decade provided significant advances in the understanding of microbiota and its role in human health. Probiotics are live microorganisms with proven benefits for the host and were mostly studied in the context of gut health, but they can also confer significant benefits for oral health, mainly in the treatment of gingivitis. Postbiotics are cell-free extracts and metabolites of microorganisms which can provide additional preventive and therapeutic value for human health. This opens opportunities for new preventive or therapeutic formulations for oral administration. The microorganisms that colonize the oral cavity, their role in oral health and disease, as well as the probiotics and postbiotics which could have beneficial effects in this complex environment were discussed. The aim of this study was to review, analyse and discuss novel probiotic and postbiotic formulations intended for oral administration that could be of great preventive and therapeutic importance. A special attention has been put on the formulation of the pharmaceutical dosage forms that are expected to provide new benefits for the patients and technological advantages relevant for industry. An adequate dosage form could significantly enhance the efficiency of these products. PB - Faculty of Pharmaceutical Sciences of the University of São Paulo T2 - Brazilian Journal of Pharmaceutical Sciences T1 - Intraoral administration of probiotics and postbiotics: An overview of microorganisms and formulation strategies SP - e23272 VL - 60 DO - 10.1590/s2175-97902024e23272 ER -
@article{ author = "Bogdanović, Mihajlo and Mladenović, Dragana and Mojović, Ljiljana and Đuriš, Jelena and Đukić-Vuković, Aleksandra", year = "2024", abstract = "The last decade provided significant advances in the understanding of microbiota and its role in human health. Probiotics are live microorganisms with proven benefits for the host and were mostly studied in the context of gut health, but they can also confer significant benefits for oral health, mainly in the treatment of gingivitis. Postbiotics are cell-free extracts and metabolites of microorganisms which can provide additional preventive and therapeutic value for human health. This opens opportunities for new preventive or therapeutic formulations for oral administration. The microorganisms that colonize the oral cavity, their role in oral health and disease, as well as the probiotics and postbiotics which could have beneficial effects in this complex environment were discussed. The aim of this study was to review, analyse and discuss novel probiotic and postbiotic formulations intended for oral administration that could be of great preventive and therapeutic importance. A special attention has been put on the formulation of the pharmaceutical dosage forms that are expected to provide new benefits for the patients and technological advantages relevant for industry. An adequate dosage form could significantly enhance the efficiency of these products.", publisher = "Faculty of Pharmaceutical Sciences of the University of São Paulo", journal = "Brazilian Journal of Pharmaceutical Sciences", title = "Intraoral administration of probiotics and postbiotics: An overview of microorganisms and formulation strategies", pages = "e23272", volume = "60", doi = "10.1590/s2175-97902024e23272" }
Bogdanović, M., Mladenović, D., Mojović, L., Đuriš, J.,& Đukić-Vuković, A.. (2024). Intraoral administration of probiotics and postbiotics: An overview of microorganisms and formulation strategies. in Brazilian Journal of Pharmaceutical Sciences Faculty of Pharmaceutical Sciences of the University of São Paulo., 60, e23272. https://doi.org/10.1590/s2175-97902024e23272
Bogdanović M, Mladenović D, Mojović L, Đuriš J, Đukić-Vuković A. Intraoral administration of probiotics and postbiotics: An overview of microorganisms and formulation strategies. in Brazilian Journal of Pharmaceutical Sciences. 2024;60:e23272. doi:10.1590/s2175-97902024e23272 .
Bogdanović, Mihajlo, Mladenović, Dragana, Mojović, Ljiljana, Đuriš, Jelena, Đukić-Vuković, Aleksandra, "Intraoral administration of probiotics and postbiotics: An overview of microorganisms and formulation strategies" in Brazilian Journal of Pharmaceutical Sciences, 60 (2024):e23272, https://doi.org/10.1590/s2175-97902024e23272 . .