Immobilization of Chaga extract in alginate beads for modified release: simplicity meets efficiency
Imobilizacija ekstrakta čage u alginatne čestice u cilju modifikovanog oslobađanja: spoj jednostavnosti i efikasnosti
2019
Authors
Petrović, PredragIvanović, Katarina
Octrue, Charly
Tumara, Mica
Jovanović, Aleksandra
Vunduk, Jovana
Nikšić, Miomir
Pjanović, Rada
Bugarski, Branko
Klaus, Anita
Article (Published version)
Metadata
Show full item recordAbstract
Chaga (Inonotus obliquus) is a parasitic fungus, which has been used in traditional medicine in Russia and other northern European countries in the treatment of cancer, gastrointestinal andliver diseases. It has been a subject of intensive researchrecently, confirming many of its health-beneficial effects. In order to obtain a product that would allow modified and prolonged release of the Chaga's active metabolites, hot water Chaga extract was immobilized using calcium - alginate. The extract, which was predominantly composed of carbohydrates (57 %), also contained a relatively high amount of antioxidants/phenolic compounds (130 mg gallic acid equivalents per g of dry extract) and exhibited pronounced radical scavenging activity. It showed significant antibacterial activity as well, inhibiting growth of tested bacterial strains at concentrations of 1.25-20 mg/mL. Entrapment efficiency was about 80 %, and the extract-alginate system showed pH-dependant extract release; there was negligi...ble release at pH 1.75 (gastric pH), and the release gradually increased with the increase in pH, reaching similar to 43 % of immobilized extract at pH 8.5 after 90 min. Such a product could be used as a dietary supplement, adjuvant in therapy of gastrointestinal diseases or as a food additive.
Čaga (Inonotus obliquus) je parazitska gljiva koja se tradicionalno koristi u Rusiji i
drugim severnoevropskim zemljama u tretmanu raka, bolesti gastrointestinalnog
trakta i jetre, kao i drugih poremećaja. Poslednjih godina je predmet intenzivnog
proučavanja, koja su potvrdila mnoga blagotvorna dejstva čage na ljudski
organizam. Da bi se dobio proizvod koji bi omogućio modifikovano i produženo
oslobađanje aktivnih sastojaka čage, vreli vodeni ekstrakt ove gljive imobilisan je u
alginat kao nosač. Ekstrakt, koji se sastojao najviše od ugljenih hidrata (~57%),
sadržao je i veliku količinu antioksidantnih/fenolnih komponenti (130 mg
ekvivalenata galne kiseline po g suvog ekstrakta) i pokazao značajnu antiradikalsku
aktivnost. Ekstrakt je delovao i antibakterijski, inhibirajući rast testiranih sojeva pri
koncentracijama od 1.25-20 mg/mL. Efikasnost imobilizacijebila je oko 80%, a
sistem je pokazao pH-zavisno oslobađanje ekstrakta. Skoro da i nije bilo otpuštanja
komponenti ekst...rakta pri pH 1.75 (želudačna pH), dok je s porastom pH došlo i do
boljeg otpuštanja, koje je dostiglo maksimum od oko 43% oslobođenog ekstrakta
pri pH 8.5, nakon 90 min. Ovakav proizvod mogao bi da nađe primenu kao dijetetski
suplement, adjuvans u terapji gastrointestinalnih bolesti ili kao aditiv u hrani.
