Efficacy of pastes containing CPP-ACP and CPP-ACFP in patients with Sjogren's syndrome
Само за регистроване кориснике
2015
Аутори
Perić, TamaraMarković, Dejan
Petrović, Bojan
Radojević, Vesna
Todorović, Tatjana
Anđelski-Radičević, Biljana
Jančić-Heinemann, Radmila
Susić, Gordana
Perić‐Popadić, Aleksandra
Tomić-Spirić, Vesna
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The purpose of this study was to evaluate efficacy of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and casein phosphopeptide-amorphous calcium fluoride phosphate (CPP-ACFP) containing pastes among individuals with Sjogren's syndrome (SS). Thirty patients were randomised into three groups: CPP-ACP, CPP-ACFP, and 0.05 % NaF to be used two times a day during a 28-day experimental period. Saliva was analysed for flow rate, pH, buffering capacity and mineral concentrations. Dental plaque was examined for pH. Following the formation of artificial carious lesion, participants wore enamel slabs for an in situ remineralisation study. Remineralisation potential was examined using scanning electron microscope (SEM) and energy dispersive spectroscopic (EDS) technique. SE microphotographs were subsequently analysed for area, diameter, perimeter, roundness and the number of enamel defects and percentage of tooth surface affected by defects. At the end of the experimental period, a sli...ght increase of salivary pH could have been observed. No differences in mineral composition of saliva were noted. The use of CPP-ACP and CPP-ACFP contributed to a significant rise of plaque pH. Image analysis revealed excessive reduction of defects' dimensions in the three experimental groups, and a decrease of the number of enamel defects in the CPP-ACP and CPP-ACFP groups. The EDS analysis did not show differences in Ca/P, Ca/O and P/O ratios in any of the treatment groups. CPP-ACP and CPP-ACFP hold promise as remineralising agents for patients with SS. Pastes containing CPP-ACP/CPP-ACFP show enhanced remineralisation potential compared with NaF mouthrinse in patients with SS.
Кључне речи:
Casein phosphopeptide-amorphous calcium phosphate / Casein phosphopeptide-amorphous calcium fluoride phosphate / Sjogren's syndrome / Saliva / Dental plaque / Enamel remineralisationИзвор:
Clinical Oral Investigations, 2015, 19, 9, 2153-2165Издавач:
- Springer Heidelberg, Heidelberg
DOI: 10.1007/s00784-015-1444-1
ISSN: 1432-6981
PubMed: 25762499
WoS: 000365519800001
Scopus: 2-s2.0-84948113270
Институција/група
Tehnološko-metalurški fakultetTY - JOUR AU - Perić, Tamara AU - Marković, Dejan AU - Petrović, Bojan AU - Radojević, Vesna AU - Todorović, Tatjana AU - Anđelski-Radičević, Biljana AU - Jančić-Heinemann, Radmila AU - Susić, Gordana AU - Perić‐Popadić, Aleksandra AU - Tomić-Spirić, Vesna PY - 2015 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3101 AB - The purpose of this study was to evaluate efficacy of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and casein phosphopeptide-amorphous calcium fluoride phosphate (CPP-ACFP) containing pastes among individuals with Sjogren's syndrome (SS). Thirty patients were randomised into three groups: CPP-ACP, CPP-ACFP, and 0.05 % NaF to be used two times a day during a 28-day experimental period. Saliva was analysed for flow rate, pH, buffering capacity and mineral concentrations. Dental plaque was examined for pH. Following the formation of artificial carious lesion, participants wore enamel slabs for an in situ remineralisation study. Remineralisation potential was examined using scanning electron microscope (SEM) and energy dispersive spectroscopic (EDS) technique. SE microphotographs were subsequently analysed for area, diameter, perimeter, roundness and the number of enamel defects and percentage of tooth surface affected by defects. At the end of the experimental period, a slight increase of salivary pH could have been observed. No differences in mineral composition of saliva were noted. The use of CPP-ACP and CPP-ACFP contributed to a significant rise of plaque pH. Image analysis