Show simple item record

dc.creatorMedović, Adela
dc.creatorŠkundrić, Petar
dc.creatorKostić, Mirjana
dc.creatorPajić-Lijaković, Ivana
dc.date.accessioned2021-03-10T10:35:44Z
dc.date.available2021-03-10T10:35:44Z
dc.date.issued2006
dc.identifier.issn1549-3296
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/973
dc.description.abstractThe aim of this study was to study insulin desorption from fibrous insulin artificial store in vitro as well as in vivo, with the intention to define a mathematical model that would describe this process. Release profile of cylindrical fibrous matrixes for various insulin concentrations, desorption temperatures, time periods, and pH were presented. Change of insulin concentration in the fibers and the effect of insulin release were discussed. This model was also used to predict the optimal conditions of the release process. Possibility of predicting the effect of the fibrous store design parameters (fibre radius, amount of bonded insulin, fiber type) on the resulting insulin release rate was the major advantage of this mathematical model. Also, taking all the relevant conditions regarding these experiments into consideration, by the application of mathematical model, the diffusion coefficient during insulin release was determined.en
dc.publisherWiley-Liss, Hoboken
dc.rightsrestrictedAccess
dc.sourceJournal of Biomedical Materials Research Part A
dc.subjectmathematical modelingen
dc.subjectdesorptionen
dc.subjectreleaseen
dc.subjectpolymeren
dc.subjectinsulinen
dc.subjectcation-exchange fibersen
dc.subjectin vitroen
dc.titleThe mathematical model of insulin desorption from the bioactive, fibrous artificial storeen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage642
dc.citation.issue3
dc.citation.other79A(3): 635-642
dc.citation.rankM21
dc.citation.spage635
dc.citation.volume79A
dc.identifier.doi10.1002/jbm.a.30838
dc.identifier.pmid16826597
dc.identifier.rcubconv_2751
dc.identifier.scopus2-s2.0-33751581061
dc.identifier.wos000242134700022
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record