Fullerenol-Capped Porous Silica Nanoparticles for pH-Responsive Drug Delivery
2015
Autori
Knežević, Nikola Ž.Milenković, Sanja
Jović, Danica
Lazarević, Slavica
Mrđanović, Jasminka
Đorđević, Aleksandar
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Novel nanocomposite containing fullerenol nanoparticles (FNP) and porous silica nanoparticles (PSNs) was constructed and characterized. The capability of FNP to serve as a pore-capping agent and for entrapping 9-aminoacridine (9-AA) inside the pores of the PSN material was also demonstrated. Nitrogen sorption measurements evidence the successful capping of the silica pores while thermogravimetric analysis of FNP loaded PSN indicates the existence of pore-loaded fullerenol molecules. Higher amount of the drug release was noted by exposing the material to weakly acidic conditions in comparison to physiological pH, which may find application in targeted treatment of weakly acidic tumor tissues.
Izvor:
Advances in Materials Science and Engineering, 2015, 2015Izdavač:
- Hindawi Ltd, London
Finansiranje / projekti:
- Funkcionalni, funkcionalizovani i usavršeni nano materijali (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45005)
- Sinteza, razvoj tehnologija dobijanja i primena nanostrukturnih multifunkcionalnih materijala definisanih svojstava (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45019)
DOI: 10.1155/2015/567350
ISSN: 1687-8434
WoS: 000358954100001
Scopus: 2-s2.0-84938614379
Institucija/grupa
Tehnološko-metalurški fakultetTY - JOUR AU - Knežević, Nikola Ž. AU - Milenković, Sanja AU - Jović, Danica AU - Lazarević, Slavica AU - Mrđanović, Jasminka AU - Đorđević, Aleksandar PY - 2015 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3130 AB - Novel nanocomposite containing fullerenol nanoparticles (FNP) and porous silica nanoparticles (PSNs) was constructed and characterized. The capability of FNP to serve as a pore-capping agent and for entrapping 9-aminoacridine (9-AA) inside the pores of the PSN material was also demonstrated. Nitrogen sorption measurements evidence the successful capping of the silica pores while thermogravimetric analysis of FNP loaded PSN indicates the existence of pore-loaded fullerenol molecules. Higher amount of the drug release was noted by exposing the material to weakly acidic conditions in comparison to physiological pH, which may find application in targeted treatment of weakly acidic tumor tissues. PB - Hindawi Ltd, London T2 - Advances in Materials Science and Engineering T1 - Fullerenol-Capped Porous Silica Nanoparticles for pH-Responsive Drug Delivery VL - 2015 DO - 10.1155/2015/567350 ER -
@article{ author = "Knežević, Nikola Ž. and Milenković, Sanja and Jović, Danica and Lazarević, Slavica and Mrđanović, Jasminka and Đorđević, Aleksandar", year = "2015", abstract = "Novel nanocomposite containing fullerenol nanoparticles (FNP) and porous silica nanoparticles (PSNs) was constructed and characterized. The capability of FNP to serve as a pore-capping agent and for entrapping 9-aminoacridine (9-AA) inside the pores of the PSN material was also demonstrated. Nitrogen sorption measurements evidence the successful capping of the silica pores while thermogravimetric analysis of FNP loaded PSN indicates the existence of pore-loaded fullerenol molecules. Higher amount of the drug release was noted by exposing the material to weakly acidic conditions in comparison to physiological pH, which may find application in targeted treatment of weakly acidic tumor tissues.", publisher = "Hindawi Ltd, London", journal = "Advances in Materials Science and Engineering", title = "Fullerenol-Capped Porous Silica Nanoparticles for pH-Responsive Drug Delivery", volume = "2015", doi = "10.1155/2015/567350" }
Knežević, N. Ž., Milenković, S., Jović, D., Lazarević, S., Mrđanović, J.,& Đorđević, A.. (2015). Fullerenol-Capped Porous Silica Nanoparticles for pH-Responsive Drug Delivery. in Advances in Materials Science and Engineering Hindawi Ltd, London., 2015. https://doi.org/10.1155/2015/567350
Knežević NŽ, Milenković S, Jović D, Lazarević S, Mrđanović J, Đorđević A. Fullerenol-Capped Porous Silica Nanoparticles for pH-Responsive Drug Delivery. in Advances in Materials Science and Engineering. 2015;2015. doi:10.1155/2015/567350 .
Knežević, Nikola Ž., Milenković, Sanja, Jović, Danica, Lazarević, Slavica, Mrđanović, Jasminka, Đorđević, Aleksandar, "Fullerenol-Capped Porous Silica Nanoparticles for pH-Responsive Drug Delivery" in Advances in Materials Science and Engineering, 2015 (2015), https://doi.org/10.1155/2015/567350 . .