Poly[(N-isopropylacrylamide)-co-(itaconic acid)] hydrogels with poly(ethylene glycol)
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2010
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The aim of the work reported here was to investigate temperature- and pH-sensitive hydrogels of N-isopropylacrylamide (NIPAM) and itaconic acid (IA) and their semi-interpenetrating polymer networks (semi-IPNs) with varying contents of poly(ethylene glycol) (PEG). The stimuli responsiveness, swelling behaviour and mechanical properties of the hydrogels and semi-IPNs were studied in order to investigate the effect of various amounts of PEG. Pulsed-gradient spin-echo NMR experiments were carried out to investigate the diffusion process. The pH sensitivity increased with an increasing amount of PEG in the semi-IPNs, while the overall rate of water uptake was diffusion-controlled (n lt 0.5). For certain PEG contents (5 and 10 wt%), the semi-IPNs exhibited better mechanical properties than the poly(NIPAM-co-IA) copolymer. The calculated values of the self-diffusion coefficients of water indicated facilitated diffusion of water through the system with increased amounts of PEG, while the sel...f-diffusion coefficients of a model compound, metoprolol tartrate, showed no significant dependence on the amount of PEG. According to the results obtained and compared to results reported in the literature, the investigated semi-IPNs may have potential applications in the controlled release of macromolecular active agents such as proteins and peptides.
Ključne reči:
hydrogels / semi-IPNs / mechanical properties / diffusionIzvor:
Polymer International, 2010, 59, 2, 256-262Izdavač:
- Wiley, Hoboken
Finansiranje / projekti:
- Sinteza i karakterizacija polimera i polimernih (nano)kompozita definisane molekulske i nadmolekulske strukture (RS-MESTD-MPN2006-2010-142023)
DOI: 10.1002/pi.2717
ISSN: 0959-8103
WoS: 000273922300017
Scopus: 2-s2.0-77953343291
Institucija/grupa
Tehnološko-metalurški fakultetTY - JOUR AU - Kalagasidis Krušić, Melina AU - Veličković, Sava AU - Griffiths, Peter C. AU - Filipović, Jovanka PY - 2010 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1682 AB - The aim of the work reported here was to investigate temperature- and pH-sensitive hydrogels of N-isopropylacrylamide (NIPAM) and itaconic acid (IA) and their semi-interpenetrating polymer networks (semi-IPNs) with varying contents of poly(ethylene glycol) (PEG). The stimuli responsiveness, swelling behaviour and mechanical properties of the hydrogels and semi-IPNs were studied in order to investigate the effect of various amounts of PEG. Pulsed-gradient spin-echo NMR experiments were carried out to investigate the diffusion process. The pH sensitivity increased with an increasing amount of PEG in the semi-IPNs, while the overall rate of water uptake was diffusion-controlled (n lt 0.5). For certain PEG contents (5 and 10 wt%), the semi-IPNs exhibited better mechanical properties than the poly(NIPAM-co-IA) copolymer. The calculated values of the self-diffusion coefficients of water indicated facilitated diffusion of water through the system with increased amounts of PEG, while the self-diffusion coefficients of a model compound, metoprolol tartrate, showed no significant dependence on the amount of PEG. According to the results obtained and compared to results reported in the literature, the investigated semi-IPNs may have potential applications in the controlled release of macromolecular active agents such as proteins and peptides. PB - Wiley, Hoboken T2 - Polymer International T1 - Poly[(N-isopropylacrylamide)-co-(itaconic acid)] hydrogels with poly(ethylene glycol) EP - 262 IS - 2 SP - 256 VL - 59 DO - 10.1002/pi.2717 ER -
@article{ author = "Kalagasidis Krušić, Melina and Veličković, Sava and Griffiths, Peter C. and Filipović, Jovanka", year = "2010", abstract = "The aim of the work reported here was to investigate temperature- and pH-sensitive hydrogels of N-isopropylacrylamide (NIPAM) and itaconic acid (IA) and their semi-interpenetrating polymer networks (semi-IPNs) with varying contents of poly(ethylene glycol) (PEG). The stimuli responsiveness, swelling behaviour and mechanical properties of the hydrogels and semi-IPNs were studied in order to investigate the effect of various amounts of PEG. Pulsed-gradient spin-echo NMR experiments were carried out to investigate the diffusion process. The pH sensitivity increased with an increasing amount of PEG in the semi-IPNs, while the overall rate of water uptake was diffusion-controlled (n lt 0.5). For certain PEG contents (5 and 10 wt%), the semi-IPNs exhibited better mechanical properties than the poly(NIPAM-co-IA) copolymer. The calculated values of the self-diffusion coefficients of water indicated facilitated diffusion of water through the system with increased amounts of PEG, while the self-diffusion coefficients of a model compound, metoprolol tartrate, showed no significant dependence on the amount of PEG. According to the results obtained and compared to results reported in the literature, the investigated semi-IPNs may have potential applications in the controlled release of macromolecular active agents such as proteins and peptides.", publisher = "Wiley, Hoboken", journal = "Polymer International", title = "Poly[(N-isopropylacrylamide)-co-(itaconic acid)] hydrogels with poly(ethylene glycol)", pages = "262-256", number = "2", volume = "59", doi = "10.1002/pi.2717" }
Kalagasidis Krušić, M., Veličković, S., Griffiths, P. C.,& Filipović, J.. (2010). Poly[(N-isopropylacrylamide)-co-(itaconic acid)] hydrogels with poly(ethylene glycol). in Polymer International Wiley, Hoboken., 59(2), 256-262. https://doi.org/10.1002/pi.2717
Kalagasidis Krušić M, Veličković S, Griffiths PC, Filipović J. Poly[(N-isopropylacrylamide)-co-(itaconic acid)] hydrogels with poly(ethylene glycol). in Polymer International. 2010;59(2):256-262. doi:10.1002/pi.2717 .
Kalagasidis Krušić, Melina, Veličković, Sava, Griffiths, Peter C., Filipović, Jovanka, "Poly[(N-isopropylacrylamide)-co-(itaconic acid)] hydrogels with poly(ethylene glycol)" in Polymer International, 59, no. 2 (2010):256-262, https://doi.org/10.1002/pi.2717 . .