Hydroxylated fullerene-capped, vinblastine-loaded folic acid-functionalized mesoporous silica nanoparticles for targeted anticancer therapy
Authors
Knežević, Nikola Ž.Mrdanović, Jasminka
Borisev, Ivana
Milenković, Sanja
Janaćković, Đorđe
Cunin, Frederique
Đorđević, Aleksandar
Article (Published version)
Metadata
Show full item recordAbstract
A novel cancer-targeting drug delivery system is constructed and characterized, based on folic acid-functionalized mesoporous silica nanoparticles with pore-loaded anticancer drug vinblastine and pore-blocking fullerenol molecules. The selective treatment efficacy based on targeting of cancer-verexpressed folate receptors is demonstrated by comparison of cell viability upon the treatment of healthy MRC-5, breast cancer MCF-7 and cervical cancer HeLa cells, which are known to differ in the amount of folate receptors on their surfaces.
Source:
RSC Advances, 2016, 6, 9, 7061-7065Publisher:
- Royal Society of Chemistry
Funding / projects:
- Functional, Functionalized and Advanced Nanomaterials (RS-45005)
- Synthesis, processing and applications of nanostructured multifunctional materials with defined properties (RS-45019)
DOI: 10.1039/c5ra22937e
ISSN: 2046-2069
WoS: 000369515500025
Scopus: 2-s2.0-84977261333
Institution/Community
Tehnološko-metalurški fakultetTY - JOUR AU - Knežević, Nikola Ž. AU - Mrdanović, Jasminka AU - Borisev, Ivana AU - Milenković, Sanja AU - Janaćković, Đorđe AU - Cunin, Frederique AU - Đorđević, Aleksandar PY - 2016 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3386 AB - A novel cancer-targeting drug delivery system is constructed and characterized, based on folic acid-functionalized mesoporous silica nanoparticles with pore-loaded anticancer drug vinblastine and pore-blocking fullerenol molecules. The selective treatment efficacy based on targeting of cancer-verexpressed folate receptors is demonstrated by comparison of cell viability upon the treatment of healthy MRC-5, breast cancer MCF-7 and cervical cancer HeLa cells, which are known to differ in the amount of folate receptors on their surfaces. PB - Royal Society of Chemistry T2 - RSC Advances T1 - Hydroxylated fullerene-capped, vinblastine-loaded folic acid-functionalized mesoporous silica nanoparticles for targeted anticancer therapy EP - 7065 IS - 9 SP - 7061 VL - 6 DO - 10.1039/c5ra22937e ER -
@article{ author = "Knežević, Nikola Ž. and Mrdanović, Jasminka and Borisev, Ivana and Milenković, Sanja and Janaćković, Đorđe and Cunin, Frederique and Đorđević, Aleksandar", year = "2016", abstract = "A novel cancer-targeting drug delivery system is constructed and characterized, based on folic acid-functionalized mesoporous silica nanoparticles with pore-loaded anticancer drug vinblastine and pore-blocking fullerenol molecules. The selective treatment efficacy based on targeting of cancer-verexpressed folate receptors is demonstrated by comparison of cell viability upon the treatment of healthy MRC-5, breast cancer MCF-7 and cervical cancer HeLa cells, which are known to differ in the amount of folate receptors on their surfaces.", publisher = "Royal Society of Chemistry", journal = "RSC Advances", title = "Hydroxylated fullerene-capped, vinblastine-loaded folic acid-functionalized mesoporous silica nanoparticles for targeted anticancer therapy", pages = "7065-7061", number = "9", volume = "6", doi = "10.1039/c5ra22937e" }
Knežević, N. Ž., Mrdanović, J., Borisev, I., Milenković, S., Janaćković, Đ., Cunin, F.,& Đorđević, A.. (2016). Hydroxylated fullerene-capped, vinblastine-loaded folic acid-functionalized mesoporous silica nanoparticles for targeted anticancer therapy. in RSC Advances Royal Society of Chemistry., 6(9), 7061-7065. https://doi.org/10.1039/c5ra22937e
Knežević NŽ, Mrdanović J, Borisev I, Milenković S, Janaćković Đ, Cunin F, Đorđević A. Hydroxylated fullerene-capped, vinblastine-loaded folic acid-functionalized mesoporous silica nanoparticles for targeted anticancer therapy. in RSC Advances. 2016;6(9):7061-7065. doi:10.1039/c5ra22937e .
Knežević, Nikola Ž., Mrdanović, Jasminka, Borisev, Ivana, Milenković, Sanja, Janaćković, Đorđe, Cunin, Frederique, Đorđević, Aleksandar, "Hydroxylated fullerene-capped, vinblastine-loaded folic acid-functionalized mesoporous silica nanoparticles for targeted anticancer therapy" in RSC Advances, 6, no. 9 (2016):7061-7065, https://doi.org/10.1039/c5ra22937e . .