Phase-transfer catalyzed N-ethylation of N-ethyl-2-phenylacetamide
Апстракт
Phase-transfer catalyzed N-ethylations of N-ethyl-2-phenylacetamide (EPA) in the presence of powdered KOH (solid-liquid system) have been carried out in order to establish the effect of catalyst structure on the reaction. The formation of O- and C-products of alkylation is monitored. The effect of temperature on N-alkylation as well as on the rearrangement of O- to N-product of alkylation has been investigated. The influence of the structure of the quaternary ammonium cation (quat) and the anion type on the yield of the N-ethylation product is also discussed. A suitable mechanism for the phase-transfer catalysed reaction is suggested.
Извор:
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1996, 35, 11, 1201-1204Издавач:
- Natl Inst Science Communication, New Delhi
Институција/група
Tehnološko-metalurški fakultetTY - JOUR AU - Mijin, Dušan AU - Mišić-Vuković, Milica AU - Stojanović, Nadežda AU - Petrović, Slobodan PY - 1996 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/89 AB - Phase-transfer catalyzed N-ethylations of N-ethyl-2-phenylacetamide (EPA) in the presence of powdered KOH (solid-liquid system) have been carried out in order to establish the effect of catalyst structure on the reaction. The formation of O- and C-products of alkylation is monitored. The effect of temperature on N-alkylation as well as on the rearrangement of O- to N-product of alkylation has been investigated. The influence of the structure of the quaternary ammonium cation (quat) and the anion type on the yield of the N-ethylation product is also discussed. A suitable mechanism for the phase-transfer catalysed reaction is suggested. PB - Natl Inst Science Communication, New Delhi T2 - Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry T1 - Phase-transfer catalyzed N-ethylation of N-ethyl-2-phenylacetamide EP - 1204 IS - 11 SP - 1201 VL - 35 UR - https://hdl.handle.net/21.15107/rcub_technorep_89 ER -
@article{ author = "Mijin, Dušan and Mišić-Vuković, Milica and Stojanović, Nadežda and Petrović, Slobodan", year = "1996", abstract = "Phase-transfer catalyzed N-ethylations of N-ethyl-2-phenylacetamide (EPA) in the presence of powdered KOH (solid-liquid system) have been carried out in order to establish the effect of catalyst structure on the reaction. The formation of O- and C-products of alkylation is monitored. The effect of temperature on N-alkylation as well as on the rearrangement of O- to N-product of alkylation has been investigated. The influence of the structure of the quaternary ammonium cation (quat) and the anion type on the yield of the N-ethylation product is also discussed. A suitable mechanism for the phase-transfer catalysed reaction is suggested.", publisher = "Natl Inst Science Communication, New Delhi", journal = "Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry", title = "Phase-transfer catalyzed N-ethylation of N-ethyl-2-phenylacetamide", pages = "1204-1201", number = "11", volume = "35", url = "https://hdl.handle.net/21.15107/rcub_technorep_89" }
Mijin, D., Mišić-Vuković, M., Stojanović, N.,& Petrović, S.. (1996). Phase-transfer catalyzed N-ethylation of N-ethyl-2-phenylacetamide. in Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry Natl Inst Science Communication, New Delhi., 35(11), 1201-1204. https://hdl.handle.net/21.15107/rcub_technorep_89
Mijin D, Mišić-Vuković M, Stojanović N, Petrović S. Phase-transfer catalyzed N-ethylation of N-ethyl-2-phenylacetamide. in Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry. 1996;35(11):1201-1204. https://hdl.handle.net/21.15107/rcub_technorep_89 .
Mijin, Dušan, Mišić-Vuković, Milica, Stojanović, Nadežda, Petrović, Slobodan, "Phase-transfer catalyzed N-ethylation of N-ethyl-2-phenylacetamide" in Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 35, no. 11 (1996):1201-1204, https://hdl.handle.net/21.15107/rcub_technorep_89 .