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dc.creatorAvramov-Ivić, Milka
dc.creatorPetrović, Slobodan
dc.creatorKalman, E
dc.creatorMilosavljević, T
dc.creatorReljin, Irini S.
dc.creatorReljin, Branimir D.
dc.creatorBogdanović, G.
dc.creatorBaltić, VV
dc.creatorKeresztes, Z
dc.date.accessioned2021-03-10T10:28:08Z
dc.date.available2021-03-10T10:28:08Z
dc.date.issued2005
dc.identifier.issn0352-5139
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/854
dc.description.abstractAtomic force microscopy (AFM), a unique tool to investigate drug treatment of cancer cells, was used to analyze the anti-neoplastic activity of adriamycin by comparing DNA structures of non-treated and adriamycin-treated Ehrlich tumor cells. The non-treated cells exhibited a highly branched intact chromatin structure, related to the intensive DNA replication in cancer cells. Images from adriamycin-treated tumor cells showed that the DNA chains were broken and the chromatin structure had been destroyed. Possible explanations for these effects of adriamycin are considered: breakage of hydrogen bonding, oxidation and intercalation effects, as well as the poisoning of topoisomerase enzyme. DNA fractal and multifractal analyses, performed in order to evaluate the degree of bond scission, showed that the treated DNA had become more fractal compared to non-treated DNA.en
dc.publisherSrpsko hemijsko društvo, Beograd
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceJournal of the Serbian Chemical Society
dc.subjectadriamycinen
dc.subjectEhrlich tumor cellsen
dc.subjectatomic force microscopyen
dc.subjecttopoisomeraseen
dc.subjectfractal and multifractal analysisen
dc.titleAFM studies of DNA structures extracted from adriamycin treated and non-treated Ehrlich tumor cellsen
dc.typearticle
dc.rights.licenseBY-NC-ND
dc.citation.epage831
dc.citation.issue6
dc.citation.other70(6): 823-831
dc.citation.rankM23
dc.citation.spage823
dc.citation.volume70
dc.identifier.doi10.2298/JSC0506823A
dc.identifier.fulltexthttp://TechnoRep.tmf.bg.ac.rs/bitstream/id/2339/851.pdf
dc.identifier.rcubconv_2590
dc.identifier.scopus2-s2.0-31544450291
dc.identifier.wos000231057300005
dc.type.versionpublishedVersion


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