Structure optimization of polylactide microcapsules for controlled drug release
Само за регистроване кориснике
1998
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The influence of starting material properties on physical characteristics and drug release kinetics of poly-L-lactide microcapsules was investigated. The density, the distribution of the diameter size of microcapsules, the voidage and the active substance (methylene blue and Sudan III tracers) released concentrations, in paralel with microcapsules structure were studied. It was found that the density, size and structure of the microcapsules influenced in the polymer molar weight. In the case of the voidage, it exist the influence of the tracer and the polymer molar weight. The kinetic studies showed that the release patterns were similar and controllable. It was concluded that PLLA microcapsules showed a great potential for utilization in the active substance administration.
Кључне речи:
controlled drug release / microcapsules / polylactide / tracer / Sudan III / polymer kinetics / polymer characterizationИзвор:
Advanced Materials and Processes: Yucomat II, 1998, 282-2, 271-280Издавач:
- Trans Tech Publications Ltd, Durnten-Zurich
DOI: 10.4028/www.scientific.net/MSF.282-283.271
ISSN: 0255-5476
WoS: 000075079900038
Scopus: 2-s2.0-0031625348
Институција/група
Tehnološko-metalurški fakultetTY - JOUR AU - Plavšić, Milenko B. AU - Tomić, S AU - Sajc, L. AU - Bugarski, Branko AU - Jovanović, G PY - 1998 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/180 AB - The influence of starting material properties on physical characteristics and drug release kinetics of poly-L-lactide microcapsules was investigated. The density, the distribution of the diameter size of microcapsules, the voidage and the active substance (methylene blue and Sudan III tracers) released concentrations, in paralel with microcapsules structure were studied. It was found that the density, size and structure of the microcapsules influenced in the polymer molar weight. In the case of the voidage, it exist the influence of the tracer and the polymer molar weight. The kinetic studies showed that the release patterns were similar and controllable. It was concluded that PLLA microcapsules showed a great potential for utilization in the active substance administration. PB - Trans Tech Publications Ltd, Durnten-Zurich T2 - Advanced Materials and Processes: Yucomat II T1 - Structure optimization of polylactide microcapsules for controlled drug release EP - 280 SP - 271 VL - 282-2 DO - 10.4028/www.scientific.net/MSF.282-283.271 ER -
@article{ author = "Plavšić, Milenko B. and Tomić, S and Sajc, L. and Bugarski, Branko and Jovanović, G", year = "1998", abstract = "The influence of starting material properties on physical characteristics and drug release kinetics of poly-L-lactide microcapsules was investigated. The density, the distribution of the diameter size of microcapsules, the voidage and the active substance (methylene blue and Sudan III tracers) released concentrations, in paralel with microcapsules structure were studied. It was found that the density, size and structure of the microcapsules influenced in the polymer molar weight. In the case of the voidage, it exist the influence of the tracer and the polymer molar weight. The kinetic studies showed that the release patterns were similar and controllable. It was concluded that PLLA microcapsules showed a great potential for utilization in the active substance administration.", publisher = "Trans Tech Publications Ltd, Durnten-Zurich", journal = "Advanced Materials and Processes: Yucomat II", title = "Structure optimization of polylactide microcapsules for controlled drug release", pages = "280-271", volume = "282-2", doi = "10.4028/www.scientific.net/MSF.282-283.271" }
Plavšić, M. B., Tomić, S., Sajc, L., Bugarski, B.,& Jovanović, G.. (1998). Structure optimization of polylactide microcapsules for controlled drug release. in Advanced Materials and Processes: Yucomat II Trans Tech Publications Ltd, Durnten-Zurich., 282-2, 271-280. https://doi.org/10.4028/www.scientific.net/MSF.282-283.271
Plavšić MB, Tomić S, Sajc L, Bugarski B, Jovanović G. Structure optimization of polylactide microcapsules for controlled drug release. in Advanced Materials and Processes: Yucomat II. 1998;282-2:271-280. doi:10.4028/www.scientific.net/MSF.282-283.271 .
Plavšić, Milenko B., Tomić, S, Sajc, L., Bugarski, Branko, Jovanović, G, "Structure optimization of polylactide microcapsules for controlled drug release" in Advanced Materials and Processes: Yucomat II, 282-2 (1998):271-280, https://doi.org/10.4028/www.scientific.net/MSF.282-283.271 . .