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Citosenzor na bazi hromatofora - ispitivanje odgovora različitih biološki aktivnih agenasa

dc.creatorMojović, Ljiljana
dc.creatorDierksen, Karen
dc.creatorJovanović, Goran N.
dc.date.accessioned2021-03-10T10:33:39Z
dc.date.available2021-03-10T10:33:39Z
dc.date.issued2006
dc.identifier.issn1451-9372
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/941
dc.description.abstractThe design, operation and performances of a cytosensor based on immobilized living chromatophores isolated from Betta splendens Siamese fighting fish are presented in this paper. Development of the cell immobilization technique as an important cytosensor enabling technology, and integration of the immobilized cells in the cytosensor system is described. The cytosensor was used to test several classes of biologically active agents including neurotransmitters, adenyl cyclase activators, cytoskeleton effectors, cell membrane effectors, and protein synthesis inhibitors and the obtained responses were analyzed. Particular response features such as mode of response, its magnitude, kinetics, sensitivity and dose dependence were monitored and may be used as a basis for mathematical modeling of the responses. The results indicated that the cytosensor has great potential for use in food and water testing and in pharmacy.en
dc.description.abstractU radu je prikazan dizajn, način rada i karakteristike citosenzora na bazi imobilisanih hromatofora izolovanih iz vrste ribe Betta splendens, Sijamski borac. Ispitana je i razvijena tehnika imobilizacije ovih ćelija, koja predstavlja jednu od ključnih pomoćnih tehnologija na kojima se bazira funkcionisanje citosenzora, kao i uslovi potrebni da bi se imobilisane ćelije integrisale u mikroreaktor senzora. Ispitani su odgovori citosenzora na širok spektar biološki aktivnih agenasa koji uključuju: neurotransmitere aktivatore adenil ciklaze, agense koji deluju na ćelijski skeleton inhibitore sinteze proteina i agense koji deluju na ćelijsku membranu. Praćene su, analizirane i upoređene sledeće karakteristike odgovora hromatofora na ove agense: način odgovora, jačina odgovora, kinetika senzitivnost i zavisnost odgovora od koncentracije agensa. Na osnovu ovih karakteristika moguće je vršiti njihovo modelovanje i klasifikaciju. Rezultati su pokazali da je citosenzor pogodan za korišćenje u kontroli vode i hrane, zagađenja okoline, kao i u farmaceutske svrhe.sr
dc.publisherAssociation of the Chemical Engineers of Serbia
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceChemical Industry & Chemical Engineering Quarterly
dc.subjectfish chromatophoresen
dc.subjectcytosensoren
dc.subjectbiologically active agentsen
dc.subjecthromatofore ribasr
dc.subjectcitosenzorsr
dc.subjectbiološki aktivni agensisr
dc.titleChromatophore based cytosensor: Responses to various biologically active agentsen
dc.titleCitosenzor na bazi hromatofora - ispitivanje odgovora različitih biološki aktivnih agenasasr
dc.typearticle
dc.rights.licenseBY-NC-ND
dc.citation.epage70
dc.citation.issue1
dc.citation.other12(1): 63-70
dc.citation.spage63
dc.citation.volume12
dc.identifier.doi10.2298/CICEQ0601063M
dc.identifier.rcubconv_1633
dc.identifier.scopus2-s2.0-85034439996
dc.type.versionpublishedVersion


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