Added-value porous materials for controlled thymol release obtained by supercritical CO2 impregnation process
Само за регистроване кориснике
2019
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
This study explores utilization of biodegradable and biocompatible polymers for controlled release of natural bioactive substance. For that purpose, poly(epsilon-caprolactone) (PCL) beads, cellulose acetate (CA) film, and poly lactic-co-glycolic acid (PLGA) flakes were impregnated with thymol by employing environmentally friendly process of supercritical carbon dioxide (scCO(2)) impregnation. At selected pressure and temperature, prolongation of operating time increased thymol loading. Pure scCO(2) did not affect CA film with average pore diameter of approximately 3 mu m, while it enabled change of PCL beads and PLGA flakes into foams with average pore diameter approximately 175 mu m and 87 mu m, respectively. Additionally to scCO(2), thymol acted as a plasticizer increasing pore size of polymers up to three times. Kinetic of thymol release from selected samples was tested using phosphate buffer saline at 37 degrees C and successfully described with Korsmeyer-Peppas, zero-order, first-...order, and Higuchi models. The suggested method of PCL, CA, and PLGA supercritical impregnation led to development of porous, solvent free, added-value materials that release thymol in a controlled manner from 5 h to several days.
Кључне речи:
Cellulose acetate / poly(epsilon-caprolactone) / poly lactic-co-glycolic acid / thymol release kinetic / super-critical impregnationИзвор:
Cellular Polymers, 2019, 38, 5-6, 153-166Издавач:
- Sage Publications Ltd, London
Финансирање / пројекти:
- Функционални физиолошки активни биљни материјали са додатом вредношћу за примену у фармацеутској и прехрамбеној индустрији (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45017)
DOI: 10.1177/0262489319872329
ISSN: 0262-4893
WoS: 000489691200003
Scopus: 2-s2.0-85073007606
Колекције
Институција/група
Tehnološko-metalurški fakultetTY - JOUR AU - Milovanović, Stoja AU - Marković, Darka AU - Ivanović, Jasna PY - 2019 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4061 AB - This study explores utilization of biodegradable and biocompatible polymers for controlled release of natural bioactive substance. For that purpose, poly(epsilon-caprolactone) (PCL) beads, cellulose acetate (CA) film, and poly lactic-co-glycolic acid (PLGA) flakes were impregnated with thymol by employing environmentally friendly process of supercritical carbon dioxide (scCO(2)) impregnation. At selected pressure and temperature, prolongation of operating time increased thymol loading. Pure scCO(2) did not affect CA film with average pore diameter of approximately 3 mu m, while it enabled change of PCL beads and PLGA flakes into foams with average pore diameter approximately 175 mu m and 87 mu m, respectively. Additionally to scCO(2), thymol acted as a plasticizer increasing pore size of polymers up to three times. Kinetic of thymol release from selected samples was tested using phosphate buffer saline at 37 degrees C and successfully described with Korsmeyer-Peppas, zero-order, first-order, and Higuchi models. The suggested method of PCL, CA, and PLGA supercritical impregnation led to development of porous, solvent free, added-value materials that release thymol in a controlled manner from 5 h to several days. PB - Sage Publications Ltd, London T2 - Cellular Polymers T1 - Added-value porous materials for controlled thymol release obtained by supercritical CO2 impregnation process EP - 166 IS - 5-6 SP - 153 VL - 38 DO - 10.1177/0262489319872329 ER -
@article{ author = "Milovanović, Stoja and Marković, Darka and Ivanović, Jasna", year = "2019", abstract = "This study explores utilization of biodegradable and biocompatible polymers for controlled release of natural bioactive substance. For that purpose, poly(epsilon-caprolactone) (PCL) beads, cellulose acetate (CA) film, and poly lactic-co-glycolic acid (PLGA) flakes were impregnated with thymol by employing environmentally friendly process of supercritical carbon dioxide (scCO(2)) impregnation. At selected pressure and temperature, prolongation of operating time increased thymol loading. Pure scCO(2) did not affect CA film with average pore diameter of approximately 3 mu m, while it enabled change of PCL beads and PLGA flakes into foams with average pore diameter approximately 175 mu m and 87 mu m, respectively. Additionally to scCO(2), thymol acted as a plasticizer increasing pore size of polymers up to three times. Kinetic of thymol release from selected samples was tested using phosphate buffer saline at 37 degrees C and successfully described with Korsmeyer-Peppas, zero-order, first-order, and Higuchi models. The suggested method of PCL, CA, and PLGA supercritical impregnation led to development of porous, solvent free, added-value materials that release thymol in a controlled manner from 5 h to several days.", publisher = "Sage Publications Ltd, London", journal = "Cellular Polymers", title = "Added-value porous materials for controlled thymol release obtained by supercritical CO2 impregnation process", pages = "166-153", number = "5-6", volume = "38", doi = "10.1177/0262489319872329" }
Milovanović, S., Marković, D.,& Ivanović, J.. (2019). Added-value porous materials for controlled thymol release obtained by supercritical CO2 impregnation process. in Cellular Polymers Sage Publications Ltd, London., 38(5-6), 153-166. https://doi.org/10.1177/0262489319872329
Milovanović S, Marković D, Ivanović J. Added-value porous materials for controlled thymol release obtained by supercritical CO2 impregnation process. in Cellular Polymers. 2019;38(5-6):153-166. doi:10.1177/0262489319872329 .
Milovanović, Stoja, Marković, Darka, Ivanović, Jasna, "Added-value porous materials for controlled thymol release obtained by supercritical CO2 impregnation process" in Cellular Polymers, 38, no. 5-6 (2019):153-166, https://doi.org/10.1177/0262489319872329 . .