Characterization and behavior of anesthetic bioactive textile complex in vitro condition
Authorized Users Only
2012
Authors
Simović, LjiljanaŠkundrić, Petar
Medović-Baralić, Adela
Pajić-Lijaković, Ivana
Milutinović-Nikolić, Aleksandra
Article (Published version)
Metadata
Show full item recordAbstract
In this study, a bioactive complex containing nonwoven textile material (polypropilene (PP)/viscose), chitosan hydrogel, and lidocaine hydrochloride, was designed. The purpose of such biomedical textile was in the treatment of painful sites. Mercury intrusion porosimetry was used in order to estimate the influence of medical impregnation on porous structure of nonwoven material. It was estimated that more than 97% of pores in untreated nonwoven sample were larger than 15 mu m. Anesthetic treatment of nonwoven reduced total pore volume of ultramacropores and macropores, while total pore volume of mesopores slightly increased. Lidocaine hydrochloride release from the anesthetic/chitosan hydrogel/nonwoven complex was measured in vitro by Franz diffusion cell technique. Mathematical model was developed to estimate the release of the lidocaine from obtained bioactive textile material. The diffusive transport of lidocaine hydrochloride through three connected layers, i.e., polymer hydrogel, ...membrane, and solution is modeled based on Fick's second law. Taking all the relevant conditions, regarding this experiment, into consideration, the coefficient of lidocaine diffusion through the polymer hydrogel, as well as the concentration ratio parameter were determined by the mathematical model.
Keywords:
mathematical model / lidocaine / nonwoven / chitosan / controlled releaseSource:
Journal of Biomedical Materials Research Part A, 2012, 100A, 1, 1-6Publisher:
- Wiley-Blackwell, Malden
Funding / projects:
- Medieval Serbian lands (XIII-XV century): political, economic, social and legal processes (RS-177029)
DOI: 10.1002/jbm.a.33234
ISSN: 1549-3296
PubMed: 21954107
WoS: 000297740800001
Scopus: 2-s2.0-81855182166
Institution/Community
Tehnološko-metalurški fakultetTY - JOUR AU - Simović, Ljiljana AU - Škundrić, Petar AU - Medović-Baralić, Adela AU - Pajić-Lijaković, Ivana AU - Milutinović-Nikolić, Aleksandra PY - 2012 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2238 AB - In this study, a bioactive complex containing nonwoven textile material (polypropilene (PP)/viscose), chitosan hydrogel, and lidocaine hydrochloride, was designed. The purpose of such biomedical textile was in the treatment of painful sites. Mercury intrusion porosimetry was used in order to estimate the influence of medical impregnation on porous structure of nonwoven material. It was estimated that more than 97% of pores in untreated nonwoven sample were larger than 15 mu m. Anesthetic treatment of nonwoven reduced total pore volume of ultramacropores and macropores, while total pore volume of mesopores slightly increased. Lidocaine hydrochloride release from the anesthetic/chitosan hydrogel/nonwoven complex was measured in vitro by Franz diffusion cell technique. Mathematical model was developed to estimate the release of the lidocaine from obtained bioactive textile material. The diffusive transport of lidocaine hydrochloride through three connected layers, i.e., polymer hydrogel, membrane, and solution is modeled based on Fick's second law. Taking all the relevant conditions, regarding this experiment, into consideration, the coefficient of lidocaine diffusion through the polymer hydrogel, as well as the concentration ratio parameter were determined by the mathematical model. PB - Wiley-Blackwell, Malden T2 - Journal of Biomedical Materials Research Part A T1 - Characterization and behavior of anesthetic bioactive textile complex in vitro condition EP - 6 IS - 1 SP - 1 VL - 100A DO - 10.1002/jbm.a.33234 ER -
@article{ author = "Simović, Ljiljana and Škundrić, Petar and Medović-Baralić, Adela and Pajić-Lijaković, Ivana and Milutinović-Nikolić, Aleksandra", year = "2012", abstract = "In this study, a bioactive complex containing nonwoven textile material (polypropilene (PP)/viscose), chitosan hydrogel, and lidocaine hydrochloride, was designed. The purpose of such biomedical textile was in the treatment of painful sites. Mercury intrusion porosimetry was used in order to estimate the influence of medical impregnation on porous structure of nonwoven material. It was estimated that more than 97% of pores in untreated nonwoven sample were larger than 15 mu m. Anesthetic treatment of nonwoven reduced total pore volume of ultramacropores and macropores, while total pore volume of mesopores slightly increased. Lidocaine hydrochloride release from the anesthetic/chitosan hydrogel/nonwoven complex was measured in vitro by Franz diffusion cell technique. Mathematical model was developed to estimate the release of the lidocaine from obtained bioactive textile material. The diffusive transport of lidocaine hydrochloride through three connected layers, i.e., polymer hydrogel, membrane, and solution is modeled based on Fick's second law. Taking all the relevant conditions, regarding this experiment, into consideration, the coefficient of lidocaine diffusion through the polymer hydrogel, as well as the concentration ratio parameter were determined by the mathematical model.", publisher = "Wiley-Blackwell, Malden", journal = "Journal of Biomedical Materials Research Part A", title = "Characterization and behavior of anesthetic bioactive textile complex in vitro condition", pages = "6-1", number = "1", volume = "100A", doi = "10.1002/jbm.a.33234" }
Simović, L., Škundrić, P., Medović-Baralić, A., Pajić-Lijaković, I.,& Milutinović-Nikolić, A.. (2012). Characterization and behavior of anesthetic bioactive textile complex in vitro condition. in Journal of Biomedical Materials Research Part A Wiley-Blackwell, Malden., 100A(1), 1-6. https://doi.org/10.1002/jbm.a.33234
Simović L, Škundrić P, Medović-Baralić A, Pajić-Lijaković I, Milutinović-Nikolić A. Characterization and behavior of anesthetic bioactive textile complex in vitro condition. in Journal of Biomedical Materials Research Part A. 2012;100A(1):1-6. doi:10.1002/jbm.a.33234 .
Simović, Ljiljana, Škundrić, Petar, Medović-Baralić, Adela, Pajić-Lijaković, Ivana, Milutinović-Nikolić, Aleksandra, "Characterization and behavior of anesthetic bioactive textile complex in vitro condition" in Journal of Biomedical Materials Research Part A, 100A, no. 1 (2012):1-6, https://doi.org/10.1002/jbm.a.33234 . .