Keywords:
mushrooms / natural product / antioxidant / antimicrobial / encapsulation / gljive / prirodni proizvod / antioksidativno dejstvo / antimikrobno dejstvo / inkapsulacijaSource:
Hemijska industrija, 2019, 73, 5, 325-335Publisher:
- Savez hemijskih inženjera Srbije
Funding / projects:
- Novel encapsulation and enzyme technologies for designing of new biocatalysts and biologically active compounds targeting enhancement of food quality, safety and competitiveness (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-46010)
DOI: 10.2298/HEMIND190819028P
ISSN: 0367-598X
WoS: 000496945300005
Scopus: 2-s2.0-85075240386
Collections
Institution/Community
Tehnološko-metalurški fakultetTY - JOUR AU - Petrović, Predrag AU - Ivanović, Katarina AU - Octrue, Charly AU - Tumara, Mica AU - Jovanović, Aleksandra AU - Vunduk, Jovana AU - Nikšić, Miomir AU - Pjanović, Rada AU - Bugarski, Branko AU - Klaus, Anita PY - 2019 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4105 AB - Chaga (Inonotus obliquus) is a parasitic fungus, which has been used in traditional medicine in Russia and other northern European countries in the treatment of cancer, gastrointestinal andliver diseases. It has been a subject of intensive researchrecently, confirming many of its health-beneficial effects. In order to obtain a product that would allow modified and prolonged release of the Chaga's active metabolites, hot water Chaga extract was immobilized using calcium - alginate. The extract, which was predominantly composed of carbohydrates (57 %), also contained a relatively high amount of antioxidants/phenolic compounds (130 mg gallic acid equivalents per g of dry extract) and exhibited pronounced radical scavenging activity. It showed significant antibacterial activity as well, inhibiting growth of tested bacterial strains at concentrations of 1.25-20 mg/mL. Entrapment efficiency was about 80 %, and the extract-alginate system showed pH-dependant extract release; there was negligible release at pH 1.75 (gastric pH), and the release gradually increased with the increase in pH, reaching similar to 43 % of immobilized extract at pH 8.5 after 90 min. Such a product could be used as a dietary supplement, adjuvant in therapy of gastrointestinal diseases or as a food additive. AB - Čaga (Inonotus obliquus) je parazitska gljiva koja se tradicionalno koristi u Rusiji i drugim severnoevropskim zemljama u tretmanu raka, bolesti gastrointestinalnog trakta i jetre, kao i drugih poremećaja. Poslednjih godina je predmet intenzivnog proučavanja, koja su potvrdila mnoga blagotvorna dejstva čage na ljudski organizam. Da bi se dobio proizvod koji bi omogućio modifikovano i produženo oslobađanje aktivnih sastojaka čage, vreli vodeni ekstrakt ove gljive imobilisan je u alginat kao nosač. Ekstrakt, koji se sastojao najviše od ugljenih hidrata (~57%), sadržao je i veliku količinu antioksidantnih/fenolnih komponenti (130 mg ekvivalenata galne kiseline po g suvog ekstrakta) i pokazao značajnu antiradikalsku aktivnost. Ekstrakt je delovao i antibakterijski, inhibirajući rast testiranih sojeva pri koncentracijama od 1.25-20 mg/mL. Efikasnost imobilizacijebila je oko 80%, a sistem je pokazao pH-zavisno oslobađanje ekstrakta. Skoro da i nije bilo otpuštanja komponenti ekstrakta pri pH 1.75 (želudačna pH), dok je s porastom pH došlo i do boljeg otpuštanja, koje je dostiglo maksimum od oko 43% oslobođenog ekstrakta pri pH 8.5, nakon 90 min. Ovakav proizvod mogao bi da nađe primenu kao dijetetski suplement, adjuvans u terapji gastrointestinalnih bolesti ili kao aditiv u hrani. PB - Savez hemijskih inženjera Srbije T2 - Hemijska industrija T1 - Immobilization of Chaga extract in alginate beads for modified release: simplicity meets efficiency T1 - Imobilizacija ekstrakta čage u alginatne čestice u cilju modifikovanog oslobađanja: spoj jednostavnosti i efikasnosti EP - 335 IS - 5 SP - 325 VL - 73 DO - 10.2298/HEMIND190819028P ER -
