Synthesis, characterization and drug release properties of thermosensitive poly(N-isopropylacrylamide) microgels
Samo za registrovane korisnike
2012
Autori
Petrusić, StojankaJovančić, Petar
Lewandowski, Maryline
Giraud, Stephane
Bugarski, Branko
Đonlagić, Jasna
Koncar, Vladan
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
This study was aimed at optimizing the structure and properties of poly(N-isopropylacrylamide) (PNIPAAm) microgels prepared by inverse suspension polymerization. The influence of the oil-to-water phase ratio, the concentration of emulsifier, and the monomer-to-crosslinker molar ratio on selected properties of the PNIPAAm microgels was examined. Regularity of the microgels shape was estimated by optical microscopy. Laser diffraction technique was used to determine the microgels mean size and size distribution. Equilibrium swelling ratio was studied gravimetrically. Morphology of microgels was followed by SEM. Volume phase transition temperature of PNIPAAm microgels was determined by differential scanning calorimetry. The results obtained imply that the mean diameter of microgels and their equilibrium swelling ratio highly depend on the concentration of emulsifier in oil phase and the crosslinking degree of PNIPAAm. The crosslinking degree of PNIPAAm has no substantial effect on the volu...me phase transition temperature that is demonstrated to be around 33 degrees C even after complete heating-cooling-heating cycle. In addition, it was confirmed that the swollen microgels have a porous, honeycomb-like structure. Release profiles of procaine hydrochloride from the PNIPAAm microgels confirmed their potential to be considered as efficient matrices in drug release applications.
Ključne reči:
Poly(N-isopropylacrylamide) / Thermosensitive microgels / Inverse suspension polymerization / Volume phase transition / Controlled drug releaseIzvor:
Journal of Polymer Research, 2012, 19, 10Izdavač:
- Springer, Dordrecht
Finansiranje / projekti:
- ARCUS - Nord-Pas-de-Calais/Bulgarie - Roumanie - SerbieRegion Hauts-de-France
- French Ministry of Foreign Affairs
- Region Nord-Pas-De-CalaisRegion Hauts-de-France
- Razvoj novih inkapsulacionih i enzimskih tehnologija za proizvodnju biokatalizatora i biološki aktivnih komponenata hrane u cilju povećanja njene konkurentnosti, kvaliteta i bezbednosti (RS-46010)
DOI: 10.1007/s10965-012-9979-1
ISSN: 1022-9760
WoS: 000309339000009
Scopus: 2-s2.0-84866073914
Institucija/grupa
Tehnološko-metalurški fakultetTY - JOUR AU - Petrusić, Stojanka AU - Jovančić, Petar AU - Lewandowski, Maryline AU - Giraud, Stephane AU - Bugarski, Branko AU - Đonlagić, Jasna AU - Koncar, Vladan PY - 2012 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2178 AB - This study was aimed at optimizing the structure and properties of poly(N-isopropylacrylamide) (PNIPAAm) microgels prepared by inverse suspension polymerization. The influence of the oil-to-water phase ratio, the concentration of emulsifier, and the monomer-to-crosslinker molar ratio on selected properties of the PNIPAAm microgels was examined. Regularity of the microgels shape was estimated by optical microscopy. Laser diffraction technique was used to determine the microgels mean size and size distribution. Equilibrium swelling ratio was studied gravimetrically. Morphology of microgels was followed by SEM. Volume phase transition temperature of PNIPAAm microgels was determined by differential scanning calorimetry. The results obtained imply that the mean diameter of microgels and their equilibrium swelling ratio highly depend on the concentration of emulsifier in oil phase and the crosslinking degree of PNIPAAm. The crosslinking degree of PNIPAAm has no substantial effect on the volume phase transition temperature that is demonstrated to be around 33 degrees C even after complete heating-cooling-heating cycle. In addition, it was confirmed that the swollen microgels have a porous, honeycomb-like structure. Release profiles of procaine hydrochloride from the PNIPAAm microgels confirmed their potential to be considered as efficient matrices in drug release applications. PB - Springer, Dordrecht T2 - Journal of Polymer Research T1 - Synthesis, characterization and drug release properties of thermosensitive poly(N-isopropylacrylamide) microgels IS - 10 VL - 19 DO - 10.1007/s10965-012-9979-1 ER -
@article{ author = "Petrusić, Stojanka and Jovančić, Petar and Lewandowski, Maryline and Giraud, Stephane and Bugarski, Branko and Đonlagić, Jasna and Koncar, Vladan", year = "2012", abstract = "This study was aimed at optimizing the structure and properties of poly(N-isopropylacrylamide) (PNIPAAm) microgels prepared by inverse suspension polymerization. The influence of the oil-to-water phase ratio, the concentration of emulsifier, and the monomer-to-crosslinker molar ratio on selected properties of the PNIPAAm microgels was examined. Regularity of the microgels shape was estimated by optical microscopy. Laser diffraction technique was used to determine the microgels mean size and size distribution. Equilibrium swelling ratio was studied gravimetrically. Morphology of microgels was followed by SEM. Volume phase transition temperature of PNIPAAm microgels was determined by differential scanning calorimetry. The results obtained imply that the mean diameter of microgels and their equilibrium swelling ratio highly depend on the concentration of emulsifier in oil phase and the crosslinking degree of PNIPAAm. The crosslinking degree of PNIPAAm has no substantial effect on the volume phase transition temperature that is demonstrated to be around 33 degrees C even after complete heating-cooling-heating cycle. In addition, it was confirmed that the swollen microgels have a porous, honeycomb-like structure. Release profiles of procaine hydrochloride from the PNIPAAm microgels confirmed their potential to be considered as efficient matrices in drug release applications.", publisher = "Springer, Dordrecht", journal = "Journal of Polymer Research", title = "Synthesis, characterization and drug release properties of thermosensitive poly(N-isopropylacrylamide) microgels", number = "10", volume = "19", doi = "10.1007/s10965-012-9979-1" }
Petrusić, S., Jovančić, P., Lewandowski, M., Giraud, S., Bugarski, B., Đonlagić, J.,& Koncar, V.. (2012). Synthesis, characterization and drug release properties of thermosensitive poly(N-isopropylacrylamide) microgels. in Journal of Polymer Research Springer, Dordrecht., 19(10). https://doi.org/10.1007/s10965-012-9979-1
Petrusić S, Jovančić P, Lewandowski M, Giraud S, Bugarski B, Đonlagić J, Koncar V. Synthesis, characterization and drug release properties of thermosensitive poly(N-isopropylacrylamide) microgels. in Journal of Polymer Research. 2012;19(10). doi:10.1007/s10965-012-9979-1 .
Petrusić, Stojanka, Jovančić, Petar, Lewandowski, Maryline, Giraud, Stephane, Bugarski, Branko, Đonlagić, Jasna, Koncar, Vladan, "Synthesis, characterization and drug release properties of thermosensitive poly(N-isopropylacrylamide) microgels" in Journal of Polymer Research, 19, no. 10 (2012), https://doi.org/10.1007/s10965-012-9979-1 . .