Solvent effects on the structure-activity relationship of pharmacological active 3-substituted-5,5-diphenylhydantoins
Samo za registrovane korisnike
2007
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Absorption spectra of eight 3-substituted-5,5-diphenylhydantoins have been recorded in fourteen solvents in the range 200-100 nm. The effect of solvent dipolarity/polarizability and solvent/solute hydrogen bonding interactions are analyzed by means of the linear solvation energy relationship (LSER) concept proposed by Kamlet and Taft. The lipophilic activity of the investigated hydantoins was estimated by the calculation of log(10) P values with the Advanced Chemistry Development Software. The calculated values of log(10) P were correlated with the ratio of the contributions of specific solvent interactions, and, by employing the linear dependence thus obtained, the pharmacological activity of the studied hydantoin derivatives is discussed.
Ključne reči:
hydantoins / absorption frequencies / solvent effect / Kamlet-Taft equation / pharmacological activity / lipophilicity parameter / specific solvent interactionsIzvor:
Journal of Solution Chemistry, 2007, 36, 7, 869-878Izdavač:
- Springer/Plenum Publishers, New York
DOI: 10.1007/s10953-007-9153-2
ISSN: 0095-9782
WoS: 000247033200004
Scopus: 2-s2.0-34249681314
Institucija/grupa
Tehnološko-metalurški fakultetTY - JOUR AU - Banjac, Nebojša AU - Ušćumlić, Gordana AU - Valentić, Nataša AU - Mijin, Dušan PY - 2007 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1098 AB - Absorption spectra of eight 3-substituted-5,5-diphenylhydantoins have been recorded in fourteen solvents in the range 200-100 nm. The effect of solvent dipolarity/polarizability and solvent/solute hydrogen bonding interactions are analyzed by means of the linear solvation energy relationship (LSER) concept proposed by Kamlet and Taft. The lipophilic activity of the investigated hydantoins was estimated by the calculation of log(10) P values with the Advanced Chemistry Development Software. The calculated values of log(10) P were correlated with the ratio of the contributions of specific solvent interactions, and, by employing the linear dependence thus obtained, the pharmacological activity of the studied hydantoin derivatives is discussed. PB - Springer/Plenum Publishers, New York T2 - Journal of Solution Chemistry T1 - Solvent effects on the structure-activity relationship of pharmacological active 3-substituted-5,5-diphenylhydantoins EP - 878 IS - 7 SP - 869 VL - 36 DO - 10.1007/s10953-007-9153-2 ER -
@article{ author = "Banjac, Nebojša and Ušćumlić, Gordana and Valentić, Nataša and Mijin, Dušan", year = "2007", abstract = "Absorption spectra of eight 3-substituted-5,5-diphenylhydantoins have been recorded in fourteen solvents in the range 200-100 nm. The effect of solvent dipolarity/polarizability and solvent/solute hydrogen bonding interactions are analyzed by means of the linear solvation energy relationship (LSER) concept proposed by Kamlet and Taft. The lipophilic activity of the investigated hydantoins was estimated by the calculation of log(10) P values with the Advanced Chemistry Development Software. The calculated values of log(10) P were correlated with the ratio of the contributions of specific solvent interactions, and, by employing the linear dependence thus obtained, the pharmacological activity of the studied hydantoin derivatives is discussed.", publisher = "Springer/Plenum Publishers, New York", journal = "Journal of Solution Chemistry", title = "Solvent effects on the structure-activity relationship of pharmacological active 3-substituted-5,5-diphenylhydantoins", pages = "878-869", number = "7", volume = "36", doi = "10.1007/s10953-007-9153-2" }
Banjac, N., Ušćumlić, G., Valentić, N.,& Mijin, D.. (2007). Solvent effects on the structure-activity relationship of pharmacological active 3-substituted-5,5-diphenylhydantoins. in Journal of Solution Chemistry Springer/Plenum Publishers, New York., 36(7), 869-878. https://doi.org/10.1007/s10953-007-9153-2
Banjac N, Ušćumlić G, Valentić N, Mijin D. Solvent effects on the structure-activity relationship of pharmacological active 3-substituted-5,5-diphenylhydantoins. in Journal of Solution Chemistry. 2007;36(7):869-878. doi:10.1007/s10953-007-9153-2 .
Banjac, Nebojša, Ušćumlić, Gordana, Valentić, Nataša, Mijin, Dušan, "Solvent effects on the structure-activity relationship of pharmacological active 3-substituted-5,5-diphenylhydantoins" in Journal of Solution Chemistry, 36, no. 7 (2007):869-878, https://doi.org/10.1007/s10953-007-9153-2 . .