An investigation of the synthesis of poly(L-lactide) as a biodegradable polymer for orthopaedic applications
Апстракт
The investigation is based upon recent research in the area of the synthesis of biodegradable poly(L-lactide) (PLLA) for biomedical applications using stannous octoate (SnOct) as an initiator. The objective was to investigate factors that affect the synthesis of poly(L-lactide), such as monomer purification, vacuum required for monomer drying, polymerization reacton time and catalyst concentration. Complete polymer characterization was done by 1H-NMR, IR spectroscopy and light scattering, in order to reveal the polymerization mechanism. An attempt was made to obtain a polymer of high molecular weight and good mechanical properties that could be used for the processing of biodegradable surgical sutures. Experiments showed that the optimum conditions to obtain polymer of high molecular weight (≈ 30 × 104) are: vacuum required for monomer drying (0.2 mmHg), purification of both monomer and polymer by recrystallization/precipitation, monomer/initiator mole ratio ([M]/[I] about 5000 and a p...olymerization time of approximately 50 h.
Кључне речи:
Biodegradable polymers / Medical applications / Poly-L-actide synthesisИзвор:
Journal of the Serbian Chemical Society, 1996, 61, 4-5, 311-318Издавач:
- Serbian Chemical Society, Belgrade
Институција/група
Tehnološko-metalurški fakultetTY - JOUR AU - Ristić, C. AU - Plavšić, Milenko B. AU - Goosen, M.F. AU - Sajc, L. AU - Antonović, Dušan AU - Bugarski, Branko PY - 1996 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/100 AB - The investigation is based upon recent research in the area of the synthesis of biodegradable poly(L-lactide) (PLLA) for biomedical applications using stannous octoate (SnOct) as an initiator. The objective was to investigate factors that affect the synthesis of poly(L-lactide), such as monomer purification, vacuum required for monomer drying, polymerization reacton time and catalyst concentration. Complete polymer characterization was done by 1H-NMR, IR spectroscopy and light scattering, in order to reveal the polymerization mechanism. An attempt was made to obtain a polymer of high molecular weight and good mechanical properties that could be used for the processing of biodegradable surgical sutures. Experiments showed that the optimum conditions to obtain polymer of high molecular weight (≈ 30 × 104) are: vacuum required for monomer drying (0.2 mmHg), purification of both monomer and polymer by recrystallization/precipitation, monomer/initiator mole ratio ([M]/[I] about 5000 and a polymerization time of approximately 50 h. PB - Serbian Chemical Society, Belgrade T2 - Journal of the Serbian Chemical Society T1 - An investigation of the synthesis of poly(L-lactide) as a biodegradable polymer for orthopaedic applications EP - 318 IS - 4-5 SP - 311 VL - 61 UR - https://hdl.handle.net/21.15107/rcub_technorep_100 ER -
@article{ author = "Ristić, C. and Plavšić, Milenko B. and Goosen, M.F. and Sajc, L. and Antonović, Dušan and Bugarski, Branko", year = "1996", abstract = "The investigation is based upon recent research in the area of the synthesis of biodegradable poly(L-lactide) (PLLA) for biomedical applications using stannous octoate (SnOct) as an initiator. The objective was to investigate factors that affect the synthesis of poly(L-lactide), such as monomer purification, vacuum required for monomer drying, polymerization reacton time and catalyst concentration. Complete polymer characterization was done by 1H-NMR, IR spectroscopy and light scattering, in order to reveal the polymerization mechanism. An attempt was made to obtain a polymer of high molecular weight and good mechanical properties that could be used for the processing of biodegradable surgical sutures. Experiments showed that the optimum conditions to obtain polymer of high molecular weight (≈ 30 × 104) are: vacuum required for monomer drying (0.2 mmHg), purification of both monomer and polymer by recrystallization/precipitation, monomer/initiator mole ratio ([M]/[I] about 5000 and a polymerization time of approximately 50 h.", publisher = "Serbian Chemical Society, Belgrade", journal = "Journal of the Serbian Chemical Society", title = "An investigation of the synthesis of poly(L-lactide) as a biodegradable polymer for orthopaedic applications", pages = "318-311", number = "4-5", volume = "61", url = "https://hdl.handle.net/21.15107/rcub_technorep_100" }
Ristić, C., Plavšić, M. B., Goosen, M.F., Sajc, L., Antonović, D.,& Bugarski, B.. (1996). An investigation of the synthesis of poly(L-lactide) as a biodegradable polymer for orthopaedic applications. in Journal of the Serbian Chemical Society Serbian Chemical Society, Belgrade., 61(4-5), 311-318. https://hdl.handle.net/21.15107/rcub_technorep_100
Ristić C, Plavšić MB, Goosen M, Sajc L, Antonović D, Bugarski B. An investigation of the synthesis of poly(L-lactide) as a biodegradable polymer for orthopaedic applications. in Journal of the Serbian Chemical Society. 1996;61(4-5):311-318. https://hdl.handle.net/21.15107/rcub_technorep_100 .
Ristić, C., Plavšić, Milenko B., Goosen, M.F., Sajc, L., Antonović, Dušan, Bugarski, Branko, "An investigation of the synthesis of poly(L-lactide) as a biodegradable polymer for orthopaedic applications" in Journal of the Serbian Chemical Society, 61, no. 4-5 (1996):311-318, https://hdl.handle.net/21.15107/rcub_technorep_100 .