Characterization and drug release of Zn-Al layered double hydroxyde-nifuroxazide composite
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
During last decades, layered double hydroxides ([MII1−xMIIIx(OH)2]x+(A−)x/n·yH2O, LDHs) have been used in catalysis, ceramics as well as in removal of anionic pollutants. Due to their excellent anion exchange capacity, good biocompatibility and low toxicity, the nanoparticles of LDHs showed an excellent potential as drug carriers. Nifuroxazide (C12H9N3O5, NFX) is a broad-spectrum antibacterial drug, poorly soluble in water. Towards to increase the solubility of NFX, Zn-Al-LDH/NFX composite has been prepared by precipitation method at room temperture. Zn-Al-LDH, NFX and the obtained composite were analyzed by Fourier transform infrared spectroscopy (FTIR), field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD), simultaneous thermogravimetry-differential thermal analysis (TG-DTA) and Brunauer–Emmett–Teller (BET) method. Characterization of the raw materials and the obtained composite confirmed the intercalation of NFX in Zn-Al-LDH. The in vitro study of drug release... in simulated stomach acid and intestinal fluid showed constant release of NFX from Zn-Al-LDH during 24 h, confirming Zn-Al-LDH is a promising drug carrier.
Кључне речи:
Zn-Al layered double hydroxyde / Nifuroxazide / composite / drug releaseИзвор:
Programme and The Book of Abstracts / Twenty-third Annual Conference YUCOMAT 2022 & Twelfth World Round Table Conference on Sintering XII WRTCS 2022, Herceg Novi, Montenegro, August 29 - September 2, 2022, 2022, 150-Издавач:
- Belgrade : Materials Research Society of Serbia
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200287 (Иновациони центар Технолошко-металуршког факултета у Београду доо) (RS-MESTD-inst-2020-200287)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200135 (Универзитет у Београду, Технолошко-металуршки факултет) (RS-MESTD-inst-2020-200135)
Колекције
Институција/група
Inovacioni centarTY - CONF AU - Radovanović, Željko AU - Radovanović, Lidija AU - Janaćković, Đorđe AU - Petrović, Rada PY - 2022 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7400 AB - During last decades, layered double hydroxides ([MII1−xMIIIx(OH)2]x+(A−)x/n·yH2O, LDHs) have been used in catalysis, ceramics as well as in removal of anionic pollutants. Due to their excellent anion exchange capacity, good biocompatibility and low toxicity, the nanoparticles of LDHs showed an excellent potential as drug carriers. Nifuroxazide (C12H9N3O5, NFX) is a broad-spectrum antibacterial drug, poorly soluble in water. Towards to increase the solubility of NFX, Zn-Al-LDH/NFX composite has been prepared by precipitation method at room temperture. Zn-Al-LDH, NFX and the obtained composite were analyzed by Fourier transform infrared spectroscopy (FTIR), field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD), simultaneous thermogravimetry-differential thermal analysis (TG-DTA) and Brunauer–Emmett–Teller (BET) method. Characterization of the raw materials and the obtained composite confirmed the intercalation of NFX in Zn-Al-LDH. The in vitro study of drug release in simulated stomach acid and intestinal fluid showed constant release of NFX from Zn-Al-LDH during 24 h, confirming Zn-Al-LDH is a promising drug carrier. PB - Belgrade : Materials Research Society of Serbia C3 - Programme and The Book of Abstracts / Twenty-third Annual Conference YUCOMAT 2022 & Twelfth World Round Table Conference on Sintering XII WRTCS 2022, Herceg Novi, Montenegro, August 29 - September 2, 2022 T1 - Characterization and drug release of Zn-Al layered double hydroxyde-nifuroxazide composite SP - 150 UR - https://hdl.handle.net/21.15107/rcub_technorep_7400 ER -
@conference{ author = "Radovanović, Željko and Radovanović, Lidija and Janaćković, Đorđe and Petrović, Rada", year = "2022", abstract = "During last decades, layered double hydroxides ([MII1−xMIIIx(OH)2]x+(A−)x/n·yH2O, LDHs) have been used in catalysis, ceramics as well as in removal of anionic pollutants. Due to their excellent anion exchange capacity, good biocompatibility and low toxicity, the nanoparticles of LDHs showed an excellent potential as drug carriers. Nifuroxazide (C12H9N3O5, NFX) is a broad-spectrum antibacterial drug, poorly soluble in water. Towards to increase the solubility of NFX, Zn-Al-LDH/NFX composite has been prepared by precipitation method at room temperture. Zn-Al-LDH, NFX and the obtained composite were analyzed by Fourier transform infrared spectroscopy (FTIR), field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD), simultaneous thermogravimetry-differential thermal analysis (TG-DTA) and Brunauer–Emmett–Teller (BET) method. Characterization of the raw materials and the obtained composite confirmed the intercalation of NFX in Zn-Al-LDH. The in vitro study of drug release in simulated stomach acid and intestinal fluid showed constant release of NFX from Zn-Al-LDH during 24 h, confirming Zn-Al-LDH is a promising drug carrier.", publisher = "Belgrade : Materials Research Society of Serbia", journal = "Programme and The Book of Abstracts / Twenty-third Annual Conference YUCOMAT 2022 & Twelfth World Round Table Conference on Sintering XII WRTCS 2022, Herceg Novi, Montenegro, August 29 - September 2, 2022", title = "Characterization and drug release of Zn-Al layered double hydroxyde-nifuroxazide composite", pages = "150", url = "https://hdl.handle.net/21.15107/rcub_technorep_7400" }
Radovanović, Ž., Radovanović, L., Janaćković, Đ.,& Petrović, R.. (2022). Characterization and drug release of Zn-Al layered double hydroxyde-nifuroxazide composite. in Programme and The Book of Abstracts / Twenty-third Annual Conference YUCOMAT 2022 & Twelfth World Round Table Conference on Sintering XII WRTCS 2022, Herceg Novi, Montenegro, August 29 - September 2, 2022 Belgrade : Materials Research Society of Serbia., 150. https://hdl.handle.net/21.15107/rcub_technorep_7400
Radovanović Ž, Radovanović L, Janaćković Đ, Petrović R. Characterization and drug release of Zn-Al layered double hydroxyde-nifuroxazide composite. in Programme and The Book of Abstracts / Twenty-third Annual Conference YUCOMAT 2022 & Twelfth World Round Table Conference on Sintering XII WRTCS 2022, Herceg Novi, Montenegro, August 29 - September 2, 2022. 2022;:150. https://hdl.handle.net/21.15107/rcub_technorep_7400 .
Radovanović, Željko, Radovanović, Lidija, Janaćković, Đorđe, Petrović, Rada, "Characterization and drug release of Zn-Al layered double hydroxyde-nifuroxazide composite" in Programme and The Book of Abstracts / Twenty-third Annual Conference YUCOMAT 2022 & Twelfth World Round Table Conference on Sintering XII WRTCS 2022, Herceg Novi, Montenegro, August 29 - September 2, 2022 (2022):150, https://hdl.handle.net/21.15107/rcub_technorep_7400 .