Technetium-99m labeling of hippuric and p-amino-hippuric acid in the presence of DTPA: Biological and pharmacokinetic evaluation and comparison with Tc-99m-DTPA
Samo za registrovane korisnike
1999
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Tc-99m-Hipp as a modified Tc-99m-DTpA, and Tc-99m-PAH as a new renal agent are developed. Each veal of lyophilised kit contain hippuric (Hipp) or p-aminohippuric acid (PAH), diethyltriaminepentaacetic acid as calciumtrisodium salt (CaNa(3)DTPA) and stannouschloride (SnCl2. xH(2)O), in molar ratio Hipp/PAH:DTPA = 4:1. They are high radiochemical purity radiopharmaceuticals, with hydrophilic character and low percentage of protein binding. The ITL chromatography and HPLC analyses of these labeled compounds have shown almost identical results as Tc-99m-DTPA, but their biological behavior in rats confirm certain differences. Tc-99m-Hipp is a renal agent clearing by the glomerular system, with better pharmacokinetical parameters than Tc-99m-DTPA: t(1/2(alpha)) = 4.1 min, t(1/2(beta)) = 198.6 min, K-d = 1.2.10(-2)min(-1) and a twofold value for blood clearance (Cl=2.07 ml/min). Tc-99m-PAH is a quite different renal agent, rapidly secreted by kidney as a tubular secretion agent. Its pharmacok...inetical parameters: t(1/2(alpha)) = 2.5 min, t(1/2(beta)) = 41.7 min and K-cl = 5.1.10(-4) min(-1) are almost equal to those of Tc-99m-MAG(3), but the blood clearance of Cl = 5.22 ml/min is even higher than that of IOH clearance.
Izvor:
Journal of Radioanalytical and Nuclear Chemistry, 1999, 242, 2, 279-285Izdavač:
- Springer, Dordrecht
DOI: 10.1007/BF02345554
ISSN: 0236-5731
WoS: 000083559400006
Scopus: 2-s2.0-0032753130
Institucija/grupa
Tehnološko-metalurški fakultetTY - JOUR AU - Đokić, Divna Đ. AU - Janković, Drina AU - Maksin, Tatjana N. AU - Onjia, Antonije PY - 1999 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/256 AB - Tc-99m-Hipp as a modified Tc-99m-DTpA, and Tc-99m-PAH as a new renal agent are developed. Each veal of lyophilised kit contain hippuric (Hipp) or p-aminohippuric acid (PAH), diethyltriaminepentaacetic acid as calciumtrisodium salt (CaNa(3)DTPA) and stannouschloride (SnCl2. xH(2)O), in molar ratio Hipp/PAH:DTPA = 4:1. They are high radiochemical purity radiopharmaceuticals, with hydrophilic character and low percentage of protein binding. The ITL chromatography and HPLC analyses of these labeled compounds have shown almost identical results as Tc-99m-DTPA, but their biological behavior in rats confirm certain differences. Tc-99m-Hipp is a renal agent clearing by the glomerular system, with better pharmacokinetical parameters than Tc-99m-DTPA: t(1/2(alpha)) = 4.1 min, t(1/2(beta)) = 198.6 min, K-d = 1.2.10(-2)min(-1) and a twofold value for blood clearance (Cl=2.07 ml/min). Tc-99m-PAH is a quite different renal agent, rapidly secreted by kidney as a tubular secretion agent. Its pharmacokinetical parameters: t(1/2(alpha)) = 2.5 min, t(1/2(beta)) = 41.7 min and K-cl = 5.1.10(-4) min(-1) are almost equal to those of Tc-99m-MAG(3), but the blood clearance of Cl = 5.22 ml/min is even higher than that of IOH clearance. PB - Springer, Dordrecht T2 - Journal of Radioanalytical and Nuclear Chemistry T1 - Technetium-99m labeling of hippuric and p-amino-hippuric acid in the presence of DTPA: Biological and pharmacokinetic evaluation and comparison with Tc-99m-DTPA EP - 285 IS - 2 SP - 279 VL - 242 DO - 10.1007/BF02345554 ER -
@article{ author = "Đokić, Divna Đ. and Janković, Drina and Maksin, Tatjana N. and Onjia, Antonije", year = "1999", abstract = "Tc-99m-Hipp as a modified Tc-99m-DTpA, and Tc-99m-PAH as a new renal agent are developed. Each veal of lyophilised kit contain hippuric (Hipp) or p-aminohippuric acid (PAH), diethyltriaminepentaacetic acid as calciumtrisodium salt (CaNa(3)DTPA) and stannouschloride (SnCl2. xH(2)O), in molar ratio Hipp/PAH:DTPA = 4:1. They are high radiochemical purity radiopharmaceuticals, with hydrophilic character and low percentage of protein binding. The ITL chromatography and HPLC analyses of these labeled compounds have shown almost identical results as Tc-99m-DTPA, but their biological behavior in rats confirm certain differences. Tc-99m-Hipp is a renal agent clearing by the glomerular system, with better pharmacokinetical parameters than Tc-99m-DTPA: t(1/2(alpha)) = 4.1 min, t(1/2(beta)) = 198.6 min, K-d = 1.2.10(-2)min(-1) and a twofold value for blood clearance (Cl=2.07 ml/min). Tc-99m-PAH is a quite different renal agent, rapidly secreted by kidney as a tubular secretion agent. Its pharmacokinetical parameters: t(1/2(alpha)) = 2.5 min, t(1/2(beta)) = 41.7 min and K-cl = 5.1.10(-4) min(-1) are almost equal to those of Tc-99m-MAG(3), but the blood clearance of Cl = 5.22 ml/min is even higher than that of IOH clearance.", publisher = "Springer, Dordrecht", journal = "Journal of Radioanalytical and Nuclear Chemistry", title = "Technetium-99m labeling of hippuric and p-amino-hippuric acid in the presence of DTPA: Biological and pharmacokinetic evaluation and comparison with Tc-99m-DTPA", pages = "285-279", number = "2", volume = "242", doi = "10.1007/BF02345554" }
Đokić, D. Đ., Janković, D., Maksin, T. N.,& Onjia, A.. (1999). Technetium-99m labeling of hippuric and p-amino-hippuric acid in the presence of DTPA: Biological and pharmacokinetic evaluation and comparison with Tc-99m-DTPA. in Journal of Radioanalytical and Nuclear Chemistry Springer, Dordrecht., 242(2), 279-285. https://doi.org/10.1007/BF02345554
Đokić DĐ, Janković D, Maksin TN, Onjia A. Technetium-99m labeling of hippuric and p-amino-hippuric acid in the presence of DTPA: Biological and pharmacokinetic evaluation and comparison with Tc-99m-DTPA. in Journal of Radioanalytical and Nuclear Chemistry. 1999;242(2):279-285. doi:10.1007/BF02345554 .
Đokić, Divna Đ., Janković, Drina, Maksin, Tatjana N., Onjia, Antonije, "Technetium-99m labeling of hippuric and p-amino-hippuric acid in the presence of DTPA: Biological and pharmacokinetic evaluation and comparison with Tc-99m-DTPA" in Journal of Radioanalytical and Nuclear Chemistry, 242, no. 2 (1999):279-285, https://doi.org/10.1007/BF02345554 . .