Achieving high antimicrobial activity: Composite alginate hydrogel beads releasing activated charcoal with an immobilized active agent
Authorized Users Only
2018
Authors
Osmokrović, AndreaJančić, Ivan
Vunduk, Jovana
Petrović, Predrag
Milenković, Marina
Obradović, Bojana
Article (Published version)
Metadata
Show full item recordAbstract
New composites based on Ca-alginate hydrogels were produced that release activated charcoal (AC) particles with adsorbed povidone iodine (PVP-I) as a model antimicrobial substance in a physiological-like environment. Composite beads with different alginate (0.5-1.5% w/w) and AC (1-20% w/w) concentrations were analyzed by FE-SEM and characterized regarding textural parameters, swelling, and AC release kinetics. PVP-I was easily adsorbed onto AC particles within the optimized beads (0.5% w/w alginate, 20% w/w AC) as indicated by UV-vis spectroscopy, EDX and FT-IR analyses. The obtained beads have shown strong bactericidal effects against two standard bacterial strains (Staphylococcus aureus and Pseudomonas aeruginosa) and clinical multi-resistant wound isolates (MRSA, Escherichia coli, Pseudomonas aeruginosa, Enterococcus faecalis and Proteus mirabilis) and, at the same time, exhibited negligible PVP-I desorption in physiological saline solution. Thus, the obtained composites could provi...de utilization of potent antiseptics such as iodine, in wound dressings, without the concern of systemic absorption.
Keywords:
Alginate / Activated charcoal / Povidone iodine / Antibacterial activity / Wound dressingSource:
Carbohydrate Polymers, 2018, 196, 279-288Publisher:
- Elsevier Sci Ltd, Oxford
Funding / projects:
- Synthesis, processing and applications of nanostructured multifunctional materials with defined properties (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45019)
DOI: 10.1016/j.carbpol.2018.05.045
ISSN: 0144-8617
PubMed: 29891298
WoS: 000436571600032
Scopus: 2-s2.0-85047260873
Collections
Institution/Community
Tehnološko-metalurški fakultetTY - JOUR AU - Osmokrović, Andrea AU - Jančić, Ivan AU - Vunduk, Jovana AU - Petrović, Predrag AU - Milenković, Marina AU - Obradović, Bojana PY - 2018 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3859 AB - New composites based on Ca-alginate hydrogels were produced that release activated charcoal (AC) particles with adsorbed povidone iodine (PVP-I) as a model antimicrobial substance in a physiological-like environment. Composite beads with different alginate (0.5-1.5% w/w) and AC (1-20% w/w) concentrations were analyzed by FE-SEM and characterized regarding textural parameters, swelling, and AC release kinetics. PVP-I was easily adsorbed onto AC particles within the optimized beads (0.5% w/w alginate, 20% w/w AC) as indicated by UV-vis spectroscopy, EDX and FT-IR analyses. The obtained beads have shown strong bactericidal effects against two standard bacterial strains (Staphylococcus aureus and Pseudomonas aeruginosa) and clinical multi-resistant wound isolates (MRSA, Escherichia coli, Pseudomonas aeruginosa, Enterococcus faecalis and Proteus mirabilis) and, at the same time, exhibited negligible PVP-I desorption in physiological saline solution. Thus, the obtained composites could provide utilization of potent antiseptics such as iodine, in wound dressings, without the concern of systemic absorption. PB - Elsevier Sci Ltd, Oxford T2 - Carbohydrate Polymers T1 - Achieving high antimicrobial activity: Composite alginate hydrogel beads releasing activated charcoal with an immobilized active agent EP - 288 SP - 279 VL - 196 DO - 10.1016/j.carbpol.2018.05.045 ER -
@article{ author = "Osmokrović, Andrea and Jančić, Ivan and Vunduk, Jovana and Petrović, Predrag and Milenković, Marina and Obradović, Bojana", year = "2018", abstract = "New composites based on Ca-alginate hydrogels were produced that release activated charcoal (AC) particles with adsorbed povidone iodine (PVP-I) as a model antimicrobial substance in a physiological-like environment. Composite beads with different alginate (0.5-1.5% w/w) and AC (1-20% w/w) concentrations were analyzed by FE-SEM and characterized regarding textural parameters, swelling, and AC release kinetics. PVP-I was easily adsorbed onto AC particles within the optimized beads (0.5% w/w alginate, 20% w/w AC) as indicated by UV-vis spectroscopy, EDX and FT-IR analyses. The obtained beads have shown strong bactericidal effects against two standard bacterial strains (Staphylococcus aureus and Pseudomonas aeruginosa) and clinical multi-resistant wound isolates (MRSA, Escherichia coli, Pseudomonas aeruginosa, Enterococcus faecalis and Proteus mirabilis) and, at the same time, exhibited negligible PVP-I desorption in physiological saline solution. Thus, the obtained composites could provide utilization of potent antiseptics such as iodine, in wound dressings, without the concern of systemic absorption.", publisher = "Elsevier Sci Ltd, Oxford", journal = "Carbohydrate Polymers", title = "Achieving high antimicrobial activity: Composite alginate hydrogel beads releasing activated charcoal with an immobilized active agent", pages = "288-279", volume = "196", doi = "10.1016/j.carbpol.2018.05.045" }
Osmokrović, A., Jančić, I., Vunduk, J., Petrović, P., Milenković, M.,& Obradović, B.. (2018). Achieving high antimicrobial activity: Composite alginate hydrogel beads releasing activated charcoal with an immobilized active agent. in Carbohydrate Polymers Elsevier Sci Ltd, Oxford., 196, 279-288. https://doi.org/10.1016/j.carbpol.2018.05.045
Osmokrović A, Jančić I, Vunduk J, Petrović P, Milenković M, Obradović B. Achieving high antimicrobial activity: Composite alginate hydrogel beads releasing activated charcoal with an immobilized active agent. in Carbohydrate Polymers. 2018;196:279-288. doi:10.1016/j.carbpol.2018.05.045 .
Osmokrović, Andrea, Jančić, Ivan, Vunduk, Jovana, Petrović, Predrag, Milenković, Marina, Obradović, Bojana, "Achieving high antimicrobial activity: Composite alginate hydrogel beads releasing activated charcoal with an immobilized active agent" in Carbohydrate Polymers, 196 (2018):279-288, https://doi.org/10.1016/j.carbpol.2018.05.045 . .
Related items
Showing items related by title, author, creator and subject.
-
Synthesis, antimicrobial activity and quantum chemical investigation of novel succinimide derivatives
Petković-Cvetković, Jelena; Božić, Bojan; Banjac, Nebojša; Petrović, Jovana; Soković, Marina; Vitnik, Vesna; Vitnik, Željko; Ušćumlić, Gordana; Valentić, Nataša (Elsevier Science Bv, Amsterdam, 2019) -
Preparation of biologically active polyphenols by utilising the primrose (Primula veris), the horsetail (Equisetum arvense) and the yarrow (Achillea millefolium) processing waste. / Iskoričćenje otpada iz prerade jagorčevine (Primula veris), rastavića (Equisetum arvense) i hajdučke trave (Achillea millefolium) za dobijanje biološki aktivnih polifenola
Milutinović, Milica (Univerzitet u Beogradu, Tehnološko-metalurški fakultet, 2017) -
Development of new antimicrobial bioactive composites for medical application in wound treatment / Razvoj novih antimkrobnih kompozita za medicinsku pripremu u terapiji rana
Osmokrović, Andrea (Univerzitet u Beogradu, Studije pri univerzitetu, 2018)