Modeling of the metabolic energy dissipation for restricted tumor growth
Abstract
Energy dissipation mostly represents unwanted outcome but in the biochemical processes it may alter the biochemical pathways. However, it is rarely considered in the literature although energy dissipation and its alteration due to the changes in cell microenvironment may improve methods for guiding chemical and biochemical processes in the desired directions. Deeper insight into the changes of metabolic activity of tumor cells exposed to osmotic stress or irradiation may offer the possibility of tumor growth reduction. In this work effects of the osmotic stress and irradiation on the thermodynamical affinity of tumor cells and their damping effects on metabolic energy dissipation were investigated and modeled. Although many various models were applied to consider the tumor restrictive growth they have not considered the metabolic energy dissipation. In this work a pseudo rheological model in the form of "the metabolic spring-pot element" is formulated to describe theoretically the meta...bolic susceptibility of tumor spheroid. This analog model relates the thermodynamical affinity of cell growth with the volume expansion of tumor spheroid under isotropic loading conditions. Spheroid relaxation induces anomalous nature of the metabolic energy dissipation which causes the damping effects on cell growth. The proposed model can be used for determining the metabolic energy "structure" in the context of restrictive cell growth as well as for predicting optimal doses for cancer curing in order to tailor the clinical treatment for each person and each type of cancer.
Keywords:
Micro-environmentally restricted tumor growth / Thermodynamical affinity of cells, damping effects / Metabolic energy dissipation / Mathematical modellingSource:
Journal of Bioenergetics and Biomembranes, 2017, 49, 5, 381-389Publisher:
- Springer/Plenum Publishers, New York
Funding / projects:
DOI: 10.1007/s10863-017-9723-y
ISSN: 0145-479X
PubMed: 28852947
WoS: 000413324500004
Scopus: 2-s2.0-85028759738
Institution/Community
Tehnološko-metalurški fakultetTY - JOUR AU - Pajić-Lijaković, Ivana AU - Milivojević, Milan PY - 2017 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3636 AB - Energy dissipation mostly represents unwanted outcome but in the biochemical processes it may alter the biochemical pathways. However, it is rarely considered in the literature although energy dissipation and its alteration due to the changes in cell microenvironment may improve methods for guiding chemical and biochemical processes in the desired directions. Deeper insight into the changes of metabolic activity of tumor cells exposed to osmotic stress or irradiation may offer the possibility of tumor growth reduction. In this work effects of the osmotic stress and irradiation on the thermodynamical affinity of tumor cells and their damping effects on metabolic energy dissipation were investigated and modeled. Although many various models were applied to consider the tumor restrictive growth they have not considered the metabolic energy dissipation. In this work a pseudo rheological model in the form of "the metabolic spring-pot element" is formulated to describe theoretically the metabolic susceptibility of tumor spheroid. This analog model relates the thermodynamical affinity of cell growth with the volume expansion of tumor spheroid under isotropic loading conditions. Spheroid relaxation induces anomalous nature of the metabolic energy dissipation which causes the damping effects on cell growth. The proposed model can be used for determining the metabolic energy "structure" in the context of restrictive cell growth as well as for predicting optimal doses for cancer curing in order to tailor the clinical treatment for each person and each type of cancer. PB - Springer/Plenum Publishers, New York T2 - Journal of Bioenergetics and Biomembranes T1 - Modeling of the metabolic energy dissipation for restricted tumor growth EP - 389 IS - 5 SP - 381 VL - 49 DO - 10.1007/s10863-017-9723-y ER -
@article{ author = "Pajić-Lijaković, Ivana and Milivojević, Milan", year = "2017", abstract = "Energy dissipation mostly represents unwanted outcome but in the biochemical processes it may alter the biochemical pathways. However, it is rarely considered in the literature although energy dissipation and its alteration due to the changes in cell microenvironment may improve methods for guiding chemical and biochemical processes in the desired directions. Deeper insight into the changes of metabolic activity of tumor cells exposed to osmotic stress or irradiation may offer the possibility of tumor growth reduction. In this work effects of the osmotic stress and irradiation on the thermodynamical affinity of tumor cells and their damping effects on metabolic energy dissipation were investigated and modeled. Although many various models were applied to consider the tumor restrictive growth they have not considered the metabolic energy dissipation. In this work a pseudo rheological model in the form of "the metabolic spring-pot element" is formulated to describe theoretically the metabolic susceptibility of tumor spheroid. This analog model relates the thermodynamical affinity of cell growth with the volume expansion of tumor spheroid under isotropic loading conditions. Spheroid relaxation induces anomalous nature of the metabolic energy dissipation which causes the damping effects on cell growth. The proposed model can be used for determining the metabolic energy "structure" in the context of restrictive cell growth as well as for predicting optimal doses for cancer curing in order to tailor the clinical treatment for each person and each type of cancer.", publisher = "Springer/Plenum Publishers, New York", journal = "Journal of Bioenergetics and Biomembranes", title = "Modeling of the metabolic energy dissipation for restricted tumor growth", pages = "389-381", number = "5", volume = "49", doi = "10.1007/s10863-017-9723-y" }
Pajić-Lijaković, I.,& Milivojević, M.. (2017). Modeling of the metabolic energy dissipation for restricted tumor growth. in Journal of Bioenergetics and Biomembranes Springer/Plenum Publishers, New York., 49(5), 381-389. https://doi.org/10.1007/s10863-017-9723-y
Pajić-Lijaković I, Milivojević M. Modeling of the metabolic energy dissipation for restricted tumor growth. in Journal of Bioenergetics and Biomembranes. 2017;49(5):381-389. doi:10.1007/s10863-017-9723-y .
Pajić-Lijaković, Ivana, Milivojević, Milan, "Modeling of the metabolic energy dissipation for restricted tumor growth" in Journal of Bioenergetics and Biomembranes, 49, no. 5 (2017):381-389, https://doi.org/10.1007/s10863-017-9723-y . .