Functionalized Periodic Mesoporous Organosilica Nanoparticles for Loading and Delivery of Suramin
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Suramin (SUR) is a known drug for treating parasitic infections though research studies and some clinical trials have shown its applicability for a plethora of other diseases. Herein we report on a novel SUR nanocarrier for the drug delivery to cells. We synthesized periodic mesoporous organosilica nanoparticles with spherical morphology, having mean diameter of 240 nm and high surface area (778 m(2)/g). The material's surface is modified with an amine-containing organic moiety N-[3-(Trimethoxysilyl)propyl]ethylenediamine (DA), followed by surface attachment with the drug. The rate of SUR release in physiological condition was low, though in vitro experiments on MRC-5 cell line demonstrate effective delivery of the drug to the cells and low toxicity of the materials without the adsorbed drug. These results are promising for opening new treatment strategies with SUR-bearing nanocarriers, with high efficiency and low adverse effects on healthy tissues.
Кључне речи:
drug delivery / nanocarrier / porous nanoparticles / cancer treatmentИзвор:
Inorganics, 2019, 7, 2Издавач:
- MDPI, Basel
Финансирање / пројекти:
- Синтеза, развој технологија добијања и примена наноструктурних мултифункционалних материјала дефинисаних својстава (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45019)
- Развој нових информационо-комуникационих технологија, коришћењем напредних математичких метода, са применама у медицини, телекомуникацијама, енергетици, заштитити националне баштине и образовању (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-44006)
DOI: 10.3390/inorganics7020016
ISSN: 2304-6740
WoS: 000460321800010
Scopus: 2-s2.0-85062146124
Институција/група
Tehnološko-metalurški fakultetTY - JOUR AU - Knežević, Nikola Ž. AU - Đorđević, Sanja AU - Kojić, Vesna AU - Janaćković, Đorđe PY - 2019 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4156 AB - Suramin (SUR) is a known drug for treating parasitic infections though research studies and some clinical trials have shown its applicability for a plethora of other diseases. Herein we report on a novel SUR nanocarrier for the drug delivery to cells. We synthesized periodic mesoporous organosilica nanoparticles with spherical morphology, having mean diameter of 240 nm and high surface area (778 m(2)/g). The material's surface is modified with an amine-containing organic moiety N-[3-(Trimethoxysilyl)propyl]ethylenediamine (DA), followed by surface attachment with the drug. The rate of SUR release in physiological condition was low, though in vitro experiments on MRC-5 cell line demonstrate effective delivery of the drug to the cells and low toxicity of the materials without the adsorbed drug. These results are promising for opening new treatment strategies with SUR-bearing nanocarriers, with high efficiency and low adverse effects on healthy tissues. PB - MDPI, Basel T2 - Inorganics T1 - Functionalized Periodic Mesoporous Organosilica Nanoparticles for Loading and Delivery of Suramin IS - 2 VL - 7 DO - 10.3390/inorganics7020016 ER -
@article{ author = "Knežević, Nikola Ž. and Đorđević, Sanja and Kojić, Vesna and Janaćković, Đorđe", year = "2019", abstract = "Suramin (SUR) is a known drug for treating parasitic infections though research studies and some clinical trials have shown its applicability for a plethora of other diseases. Herein we report on a novel SUR nanocarrier for the drug delivery to cells. We synthesized periodic mesoporous organosilica nanoparticles with spherical morphology, having mean diameter of 240 nm and high surface area (778 m(2)/g). The material's surface is modified with an amine-containing organic moiety N-[3-(Trimethoxysilyl)propyl]ethylenediamine (DA), followed by surface attachment with the drug. The rate of SUR release in physiological condition was low, though in vitro experiments on MRC-5 cell line demonstrate effective delivery of the drug to the cells and low toxicity of the materials without the adsorbed drug. These results are promising for opening new treatment strategies with SUR-bearing nanocarriers, with high efficiency and low adverse effects on healthy tissues.", publisher = "MDPI, Basel", journal = "Inorganics", title = "Functionalized Periodic Mesoporous Organosilica Nanoparticles for Loading and Delivery of Suramin", number = "2", volume = "7", doi = "10.3390/inorganics7020016" }
Knežević, N. Ž., Đorđević, S., Kojić, V.,& Janaćković, Đ.. (2019). Functionalized Periodic Mesoporous Organosilica Nanoparticles for Loading and Delivery of Suramin. in Inorganics MDPI, Basel., 7(2). https://doi.org/10.3390/inorganics7020016
Knežević NŽ, Đorđević S, Kojić V, Janaćković Đ. Functionalized Periodic Mesoporous Organosilica Nanoparticles for Loading and Delivery of Suramin. in Inorganics. 2019;7(2). doi:10.3390/inorganics7020016 .
Knežević, Nikola Ž., Đorđević, Sanja, Kojić, Vesna, Janaćković, Đorđe, "Functionalized Periodic Mesoporous Organosilica Nanoparticles for Loading and Delivery of Suramin" in Inorganics, 7, no. 2 (2019), https://doi.org/10.3390/inorganics7020016 . .