Release and diffusion studies of hydrogels based on itaconic acid
Apstrakt
Controlled release studies of drugs (theophylline (TH), fenethylline hydrochloride (FE) and gentamicin sulphate (GS)) from pH sensitive poly(2-hydroxyethyl methacrylate/itaconic acid) (P(HEMA/IA)) hydrogels obtained by gamma irradiation were carried out to investigate transport phenomena. Drug behavior and release profiles were analyzed using the restriction coefficient combining the influence of network structure and the size of the drug on release and transport properties. The results demonstrated that the ratio of drug radius to polymer pore size and drugpolymer interactions were dominant factors in hindering the diffusion process. The diffusivity of a drug through the hydrogels decreases with the size of the drug molecules and with the decrease in gel pore size. The diffusion equations for used drugs explain drug transport in hydrogels.
Ključne reči:
2-hydroxyethyl methacrylate / controlled release systems / diffusion / drugs / hydrogel / itaconic acidIzvor:
Materials Science Forum, 2007, 555, 441-446Izdavač:
- 8th Conference of the Yugoslav Materials Research Society
Finansiranje / projekti:
- Regeneracija skeletnih tkiva pomognuta biomaterijalima kao tkivnim matricama - in vivo i in vitro studija (RS-MESTD-MPN2006-2010-145072)
- Modifikacija, sinteza i analiza nanostrukturnih materijala jonskim snopovima, gama zračenjem i vakuumskim deponovanjem (RS-MESTD-MPN2006-2010-141013)
DOI: 10.4028/0-87849-441-3.441
ISSN: 0255-5476
PubMed:
WoS: 000249653700071
Scopus: 2-s2.0-38348998798
Institucija/grupa
Tehnološko-metalurški fakultetTY - JOUR AU - Mićić, Maja M. AU - Tomić, Simonida AU - Filipović, Jovanka M. AU - Suljovrujić, Edin H. PY - 2007 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1019 AB - Controlled release studies of drugs (theophylline (TH), fenethylline hydrochloride (FE) and gentamicin sulphate (GS)) from pH sensitive poly(2-hydroxyethyl methacrylate/itaconic acid) (P(HEMA/IA)) hydrogels obtained by gamma irradiation were carried out to investigate transport phenomena. Drug behavior and release profiles were analyzed using the restriction coefficient combining the influence of network structure and the size of the drug on release and transport properties. The results demonstrated that the ratio of drug radius to polymer pore size and drugpolymer interactions were dominant factors in hindering the diffusion process. The diffusivity of a drug through the hydrogels decreases with the size of the drug molecules and with the decrease in gel pore size. The diffusion equations for used drugs explain drug transport in hydrogels. PB - 8th Conference of the Yugoslav Materials Research Society T2 - Materials Science Forum T1 - Release and diffusion studies of hydrogels based on itaconic acid EP - 446 SP - 441 VL - 555 DO - 10.4028/0-87849-441-3.441 ER -
@article{ author = "Mićić, Maja M. and Tomić, Simonida and Filipović, Jovanka M. and Suljovrujić, Edin H.", year = "2007", abstract = "Controlled release studies of drugs (theophylline (TH), fenethylline hydrochloride (FE) and gentamicin sulphate (GS)) from pH sensitive poly(2-hydroxyethyl methacrylate/itaconic acid) (P(HEMA/IA)) hydrogels obtained by gamma irradiation were carried out to investigate transport phenomena. Drug behavior and release profiles were analyzed using the restriction coefficient combining the influence of network structure and the size of the drug on release and transport properties. The results demonstrated that the ratio of drug radius to polymer pore size and drugpolymer interactions were dominant factors in hindering the diffusion process. The diffusivity of a drug through the hydrogels decreases with the size of the drug molecules and with the decrease in gel pore size. The diffusion equations for used drugs explain drug transport in hydrogels.", publisher = "8th Conference of the Yugoslav Materials Research Society", journal = "Materials Science Forum", title = "Release and diffusion studies of hydrogels based on itaconic acid", pages = "446-441", volume = "555", doi = "10.4028/0-87849-441-3.441" }
Mićić, M. M., Tomić, S., Filipović, J. M.,& Suljovrujić, E. H.. (2007). Release and diffusion studies of hydrogels based on itaconic acid. in Materials Science Forum 8th Conference of the Yugoslav Materials Research Society., 555, 441-446. https://doi.org/10.4028/0-87849-441-3.441
Mićić MM, Tomić S, Filipović JM, Suljovrujić EH. Release and diffusion studies of hydrogels based on itaconic acid. in Materials Science Forum. 2007;555:441-446. doi:10.4028/0-87849-441-3.441 .
Mićić, Maja M., Tomić, Simonida, Filipović, Jovanka M., Suljovrujić, Edin H., "Release and diffusion studies of hydrogels based on itaconic acid" in Materials Science Forum, 555 (2007):441-446, https://doi.org/10.4028/0-87849-441-3.441 . .