Supercritical CO2 sorption kinetics and thymol impregnation of PCL and PCL-HA
Authorized Users Only
2016
Authors
Ivanović, JasnaKnauer, Sandra
Fanovich, Alejandra
Milovanović, Stoja
Stamenić, Marko
Jaeger, Philip
Žižović, Irena
Eggers, Rudolf
Article (Published version)
Metadata
Show full item recordAbstract
The potential of supercritical carbon dioxide (scCO(2)) processing of polycaprolactone (Pa) and polycaprolactone-hydroxyapatite (PCL-HA) composites for obtaining functional porous scaffolds at moderate temperatures (35-40 degrees C) was analyzed and quantified. The effect of scCO(2) sorption kinetics on the swelling, foam morphology and thermal behavior of the PCL and PCL-HA composites was studied. Sorption isotherms were determined using magnetic suspension balance at 10-30 MPa and 35-40 degrees C. Influence of the pressure, HA amount (10-20%) and procedure for HA powder preparation on the sorption kinetics was discussed. Supercritical solvent impregnation (SSI) of PCL and PCL-HA with thymol was investigated as environmentally friendly way to produce functional scaffolds with controlled microstructure. Moderately high pressures (13-17 MPa) and 10% of HA were proven to be favorable for creation of the PCL scaffolds with satisfying foam microstructure (mean pore size similar to 200-300 ...mu m), filler distribution and thymol impregnation yields (12-18%). This was due to the satisfactory high scCO(2) solubility (0.25-0.30 g/g) and mass transfer rate (similar to 10(-10) m(2)/s) in the polymer phase as well as its great plasticizing effect (-Delta T-m = 26.4-27.4 degrees C). Higher saturation of the polymer phase with scCO(2) (0.30-0.55 g/g), filler amount (20%) and thymol solubility in scCO(2) ( gt 5.5 g/kg) at pressures above 20 MPa resulted in decreased mass transfer rate and SSI efficiency.
Keywords:
Polycaprolactone / Polycaprolactone-hydroxyapatite / CO2 sorption kinetics / High-pressure DSC / Melting point depression / Thymol impregnationSource:
Journal of Supercritical Fluids, 2016, 107, 486-498Publisher:
- Elsevier, Amsterdam
Funding / projects:
- Eurotechnica GmbH (Bargteheide,Germany)
- TuTech Innovation GmbH
- Functional physiologically active plant materials with additional values for application in pharmaceutical and food industry (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45017)
- TUHH (Hamburg, Germany)
DOI: 10.1016/j.supflu.2015.07.001
ISSN: 0896-8446
WoS: 000366077100058
Scopus: 2-s2.0-84947487391
Institution/Community
Tehnološko-metalurški fakultetTY - JOUR AU - Ivanović, Jasna AU - Knauer, Sandra AU - Fanovich, Alejandra AU - Milovanović, Stoja AU - Stamenić, Marko AU - Jaeger, Philip AU - Žižović, Irena AU - Eggers, Rudolf PY - 2016 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3407 AB - The potential of supercritical carbon dioxide (scCO(2)) processing of polycaprolactone (Pa) and polycaprolactone-hydroxyapatite (PCL-HA) composites for obtaining functional porous scaffolds at moderate temperatures (35-40 degrees C) was analyzed and quantified. The effect of scCO(2) sorption kinetics on the swelling, foam morphology and thermal behavior of the PCL and PCL-HA composites was studied. Sorption isotherms were determined using magnetic suspension balance at 10-30 MPa and 35-40 degrees C. Influence of the pressure, HA amount (10-20%) and procedure for HA powder preparation on the sorption kinetics was discussed. Supercritical solvent impregnation (SSI) of PCL and PCL-HA with thymol was investigated as environmentally friendly way to produce functional scaffolds with controlled microstructure. Moderately high pressures (13-17 MPa) and 10% of HA were proven to be favorable for creation