Promising Hydroxyapatite/Nifuroksazid Conjugate
Аутори
Radovanović, ŽeljkoMihajlovski, Katarina
Radovanović, Lidija
Petrović, Rada
Janaćković, Đorđe
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The synergistic effect of two materials is a desirable phenomenon when designing a conjugate
material. Synthetic Hydroxyapatite (HAp, Ca10(PO4)6(OH)2) is very similar to the inorganic part of
bones and teeth of mammals. It is a well-known biomaterial with good biocompatibility,
osteoconductivity and bioactivity. Nifuroxazide (NFX, C12H9N3O5) is a broad-spectrum antibacterial
drug and poorly soluble in water. Nano HAp and NFX were mixed and homogenized in rotovapor
giving as a result HAp/NFX conjugate. All materials were analyzed by Fourier transform infrared
spectroscopy (FTIR), Field emission scanning electron microscopy (FESEM), X-Ray diffraction
(XRD), Thermogravimetry (TG) and Brunauer–Emmett–Teller (BET) method. The in vitro
antibacterial activities of HAp, NFX and HAp/NFX were examined against Gram-positive bacteria
Staphylococcus aureus, Gram-negative bacteria Escherichia coli and yeast Candida albicans. In vitro
drug release in simulated stomach acid and intestinal fl...uid showed a much faster release of NFX from
HAp surface than those of raw drug. Afore mentioned analyses showed the unique properties of the
HAp/NFX conjugate and introduced it as particularly prominent drug carrier.
Кључне речи:
Hydroxyapatite / Conjugate / In vitro drug releaseИзвор:
Programme and the Book of abstracts / Twenty-second Annual Conference YUCOMAT 2021 Herceg Novi, Montenegro, August 30 - September 3, 2021, 2021, 126-Издавач:
- Belgrade : Materials Research Society of Serbia
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200287 (Иновациони центар Технолошко-металуршког факултета у Београду доо) (RS-MESTD-inst-2020-200287)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200135 (Универзитет у Београду, Технолошко-металуршки факултет) (RS-MESTD-inst-2020-200135)
Колекције
Институција/група
Inovacioni centarTY - CONF AU - Radovanović, Željko AU - Mihajlovski, Katarina AU - Radovanović, Lidija AU - Petrović, Rada AU - Janaćković, Đorđe PY - 2021 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7399 AB - The synergistic effect of two materials is a desirable phenomenon when designing a conjugate material. Synthetic Hydroxyapatite (HAp, Ca10(PO4)6(OH)2) is very similar to the inorganic part of bones and teeth of mammals. It is a well-known biomaterial with good biocompatibility, osteoconductivity and bioactivity. Nifuroxazide (NFX, C12H9N3O5) is a broad-spectrum antibacterial drug and poorly soluble in water. Nano HAp and NFX were mixed and homogenized in rotovapor giving as a result HAp/NFX conjugate. All materials were analyzed by Fourier transform infrared spectroscopy (FTIR), Field emission scanning electron microscopy (FESEM), X-Ray diffraction (XRD), Thermogravimetry (TG) and Brunauer–Emmett–Teller (BET) method. The in vitro antibacterial activities of HAp, NFX and HAp/NFX were examined against Gram-positive bacteria Staphylococcus aureus, Gram-negative bacteria Escherichia coli and yeast Candida albicans. In vitro drug release in simulated stomach acid and intestinal fluid showed a much faster release of NFX from HAp surface than those of raw drug. Afore mentioned analyses showed the unique properties of the HAp/NFX conjugate and introduced it as particularly prominent drug carrier. PB - Belgrade : Materials Research Society of Serbia C3 - Programme and the Book of abstracts / Twenty-second Annual Conference YUCOMAT 2021 Herceg Novi, Montenegro, August 30 - September 3, 2021 T1 - Promising Hydroxyapatite/Nifuroksazid Conjugate SP - 126 UR - https://hdl.handle.net/21.15107/rcub_technorep_7399 ER -
@conference{ author = "Radovanović, Željko and Mihajlovski, Katarina and Radovanović, Lidija and Petrović, Rada and Janaćković, Đorđe", year = "2021", abstract = "The synergistic effect of two materials is a desirable phenomenon when designing a conjugate material. Synthetic Hydroxyapatite (HAp, Ca10(PO4)6(OH)2) is very similar to the inorganic part of bones and teeth of mammals. It is a well-known biomaterial with good biocompatibility, osteoconductivity and bioactivity. Nifuroxazide (NFX, C12H9N3O5) is a broad-spectrum antibacterial drug and poorly soluble in water. Nano HAp and NFX were mixed and homogenized in rotovapor giving as a result HAp/NFX conjugate. All materials were analyzed by Fourier transform infrared spectroscopy (FTIR), Field emission scanning electron microscopy (FESEM), X-Ray diffraction (XRD), Thermogravimetry (TG) and Brunauer–Emmett–Teller (BET) method. The in vitro antibacterial activities of HAp, NFX and HAp/NFX were examined against Gram-positive bacteria Staphylococcus aureus, Gram-negative bacteria Escherichia coli and yeast Candida albicans. In vitro drug release in simulated stomach acid and intestinal fluid showed a much faster release of NFX from HAp surface than those of raw drug. Afore mentioned analyses showed the unique properties of the HAp/NFX conjugate and introduced it as particularly prominent drug carrier.", publisher = "Belgrade : Materials Research Society of Serbia", journal = "Programme and the Book of abstracts / Twenty-second Annual Conference YUCOMAT 2021 Herceg Novi, Montenegro, August 30 - September 3, 2021", title = "Promising Hydroxyapatite/Nifuroksazid Conjugate", pages = "126", url = "https://hdl.handle.net/21.15107/rcub_technorep_7399" }
Radovanović, Ž., Mihajlovski, K., Radovanović, L., Petrović, R.,& Janaćković, Đ.. (2021). Promising Hydroxyapatite/Nifuroksazid Conjugate. in Programme and the Book of abstracts / Twenty-second Annual Conference YUCOMAT 2021 Herceg Novi, Montenegro, August 30 - September 3, 2021 Belgrade : Materials Research Society of Serbia., 126. https://hdl.handle.net/21.15107/rcub_technorep_7399
Radovanović Ž, Mihajlovski K, Radovanović L, Petrović R, Janaćković Đ. Promising Hydroxyapatite/Nifuroksazid Conjugate. in Programme and the Book of abstracts / Twenty-second Annual Conference YUCOMAT 2021 Herceg Novi, Montenegro, August 30 - September 3, 2021. 2021;:126. https://hdl.handle.net/21.15107/rcub_technorep_7399 .
Radovanović, Željko, Mihajlovski, Katarina, Radovanović, Lidija, Petrović, Rada, Janaćković, Đorđe, "Promising Hydroxyapatite/Nifuroksazid Conjugate" in Programme and the Book of abstracts / Twenty-second Annual Conference YUCOMAT 2021 Herceg Novi, Montenegro, August 30 - September 3, 2021 (2021):126, https://hdl.handle.net/21.15107/rcub_technorep_7399 .