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The influence of silicon substitution on the properties of spherical- and whisker-like biphasic alpha-calcium-phosphate/hydroxyapatite particles
dc.creator | Jokić, Bojan | |
dc.creator | Mitrić, Miodrag | |
dc.creator | Popović, Maja | |
dc.creator | Sima, L. | |
dc.creator | Petrescu, S. M. | |
dc.creator | Petrović, Rada | |
dc.creator | Janaćković, Đorđe | |
dc.date.accessioned | 2021-03-10T11:33:33Z | |
dc.date.available | 2021-03-10T11:33:33Z | |
dc.date.issued | 2011 | |
dc.identifier.issn | 0957-4530 | |
dc.identifier.uri | http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1863 | |
dc.description.abstract | In this work, the influence of the morphology of hydroxyapatite particles on silicon substitution through hydrothermal synthesis performed under the same conditions was investigated. Spherical- and whisker-like hydroxyapatite particles were obtained starting from calcium-nitrate, sodium dihydrogen phosphate, disodium-ethylenediaminetetraacetic acid and urea (used only for the synthesis of whisker-like particles) dissolved in aqueous solutions. Silicon was introduced into the solution using tetraethylorthosilicate. X-ray diffraction, infrared spectroscopy, scanning electron microscopy, energy-dispersive X-ray spectroscopy and transmission electron microscopy indicate that silicon doping induce different phase compositions and bioactivity of spherical- and whisker-like hydroxyapatite particles obtained under the same hydrothermal conditions. Silicon-substituted, spherical hydroxyapatites particles showed greater phase transformation to silicon-substituted alpha- calcium-phosphate compared with whiskers-like hydroxyapatite particles synthesized with the same amount of added silicon. Metabolic activity assay performed with SaOs2 osteosarcoma cells showed better biocompatibility of annealed biphasic spherical-like particles compared with annealed whiskerlike particles while dried spherical-like particles induce high cytotoxicity effect. | en |
dc.publisher | Springer, Dordrecht | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45019/RS// | |
dc.rights | restrictedAccess | |
dc.source | Journal of Materials Science-Materials in Medicine | |
dc.title | The influence of silicon substitution on the properties of spherical- and whisker-like biphasic alpha-calcium-phosphate/hydroxyapatite particles | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 2185 | |
dc.citation.issue | 10 | |
dc.citation.other | 22(10): 2175-2185 | |
dc.citation.rank | M21 | |
dc.citation.spage | 2175 | |
dc.citation.volume | 22 | |
dc.identifier.doi | 10.1007/s10856-011-4412-6 | |
dc.identifier.pmid | 21823030 | |
dc.identifier.scopus | 2-s2.0-84855166904 | |
dc.identifier.wos | 000295712600004 | |
dc.type.version | publishedVersion |