Hemocompatibility, swelling and thermal properties of hydrogels based on 2-hydroxyethyl acrylate, itaconic acid and poly(ethylene glycol) dimethacrylate
Abstract
Two series of novel hydrogels, based on 2-hydroxyethyl acrylate (HEA), itaconic acid (IA), and two poly(ethylene glycol) dimethacrylates (PEGDMA), of different ethylene glycol chain lengths, were prepared by free radical crosslinking copolymerization. The influence of different ethylene glycol chain lengths and concentration in P(HEA/IA/PEGDMA) hydrogels on biocompatibility, swelling and thermal properties was investigated. All samples in contact with blood showed a mean hemolysis value lt 1.0 % in the direct contact assay, and even lt 0.5 % in the indirect contact assay, for in vitro testing conditions. Swelling studies, conducted in a physiological pH and temperature range, showed pH sensitivity and relatively small changes of equilibrium swelling with temperature, which varied with PEGDMA molecular weight. The glass transition temperatures (T (g)) of P(HEA/IA/PEGDMA) networks were in the range 28.1-36.9 A degrees C, respectively, and also dependent on copolymer composition. Due ...to good biocompatibility, favorable swelling, and thermal properties these hydrogels show good potential for biomedical uses.
Keywords:
Hydrogel / 2-Hydroxyethyl acrylate / Itaconic acid / Poly(ethylene glycol) dimethacrylate / Hemocompatibility / pH-sensitive and temperature-dependent swelling / Network parameters / Thermal properties / Glass transition temperatureSource:
Polymer Bulletin, 2013, 70, 10, 2895-2909Publisher:
- Springer, New York
Funding / projects:
- Chemical and structural designing of nanomaterials for application in medicine and tissue engineering (RS-MESTD-Basic Research (BR or ON)-172026)
- Synthesis and characterization of novel functional polymers and polymeric nanocomposites (RS-MESTD-Basic Research (BR or ON)-172062)
DOI: 10.1007/s00289-013-0995-z
ISSN: 0170-0839
WoS: 000323668200017
Scopus: 2-s2.0-84883456781
Institution/Community
Tehnološko-metalurški fakultetTY - JOUR AU - Tomić, Simonida AU - Jovašević, Jovana S. AU - Filipović, Jovanka M. PY - 2013 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2399 AB - Two series of novel hydrogels, based on 2-hydroxyethyl acrylate (HEA), itaconic acid (IA), and two poly(ethylene glycol) dimethacrylates (PEGDMA), of different ethylene glycol chain lengths, were prepared by free radical crosslinking copolymerization. The influence of different ethylene glycol chain lengths and concentration in P(HEA/IA/PEGDMA) hydrogels on biocompatibility, swelling and thermal properties was investigated. All samples in contact with blood showed a mean hemolysis value lt 1.0 % in the direct contact assay, and even lt 0.5 % in the indirect contact assay, for in vitro testing conditions. Swelling studies, conducted in a physiological pH and temperature range, showed pH sensitivity and relatively small changes of equilibrium swelling with temperature, which varied with PEGDMA molecular weight. The glass transition temperatures (T (g)) of P(HEA/IA/PEGDMA) networks were in the range 28.1-36.9 A degrees C, respectively, and also dependent on copolymer composition. Due to good biocompatibility, favorable swelling, and thermal properties these hydrogels show good potential for biomedical uses. PB - Springer, New York T2 - Polymer Bulletin T1 - Hemocompatibility, swelling and thermal properties of hydrogels based on 2-hydroxyethyl acrylate, itaconic acid and poly(ethylene glycol) dimethacrylate EP - 2909 IS - 10 SP - 2895 VL - 70 DO - 10.1007/s00289-013-0995-z ER -
@article{ author = "Tomić, Simonida and Jovašević, Jovana S. and Filipović, Jovanka M.", year = "2013", abstract = "Two series of novel hydrogels, based on 2-hydroxyethyl acrylate (HEA), itaconic acid (IA), and two poly(ethylene glycol) dimethacrylates (PEGDMA), of different ethylene glycol chain lengths, were prepared by free radical crosslinking copolymerization. The influence of different ethylene glycol chain lengths and concentration in P(HEA/IA/PEGDMA) hydrogels on biocompatibility, swelling and thermal properties was investigated. All samples in contact with blood showed a mean hemolysis value lt 1.0 % in the direct contact assay, and even lt 0.5 % in the indirect contact assay, for in vitro testing conditions. Swelling studies, conducted in a physiological pH and temperature range, showed pH sensitivity and relatively small changes of equilibrium swelling with temperature, which varied with PEGDMA molecular weight. The glass transition temperatures (T (g)) of P(HEA/IA/PEGDMA) networks were in the range 28.1-36.9 A degrees C, respectively, and also dependent on copolymer composition. Due to good biocompatibility, favorable swelling, and thermal properties these hydrogels show good potential for biomedical uses.", publisher = "Springer, New York", journal = "Polymer Bulletin", title = "Hemocompatibility, swelling and thermal properties of hydrogels based on 2-hydroxyethyl acrylate, itaconic acid and poly(ethylene glycol) dimethacrylate", pages = "2909-2895", number = "10", volume = "70", doi = "10.1007/s00289-013-0995-z" }
Tomić, S., Jovašević, J. S.,& Filipović, J. M.. (2013). Hemocompatibility, swelling and thermal properties of hydrogels based on 2-hydroxyethyl acrylate, itaconic acid and poly(ethylene glycol) dimethacrylate. in Polymer Bulletin Springer, New York., 70(10), 2895-2909. https://doi.org/10.1007/s00289-013-0995-z
Tomić S, Jovašević JS, Filipović JM. Hemocompatibility, swelling and thermal properties of hydrogels based on 2-hydroxyethyl acrylate, itaconic acid and poly(ethylene glycol) dimethacrylate. in Polymer Bulletin. 2013;70(10):2895-2909. doi:10.1007/s00289-013-0995-z .
Tomić, Simonida, Jovašević, Jovana S., Filipović, Jovanka M., "Hemocompatibility, swelling and thermal properties of hydrogels based on 2-hydroxyethyl acrylate, itaconic acid and poly(ethylene glycol) dimethacrylate" in Polymer Bulletin, 70, no. 10 (2013):2895-2909, https://doi.org/10.1007/s00289-013-0995-z . .