@article{ author = "Petrović, Predrag and Ivanović, Katarina and Octrue, Charly and Tumara, Mica and Jovanović, Aleksandra and Vunduk, Jovana and Nikšić, Miomir and Pjanović, Rada and Bugarski, Branko and Klaus, Anita", year = "2019", abstract = "Chaga (Inonotus obliquus) is a parasitic fungus, which has been used in traditional medicine in Russia and other northern European countries in the treatment of cancer, gastrointestinal andliver diseases. It has been a subject of intensive researchrecently, confirming many of its health-beneficial effects. In order to obtain a product that would allow modified and prolonged release of the Chaga's active metabolites, hot water Chaga extract was immobilized using calcium - alginate. The extract, which was predominantly composed of carbohydrates (57 %), also contained a relatively high amount of antioxidants/phenolic compounds (130 mg gallic acid equivalents per g of dry extract) and exhibited pronounced radical scavenging activity. It showed significant antibacterial activity as well, inhibiting growth of tested bacterial strains at concentrations of 1.25-20 mg/mL. Entrapment efficiency was about 80 %, and the extract-alginate system showed pH-dependant extract release; there was negligible release at pH 1.75 (gastric pH), and the release gradually increased with the increase in pH, reaching similar to 43 % of immobilized extract at pH 8.5 after 90 min. Such a product could be used as a dietary supplement, adjuvant in therapy of gastrointestinal diseases or as a food additive., Čaga (Inonotus obliquus) je parazitska gljiva koja se tradicionalno koristi u Rusiji i drugim severnoevropskim zemljama u tretmanu raka, bolesti gastrointestinalnog trakta i jetre, kao i drugih poremećaja. Poslednjih godina je predmet intenzivnog proučavanja, koja su potvrdila mnoga blagotvorna dejstva čage na ljudski organizam. Da bi se dobio proizvod koji bi omogućio modifikovano i produženo oslobađanje aktivnih sastojaka čage, vreli vodeni ekstrakt ove gljive imobilisan je u alginat kao nosač. Ekstrakt, koji se sastojao najviše od ugljenih hidrata (~57%), sadržao je i veliku količinu antioksidantnih/fenolnih komponenti (130 mg ekvivalenata galne kiseline po g suvog ekstrakta) i pokazao značajnu antiradikalsku aktivnost. Ekstrakt je delovao i antibakterijski, inhibirajući rast testiranih sojeva pri koncentracijama od 1.25-20 mg/mL. Efikasnost imobilizacijebila je oko 80%, a sistem je pokazao pH-zavisno oslobađanje ekstrakta. Skoro da i nije bilo otpuštanja komponenti ekstrakta pri pH 1.75 (želudačna pH), dok je s porastom pH došlo i do boljeg otpuštanja, koje je dostiglo maksimum od oko 43% oslobođenog ekstrakta pri pH 8.5, nakon 90 min. Ovakav proizvod mogao bi da nađe primenu kao dijetetski suplement, adjuvans u terapji gastrointestinalnih bolesti ili kao aditiv u hrani.", publisher = "Savez hemijskih inženjera Srbije", journal = "Hemijska industrija", title = "Immobilization of Chaga extract in alginate beads for modified release: simplicity meets efficiency, Imobilizacija ekstrakta čage u alginatne čestice u cilju modifikovanog oslobađanja: spoj jednostavnosti i efikasnosti", pages = "335-325", number = "5", volume = "73", doi = "10.2298/HEMIND190819028P" }
Petrović, P., Ivanović, K., Octrue, C., Tumara, M., Jovanović, A., Vunduk, J., Nikšić, M., Pjanović, R., Bugarski, B.,& Klaus, A.. (2019). Immobilization of Chaga extract in alginate beads for modified release: simplicity meets efficiency. in Hemijska industrija Savez hemijskih inženjera Srbije., 73(5), 325-335. https://doi.org/10.2298/HEMIND190819028P
Petrović P, Ivanović K, Octrue C, Tumara M, Jovanović A, Vunduk J, Nikšić M, Pjanović R, Bugarski B, Klaus A. Immobilization of Chaga extract in alginate beads for modified release: simplicity meets efficiency. in Hemijska industrija. 2019;73(5):325-335. doi:10.2298/HEMIND190819028P .
Petrović, Predrag, Ivanović, Katarina, Octrue, Charly, Tumara, Mica, Jovanović, Aleksandra, Vunduk, Jovana, Nikšić, Miomir, Pjanović, Rada, Bugarski, Branko, Klaus, Anita, "Immobilization of Chaga extract in alginate beads for modified release: simplicity meets efficiency" in Hemijska industrija, 73, no. 5 (2019):325-335, https://doi.org/10.2298/HEMIND190819028P . .