revealed excessive reduction of defects' dimensions in the three experimental groups, and a decrease of the number of enamel defects in the CPP-ACP and CPP-ACFP groups. The EDS analysis did not show differences in Ca/P, Ca/O and P/O ratios in any of the treatment groups. CPP-ACP and CPP-ACFP hold promise as remineralising agents for patients with SS. Pastes containing CPP-ACP/CPP-ACFP show enhanced remineralisation potential compared with NaF mouthrinse in patients with SS. PB - Springer Heidelberg, Heidelberg T2 - Clinical Oral Investigations T1 - Efficacy of pastes containing CPP-ACP and CPP-ACFP in patients with Sjogren's syndrome EP - 2165 IS - 9 SP - 2153 VL - 19 DO - 10.1007/s00784-015-1444-1 ER -
@article{ author = "Perić, Tamara and Marković, Dejan and Petrović, Bojan and Radojević, Vesna and Todorović, Tatjana and Anđelski-Radičević, Biljana and Jančić-Heinemann, Radmila and Susić, Gordana and Perić‐Popadić, Aleksandra and Tomić-Spirić, Vesna", year = "2015", abstract = "The purpose of this study was to evaluate efficacy of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and casein phosphopeptide-amorphous calcium fluoride phosphate (CPP-ACFP) containing pastes among individuals with Sjogren's syndrome (SS). Thirty patients were randomised into three groups: CPP-ACP, CPP-ACFP, and 0.05 % NaF to be used two times a day during a 28-day experimental period. Saliva was analysed for flow rate, pH, buffering capacity and mineral concentrations. Dental plaque was examined for pH. Following the formation of artificial carious lesion, participants wore enamel slabs for an in situ remineralisation study. Remineralisation potential was examined using scanning electron microscope (SEM) and energy dispersive spectroscopic (EDS) technique. SE microphotographs were subsequently analysed for area, diameter, perimeter, roundness and the number of enamel defects and percentage of tooth surface affected by defects. At the end of the experimental period, a slight increase of salivary pH could have been observed. No differences in mineral composition of saliva were noted. The use of CPP-ACP and CPP-ACFP contributed to a significant rise of plaque pH. Image analysis revealed excessive reduction of defects' dimensions in the three experimental groups, and a decrease of the number of enamel defects in the CPP-ACP and CPP-ACFP groups. The EDS analysis did not show differences in Ca/P, Ca/O and P/O ratios in any of the treatment groups. CPP-ACP and CPP-ACFP hold promise as remineralising agents for patients with SS. Pastes containing CPP-ACP/CPP-ACFP show enhanced remineralisation potential compared with NaF mouthrinse in patients with SS.", publisher = "Springer Heidelberg, Heidelberg", journal = "Clinical Oral Investigations", title = "Efficacy of pastes containing CPP-ACP and CPP-ACFP in patients with Sjogren's syndrome", pages = "2165-2153", number = "9", volume = "19", doi = "10.1007/s00784-015-1444-1" }
Perić, T., Marković, D., Petrović, B., Radojević, V., Todorović, T., Anđelski-Radičević, B., Jančić-Heinemann, R., Susić, G., Perić‐Popadić, A.,& Tomić-Spirić, V.. (2015). Efficacy of pastes containing CPP-ACP and CPP-ACFP in patients with Sjogren's syndrome. in Clinical Oral Investigations Springer Heidelberg, Heidelberg., 19(9), 2153-2165. https://doi.org/10.1007/s00784-015-1444-1
Perić T, Marković D, Petrović B, Radojević V, Todorović T, Anđelski-Radičević B, Jančić-Heinemann R, Susić G, Perić‐Popadić A, Tomić-Spirić V. Efficacy of pastes containing CPP-ACP and CPP-ACFP in patients with Sjogren's syndrome. in Clinical Oral Investigations. 2015;19(9):2153-2165. doi:10.1007/s00784-015-1444-1 .
Perić, Tamara, Marković, Dejan, Petrović, Bojan, Radojević, Vesna, Todorović, Tatjana, Anđelski-Radičević, Biljana, Jančić-Heinemann, Radmila, Susić, Gordana, Perić‐Popadić, Aleksandra, Tomić-Spirić, Vesna, "Efficacy of pastes containing CPP-ACP and CPP-ACFP in patients with Sjogren's syndrome" in Clinical Oral Investigations, 19, no. 9 (2015):2153-2165, https://doi.org/10.1007/s00784-015-1444-1 . .