A Chemometrical Analysis of Voltammetric Data for Simultaneous Determination of Phenobarbital Sodium and Paracetamol Obtained at a Gold Electrode
2016
Autori
Avramov-Ivić, MilkaAntanasijević, Jelena
Trišović, Nemanja
Antanasijević, Davor
Lović, Jelena
Mijin, Dušan
Petrović, Slobodan
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The electrochemical behavior of phenobarbital sodium (PBS), paracetamol (PCM) and their binary mixtures was investigated using cyclic voltammetry (CV) and square wave voltammetry (SWV) at a bare gold electrode in a 0.05 M bicarbonate solution. A calibration curve of PBS obtained by SWV had two linear ranges, from 1.0 to 3.0 mu M and from 5.0 to 35.0 mu M with a limit of quantification (LOQ) of 0.62 mu M and a limit of detection (LOD) of 0.19 mu M, while a calibration curve of PCM was determined within the range from 10.0 to 50.0 mu M with a LOQ of 8.53 mu M and a LOD of 2.56 mu M. Both drugs underwent oxidation by irreversible, diffusion controlled process. The SW voltammograms of the drug mixtures produced complex, overlapping profiles and a chemometric method was applied for their decomposition. Two different artificial neural network (ANN) architectures, namely back-propagation neural network (BPNN) and general regression neural network (GRNN) were employed for the simultaneous pred...iction of the concentrations of the drugs in a synthetic sample. The BPNN model had higher accuracy (mean absolute percentage error values were in the range of 3.6-8.4%) and thus it can be used for the simultaneous determination of PBS and PCM.
Ključne reči:
phenobarbital / paracetamol / voltammetry / chemometricsIzvor:
International Journal of Electrochemical Science, 2016, 11, 7, 5935-5951Izdavač:
- Electrochemical Science Group, Beograd
Finansiranje / projekti:
- Proučavanje sinteze, strukture i aktivnosti organskih jedinjenja prirodnog i sintetskog porekla (RS-172013)
- Nov pristup dizajniranju materijala za konverziju i skladištenje energije (RS-172060)
- Razvoj i primena metoda i materijala za monitoring novih zagađujućih i toksičnih organskih materija i teških metala (RS-172007)
DOI: 10.20964/2016.07.48
ISSN: 1452-3981
WoS: 000384905600050
Scopus: 2-s2.0-84978138152
Institucija/grupa
Tehnološko-metalurški fakultetTY - JOUR AU - Avramov-Ivić, Milka AU - Antanasijević, Jelena AU - Trišović, Nemanja AU - Antanasijević, Davor AU - Lović, Jelena AU - Mijin, Dušan AU - Petrović, Slobodan PY - 2016 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3358 AB - The electrochemical behavior of phenobarbital sodium (PBS), paracetamol (PCM) and their binary mixtures was investigated using cyclic voltammetry (CV) and square wave voltammetry (SWV) at a bare gold electrode in a 0.05 M bicarbonate solution. A calibration curve of PBS obtained by SWV had two linear ranges, from 1.0 to 3.0 mu M and from 5.0 to 35.0 mu M with a limit of quantification (LOQ) of 0.62 mu M and a limit of detection (LOD) of 0.19 mu M, while a calibration curve of PCM was determined within the range from 10.0 to 50.0 mu M with a LOQ of 8.53 mu M and a LOD of 2.56 mu M. Both drugs underwent oxidation by irreversible, diffusion controlled process. The SW voltammograms of the drug mixtures produced complex, overlapping profiles and a chemometric method was applied for their decomposition. Two different artificial neural network (ANN) architectures, namely back-propagation neural network (BPNN) and general regression neural network (GRNN) were employed for the simultaneous prediction of the concentrations of the drugs in a synthetic sample. The BPNN model had higher accuracy (mean absolute percentage error values were in the range of 3.6-8.4%) and thus it can be used for the simultaneous determination of PBS and PCM. PB - Electrochemical Science Group, Beograd T2 - International Journal of Electrochemical Science T1 - A Chemometrical Analysis of Voltammetric Data for Simultaneous Determination of Phenobarbital Sodium and Paracetamol Obtained at a Gold Electrode EP - 5951 IS - 7 SP - 5935 VL - 11 DO - 10.20964/2016.07.48 ER -
@article{ author = "Avramov-Ivić, Milka and Antanasijević, Jelena and Trišović, Nemanja and Antanasijević, Davor and Lović, Jelena and Mijin, Dušan and Petrović, Slobodan", year = "2016", abstract = "The electrochemical behavior of phenobarbital sodium (PBS), paracetamol (PCM) and their binary mixtures was investigated using cyclic voltammetry (CV) and square wave voltammetry (SWV) at a bare gold electrode in a 0.05 M bicarbonate solution. A calibration curve of PBS obtained by SWV had two linear ranges, from 1.0 to 3.0 mu M and from 5.0 to 35.0 mu M with a limit of quantification (LOQ) of 0.62 mu M and a limit of detection (LOD) of 0.19 mu M, while a calibration curve of PCM was determined within the range from 10.0 to 50.0 mu M with a LOQ of 8.53 mu M and a LOD of 2.56 mu M. Both drugs underwent oxidation by irreversible, diffusion controlled process. The SW voltammograms of the drug mixtures produced complex, overlapping profiles and a chemometric method was applied for their decomposition. Two different artificial neural network (ANN) architectures, namely back-propagation neural network (BPNN) and general regression neural network (GRNN) were employed for the simultaneous prediction of the concentrations of the drugs in a synthetic sample. The BPNN model had higher accuracy (mean absolute percentage error values were in the range of 3.6-8.4%) and thus it can be used for the simultaneous determination of PBS and PCM.", publisher = "Electrochemical Science Group, Beograd", journal = "International Journal of Electrochemical Science", title = "A Chemometrical Analysis of Voltammetric Data for Simultaneous Determination of Phenobarbital Sodium and Paracetamol Obtained at a Gold Electrode", pages = "5951-5935", number = "7", volume = "11", doi = "10.20964/2016.07.48" }
Avramov-Ivić, M., Antanasijević, J., Trišović, N., Antanasijević, D., Lović, J., Mijin, D.,& Petrović, S.. (2016). A Chemometrical Analysis of Voltammetric Data for Simultaneous Determination of Phenobarbital Sodium and Paracetamol Obtained at a Gold Electrode. in International Journal of Electrochemical Science Electrochemical Science Group, Beograd., 11(7), 5935-5951. https://doi.org/10.20964/2016.07.48
Avramov-Ivić M, Antanasijević J, Trišović N, Antanasijević D, Lović J, Mijin D, Petrović S. A Chemometrical Analysis of Voltammetric Data for Simultaneous Determination of Phenobarbital Sodium and Paracetamol Obtained at a Gold Electrode. in International Journal of Electrochemical Science. 2016;11(7):5935-5951. doi:10.20964/2016.07.48 .
Avramov-Ivić, Milka, Antanasijević, Jelena, Trišović, Nemanja, Antanasijević, Davor, Lović, Jelena, Mijin, Dušan, Petrović, Slobodan, "A Chemometrical Analysis of Voltammetric Data for Simultaneous Determination of Phenobarbital Sodium and Paracetamol Obtained at a Gold Electrode" in International Journal of Electrochemical Science, 11, no. 7 (2016):5935-5951, https://doi.org/10.20964/2016.07.48 . .