Sinteza, karakterizacija i ispitivanje antioksidativne aktivnosti estarskih i amidnih derivata 2,6-dimetil-4-supstituisane-1,4-dihidropiridin-3,5-dikarboksilne kiseline
Abstract
Six ester and amide derivates of 2,6-dimethyl-4-(substituted)-1,4-dihydropyridine-3,5-dicarboxylic acid have been synthesized in this paper, including: diethyl 2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate, diethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, diethyl 2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, diethyl 4-(2-hydroxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, diethyl 4-(3-hydroxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate and diethyl 4-(4-hydroxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate. Obtained ester derivates were used afterwards as a starting compounds for synthesis of amide derivates, including: 2,6-dimethyl-4-phenyl-N3,N5-di(thiazol-2-yl)-1,4-dihydropyridine-3,5-dicarboxamide, 2,6-dimethyl-4-(3-nitrophenyl)-N3,N5-di(thiazol-2-yl)-1,4-dihydropyridine-3,5-dicarboxamide, 2,6-dimethyl-4-(4-nitrophenyl)-N3,N5-di(thiazol-2-yl)-1,4-dihydropyridine-3,5-dicarboxam...ide, 4-(2-hydroxyphenyl)-2,6-dimethyl-N3,N5-di(thiazol-2-yl)-1,4-dihydropyridine-3,5-dicarboxamide, 4-(3-hydroxyphenyl)-2,6-dimethyl-N3,N5-di(thiazol-2-yl)-1,4-dihydropyridine-3,5-dicarboxamide and 4-(4-hydroxyphenyl)-2,6-dimethyl-N3,N5-di(thiazol-2-yl)-1,4-dihydropyridine-3,5-dicarboxamide. Obtained compounds were characterized by melting point, elementary analysis and FT-IR spectroscopy. In order to determine the effect of the substituent, the antioxidative activity assay of obtained 1,4-dihydropyridines was performed by using the DPPH (1,1-diphenyl-2-picryl-hydrazyl) free radical scavenging method.
Keywords:
1,4-dihidropiridini / estri / amidi / antioksidativna aktivnost / DPPH / slobodni radikaliSource:
Journal of Engineering & Processing Management, 2018, 10, 2, 8-15Publisher:
- University of East Sarajevo, Faculty of Technology
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Tehnološko-metalurški fakultetTY - JOUR AU - Mijatović, Tamara AU - Perić, Milica AU - Matović, Luka AU - Ristović, Marija AU - Drmanić, Saša PY - 2018 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3779 AB - Six ester and amide derivates of 2,6-dimethyl-4-(substituted)-1,4-dihydropyridine-3,5-dicarboxylic acid have been synthesized in this paper, including: diethyl 2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate, diethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, diethyl 2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, diethyl 4-(2-hydroxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, diethyl 4-(3-hydroxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate and diethyl 4-(4-hydroxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate. Obtained ester derivates were used afterwards as a starting compounds for synthesis of amide derivates, including: 2,6-dimethyl-4-phenyl-N3,N5-di(thiazol-2-yl)-1,4-dihydropyridine-3,5-dicarboxamide, 2,6-dimethyl-4-(3-nitrophenyl)-N3,N5-di(thiazol-2-yl)-1,4-dihydropyridine-3,5-dicarboxamide, 2,6-dimethyl-4-(4-nitrophenyl)-N3,N5-di(thiazol-2-yl)-1,4-dihydropyridine-3,5-dicarboxamide, 4-(2-hydroxyphenyl)-2,6-dimethyl-N3,N5-di(thiazol-2-yl)-1,4-dihydropyridine-3,5-dicarboxamide, 4-(3-hydroxyphenyl)-2,6-dimethyl-N3,N5-di(thiazol-2-yl)-1,4-dihydropyridine-3,5-dicarboxamide and 4-(4-hydroxyphenyl)-2,6-dimethyl-N3,N5-di(thiazol-2-yl)-1,4-dihydropyridine-3,5-dicarboxamide. Obtained compounds were characterized by melting point, elementary analysis and FT-IR spectroscopy. In order to determine the effect of the substituent, the antioxidative activity assay of obtained 1,4-dihydropyridines was performed by using the DPPH (1,1-diphenyl-2-picryl-hydrazyl) free radical scavenging method. PB - University of East Sarajevo, Faculty of Technology T2 - Journal of Engineering & Processing Management T1 - Sinteza, karakterizacija i ispitivanje antioksidativne aktivnosti estarskih i amidnih derivata 2,6-dimetil-4-supstituisane-1,4-dihidropiridin-3,5-dikarboksilne kiseline EP - 15 IS - 2 SP - 8 VL - 10 DO - 10.7251/JEPM181002008M ER -
