Biomimetic Approaches to Design of Tissue Engineering Bioreactors
Apstrakt
Tissue engineering is an attractive strategy to address the increasing clinical need for tissue replacement. Engineered tissues can also serve as high-fidelity models for studies of development, disease and therapeutic modalities. Cultivation of three-dimensional tissue equivalents is necessarily based on the use of bioreactors, which are designed to provide controlled steady state cultivation conditions as well as required biochemical and physical regulatory signals. In this chapter, we review the design and operation of tissue engineering bioreactors, with the focus on biomimetic approaches to provide in vivo-like environments for rapid and orderly tissue development by cells cultured on a scaffold. Specifically, we focus on bioreactors for tissue engineering of two distinctly different tissues - articular cartilage and myocardium.
Ključne reči:
Tissue engineering / Cartilage / Myocardium / Bioreactor / Oxygen transport / Mechanical stimulationIzvor:
NATO Science for Peace and Security Series A: Chemistry and Biology, 2010, 115-129Finansiranje / projekti:
- Interakcija imobilisanih ćelija, tkiva i biološki aktivnih molekula u bioreaktorskim sistemima (RS-142075)
- Swiss National Science FoundationSwiss National Science Foundation (SNSF) [IB73B0-111016/1]
- NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [P41 EB002520-01, R01 DE016525, R01 HL076485-01]
- ARTEC
- NSERC DiscoveryNatural Sciences and Engineering Research Council of Canada
DOI: 10.1007/978-90-481-8790-4-7
ISSN: 1874-6489
PubMed:
WoS: 000285737600007
Scopus: 2-s2.0-77956415768
Institucija/grupa
Tehnološko-metalurški fakultetTY - JOUR AU - Obradović, Bojana AU - Radisić, Milica AU - Vunjak-Novaković, Gordana PY - 2010 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1542 AB - Tissue engineering is an attractive strategy to address the increasing clinical need for tissue replacement. Engineered tissues can also serve as high-fidelity models for studies of development, disease and therapeutic modalities. Cultivation of three-dimensional tissue equivalents is necessarily based on the use of bioreactors, which are designed to provide controlled steady state cultivation conditions as well as required biochemical and physical regulatory signals. In this chapter, we review the design and operation of tissue engineering bioreactors, with the focus on biomimetic approaches to provide in vivo-like environments for rapid and orderly tissue development by cells cultured on a scaffold. Specifically, we focus on bioreactors for tissue engineering of two distinctly different tissues - articular cartilage and myocardium. T2 - NATO Science for Peace and Security Series A: Chemistry and Biology T1 - Biomimetic Approaches to Design of Tissue Engineering Bioreactors EP - 129 SP - 115 DO - 10.1007/978-90-481-8790-4-7 ER -
@article{ author = "Obradović, Bojana and Radisić, Milica and Vunjak-Novaković, Gordana", year = "2010", abstract = "Tissue engineering is an attractive strategy to address the increasing clinical need for tissue replacement. Engineered tissues can also serve as high-fidelity models for studies of development, disease and therapeutic modalities. Cultivation of three-dimensional tissue equivalents is necessarily based on the use of bioreactors, which are designed to provide controlled steady state cultivation conditions as well as required biochemical and physical regulatory signals. In this chapter, we review the design and operation of tissue engineering bioreactors, with the focus on biomimetic approaches to provide in vivo-like environments for rapid and orderly tissue development by cells cultured on a scaffold. Specifically, we focus on bioreactors for tissue engineering of two distinctly different tissues - articular cartilage and myocardium.", journal = "NATO Science for Peace and Security Series A: Chemistry and Biology", title = "Biomimetic Approaches to Design of Tissue Engineering Bioreactors", pages = "129-115", doi = "10.1007/978-90-481-8790-4-7" }
Obradović, B., Radisić, M.,& Vunjak-Novaković, G.. (2010). Biomimetic Approaches to Design of Tissue Engineering Bioreactors. in NATO Science for Peace and Security Series A: Chemistry and Biology, 115-129. https://doi.org/10.1007/978-90-481-8790-4-7
Obradović B, Radisić M, Vunjak-Novaković G. Biomimetic Approaches to Design of Tissue Engineering Bioreactors. in NATO Science for Peace and Security Series A: Chemistry and Biology. 2010;:115-129. doi:10.1007/978-90-481-8790-4-7 .
Obradović, Bojana, Radisić, Milica, Vunjak-Novaković, Gordana, "Biomimetic Approaches to Design of Tissue Engineering Bioreactors" in NATO Science for Peace and Security Series A: Chemistry and Biology (2010):115-129, https://doi.org/10.1007/978-90-481-8790-4-7 . .