of the PCL scaffolds with satisfying foam microstructure (mean pore size similar to 200-300 mu m), filler distribution and thymol impregnation yields (12-18%). This was due to the satisfactory high scCO(2) solubility (0.25-0.30 g/g) and mass transfer rate (similar to 10(-10) m(2)/s) in the polymer phase as well as its great plasticizing effect (-Delta T-m = 26.4-27.4 degrees C). Higher saturation of the polymer phase with scCO(2) (0.30-0.55 g/g), filler amount (20%) and thymol solubility in scCO(2) ( gt 5.5 g/kg) at pressures above 20 MPa resulted in decreased mass transfer rate and SSI efficiency. PB - Elsevier, Amsterdam T2 - Journal of Supercritical Fluids T1 - Supercritical CO2 sorption kinetics and thymol impregnation of PCL and PCL-HA EP - 498 SP - 486 VL - 107 DO - 10.1016/j.supflu.2015.07.001 ER -
@article{ author = "Ivanović, Jasna and Knauer, Sandra and Fanovich, Alejandra and Milovanović, Stoja and Stamenić, Marko and Jaeger, Philip and Žižović, Irena and Eggers, Rudolf", year = "2016", abstract = "The potential of supercritical carbon dioxide (scCO(2)) processing of polycaprolactone (Pa) and polycaprolactone-hydroxyapatite (PCL-HA) composites for obtaining functional porous scaffolds at moderate temperatures (35-40 degrees C) was analyzed and quantified. The effect of scCO(2) sorption kinetics on the swelling, foam morphology and thermal behavior of the PCL and PCL-HA composites was studied. Sorption isotherms were determined using magnetic suspension balance at 10-30 MPa and 35-40 degrees C. Influence of the pressure, HA amount (10-20%) and procedure for HA powder preparation on the sorption kinetics was discussed. Supercritical solvent impregnation (SSI) of PCL and PCL-HA with thymol was investigated as environmentally friendly way to produce functional scaffolds with controlled microstructure. Moderately high pressures (13-17 MPa) and 10% of HA were proven to be favorable for creation of the PCL scaffolds with satisfying foam microstructure (mean pore size similar to 200-300 mu m), filler distribution and thymol impregnation yields (12-18%). This was due to the satisfactory high scCO(2) solubility (0.25-0.30 g/g) and mass transfer rate (similar to 10(-10) m(2)/s) in the polymer phase as well as its great plasticizing effect (-Delta T-m = 26.4-27.4 degrees C). Higher saturation of the polymer phase with scCO(2) (0.30-0.55 g/g), filler amount (20%) and thymol solubility in scCO(2) ( gt 5.5 g/kg) at pressures above 20 MPa resulted in decreased mass transfer rate and SSI efficiency.", publisher = "Elsevier, Amsterdam", journal = "Journal of Supercritical Fluids", title = "Supercritical CO2 sorption kinetics and thymol impregnation of PCL and PCL-HA", pages = "498-486", volume = "107", doi = "10.1016/j.supflu.2015.07.001" }
Ivanović, J., Knauer, S., Fanovich, A., Milovanović, S., Stamenić, M., Jaeger, P., Žižović, I.,& Eggers, R.. (2016). Supercritical CO2 sorption kinetics and thymol impregnation of PCL and PCL-HA. in Journal of Supercritical Fluids Elsevier, Amsterdam., 107, 486-498. https://doi.org/10.1016/j.supflu.2015.07.001
Ivanović J, Knauer S, Fanovich A, Milovanović S, Stamenić M, Jaeger P, Žižović I, Eggers R. Supercritical CO2 sorption kinetics and thymol impregnation of PCL and PCL-HA. in Journal of Supercritical Fluids. 2016;107:486-498. doi:10.1016/j.supflu.2015.07.001 .
Ivanović, Jasna, Knauer, Sandra, Fanovich, Alejandra, Milovanović, Stoja, Stamenić, Marko, Jaeger, Philip, Žižović, Irena, Eggers, Rudolf, "Supercritical CO2 sorption kinetics and thymol impregnation of PCL and PCL-HA" in Journal of Supercritical Fluids, 107 (2016):486-498, https://doi.org/10.1016/j.supflu.2015.07.001 . .