Comparative Effects of Span 20 and Span 40 on Liposomes Release Properties
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2017
Authors
Pravilović, RadoslavaBalanč, Bojana
Trifković, Kata T.
Đorđević, Verica
Bošković-Vragolović, Nevenka
Bugarski, Branko
Pjanović, Rada
Article (Published version)
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Liposomes are known as convenient carriers for a broad range of actives. The release rate of actives can be adjusted/controlled by the addition of different surfactants. The aim of this study was to compare the effects of two surfactants, Span 20 and Span 40, on liposomes release properties. In particular, the study shows how the membrane modification affects the mass transfer resistances and liposome size compared with the common liposomes. The aqueous extract of thyme was used as a model substance. It is a valuable source of natural antioxidants - polyphenols. The diffusion of polyphenols from native thyme extract (un-encapsulated) and from different types of liposomes was conducted using Franz diffusion cell. The results were approximated with Fick's second law and they implied that liposomes modified with Span 20 provided the slowest release of polyphenolic compounds due to the highest value of mass transfer resistance (2.523 x 10(6) s/m).
Keywords:
diffusion / liposomes / resistance / release / thymeSource:
International Journal of Food Engineering, 2017, 13, 12Publisher:
- Walter de Gruyter Gmbh, Berlin
Funding / projects:
DOI: 10.1515/ijfe-2017-0339
ISSN: 2194-5764
WoS: 000418366700001
Scopus: 2-s2.0-85037724977
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Tehnološko-metalurški fakultetTY - JOUR AU - Pravilović, Radoslava AU - Balanč, Bojana AU - Trifković, Kata T. AU - Đorđević, Verica AU - Bošković-Vragolović, Nevenka AU - Bugarski, Branko AU - Pjanović, Rada PY - 2017 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3638 AB - Liposomes are known as convenient carriers for a broad range of actives. The release rate of actives can be adjusted/controlled by the addition of different surfactants. The aim of this study was to compare the effects of two surfactants, Span 20 and Span 40, on liposomes release properties. In particular, the study shows how the membrane modification affects the mass transfer resistances and liposome size compared with the common liposomes. The aqueous extract of thyme was used as a model substance. It is a valuable source of natural antioxidants - polyphenols. The diffusion of polyphenols from native thyme extract (un-encapsulated) and from different types of liposomes was conducted using Franz diffusion cell. The results were approximated with Fick's second law and they implied that liposomes modified with Span 20 provided the slowest release of polyphenolic compounds due to the highest value of mass transfer resistance (2.523 x 10(6) s/m). PB - Walter de Gruyter Gmbh, Berlin T2 - International Journal of Food Engineering T1 - Comparative Effects of Span 20 and Span 40 on Liposomes Release Properties IS - 12 VL - 13 DO - 10.1515/ijfe-2017-0339 ER -
@article{ author = "Pravilović, Radoslava and Balanč, Bojana and Trifković, Kata T. and Đorđević, Verica and Bošković-Vragolović, Nevenka and Bugarski, Branko and Pjanović, Rada", year = "2017", abstract = "Liposomes are known as convenient carriers for a broad range of actives. The release rate of actives can be adjusted/controlled by the addition of different surfactants. The aim of this study was to compare the effects of two surfactants, Span 20 and Span 40, on liposomes release properties. In particular, the study shows how the membrane modification affects the mass transfer resistances and liposome size compared with the common liposomes. The aqueous extract of thyme was used as a model substance. It is a valuable source of natural antioxidants - polyphenols. The diffusion of polyphenols from native thyme extract (un-encapsulated) and from different types of liposomes was conducted using Franz diffusion cell. The results were approximated with Fick's second law and they implied that liposomes modified with Span 20 provided the slowest release of polyphenolic compounds due to the highest value of mass transfer resistance (2.523 x 10(6) s/m).", publisher = "Walter de Gruyter Gmbh, Berlin", journal = "International Journal of Food Engineering", title = "Comparative Effects of Span 20 and Span 40 on Liposomes Release Properties", number = "12", volume = "13", doi = "10.1515/ijfe-2017-0339" }
Pravilović, R., Balanč, B., Trifković, K. T., Đorđević, V., Bošković-Vragolović, N., Bugarski, B.,& Pjanović, R.. (2017). Comparative Effects of Span 20 and Span 40 on Liposomes Release Properties. in International Journal of Food Engineering Walter de Gruyter Gmbh, Berlin., 13(12). https://doi.org/10.1515/ijfe-2017-0339
Pravilović R, Balanč B, Trifković KT, Đorđević V, Bošković-Vragolović N, Bugarski B, Pjanović R. Comparative Effects of Span 20 and Span 40 on Liposomes Release Properties. in International Journal of Food Engineering. 2017;13(12). doi:10.1515/ijfe-2017-0339 .
Pravilović, Radoslava, Balanč, Bojana, Trifković, Kata T., Đorđević, Verica, Bošković-Vragolović, Nevenka, Bugarski, Branko, Pjanović, Rada, "Comparative Effects of Span 20 and Span 40 on Liposomes Release Properties" in International Journal of Food Engineering, 13, no. 12 (2017), https://doi.org/10.1515/ijfe-2017-0339 . .