@article{ author = "Mijatović, Tamara and Perić, Milica and Matović, Luka and Ristović, Marija and Drmanić, Saša", year = "2018", abstract = "Six ester and amide derivates of 2,6-dimethyl-4-(substituted)-1,4-dihydropyridine-3,5-dicarboxylic acid have been synthesized in this paper, including: diethyl 2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate, diethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, diethyl 2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, diethyl 4-(2-hydroxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, diethyl 4-(3-hydroxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate and diethyl 4-(4-hydroxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate. Obtained ester derivates were used afterwards as a starting compounds for synthesis of amide derivates, including: 2,6-dimethyl-4-phenyl-N3,N5-di(thiazol-2-yl)-1,4-dihydropyridine-3,5-dicarboxamide, 2,6-dimethyl-4-(3-nitrophenyl)-N3,N5-di(thiazol-2-yl)-1,4-dihydropyridine-3,5-dicarboxamide, 2,6-dimethyl-4-(4-nitrophenyl)-N3,N5-di(thiazol-2-yl)-1,4-dihydropyridine-3,5-dicarboxamide, 4-(2-hydroxyphenyl)-2,6-dimethyl-N3,N5-di(thiazol-2-yl)-1,4-dihydropyridine-3,5-dicarboxamide, 4-(3-hydroxyphenyl)-2,6-dimethyl-N3,N5-di(thiazol-2-yl)-1,4-dihydropyridine-3,5-dicarboxamide and 4-(4-hydroxyphenyl)-2,6-dimethyl-N3,N5-di(thiazol-2-yl)-1,4-dihydropyridine-3,5-dicarboxamide. Obtained compounds were characterized by melting point, elementary analysis and FT-IR spectroscopy. In order to determine the effect of the substituent, the antioxidative activity assay of obtained 1,4-dihydropyridines was performed by using the DPPH (1,1-diphenyl-2-picryl-hydrazyl) free radical scavenging method.", publisher = "University of East Sarajevo, Faculty of Technology", journal = "Journal of Engineering & Processing Management", title = "Sinteza, karakterizacija i ispitivanje antioksidativne aktivnosti estarskih i amidnih derivata 2,6-dimetil-4-supstituisane-1,4-dihidropiridin-3,5-dikarboksilne kiseline", pages = "15-8", number = "2", volume = "10", doi = "10.7251/JEPM181002008M" }
Mijatović, T., Perić, M., Matović, L., Ristović, M.,& Drmanić, S.. (2018). Sinteza, karakterizacija i ispitivanje antioksidativne aktivnosti estarskih i amidnih derivata 2,6-dimetil-4-supstituisane-1,4-dihidropiridin-3,5-dikarboksilne kiseline. in Journal of Engineering & Processing Management University of East Sarajevo, Faculty of Technology., 10(2), 8-15. https://doi.org/10.7251/JEPM181002008M
Mijatović T, Perić M, Matović L, Ristović M, Drmanić S. Sinteza, karakterizacija i ispitivanje antioksidativne aktivnosti estarskih i amidnih derivata 2,6-dimetil-4-supstituisane-1,4-dihidropiridin-3,5-dikarboksilne kiseline. in Journal of Engineering & Processing Management. 2018;10(2):8-15. doi:10.7251/JEPM181002008M .
Mijatović, Tamara, Perić, Milica, Matović, Luka, Ristović, Marija, Drmanić, Saša, "Sinteza, karakterizacija i ispitivanje antioksidativne aktivnosti estarskih i amidnih derivata 2,6-dimetil-4-supstituisane-1,4-dihidropiridin-3,5-dikarboksilne kiseline" in Journal of Engineering & Processing Management, 10, no. 2 (2018):8-15, https://doi.org/10.7251/JEPM181002008M . .