Novel Approach for Flavonoid Esters Production: Statistically Optimized Enzymatic Synthesis Using Natural Oils and Application in Cosmetics
Само за регистроване кориснике
2019
Аутори
Milivojević, AnaĆorović, Marija
Simović, Milica
Banjanac, Katarina
Blagojević, Stevan N.
Pjanović, Rada
Bezbradica, Dejan
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The present work describes application of natural triglycerides for lipase-catalyzed esterification of structurally diverse flavonoids-esculin, naringin, and phloridzin. Ester mixtures with laurate, linolenate, or linoleate as prevailing products were obtained in reactions with coconut, linseed, and sunflower oils, respectively. By using response surface methodology, the influences of key experimental factors-reaction time, substrates, and enzyme concentrations-for transesterification of esculin with linseed oil were investigated. High molar conversion (78.5%), product yield (19.13 mg/mL), and specific yield (2.83 mmol/g(enzyme)) were achieved at optimized conditions. Determined optimums were successfully applied in esculin transesterification with other two oils. Furthermore, esculin ester mixtures were incorporated in gel emulsions, and their effect on transepidermal water loss (TEWL) as well as skin sensitivity was examined. Obtained results have shown significant hydration effect a...nd good dermatological compatibility without irritating effects of all examined preparations containing oil-derived esculin esters, making them very prospective for application in skin care products.
Извор:
Industrial & Engineering Chemistry Research, 2019, 58, 9, 3640-3649Издавач:
- Amer Chemical Soc, Washington
Финансирање / пројекти:
- Serbian Ministry of Education, Science and Technological Development
- Примена биотехнолошких метода у одрживом искоришћењу нус-производа агроиндустрије (RS-MESTD-Technological Development (TD or TR)-31035)
- Развој нових инкапсулационих и ензимских технологија за производњу биокатализатора и биолошки активних компонената хране у циљу повећања њене конкурентности, квалитета и безбедности (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-46010)
- Динамика нелинеарних физичкохемијских и биохемијских система са моделирањем и предвиђањем њихових понашања под неравнотежним условима (RS-MESTD-Basic Research (BR or ON)-172015)
DOI: 10.1021/acs.iecr.8b06113
ISSN: 0888-5885
WoS: 000460996700008
Scopus: 2-s2.0-85062593345
Колекције
Институција/група
Tehnološko-metalurški fakultetTY - JOUR AU - Milivojević, Ana AU - Ćorović, Marija AU - Simović, Milica AU - Banjanac, Katarina AU - Blagojević, Stevan N. AU - Pjanović, Rada AU - Bezbradica, Dejan PY - 2019 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4158 AB - The present work describes application of natural triglycerides for lipase-catalyzed esterification of structurally diverse flavonoids-esculin, naringin, and phloridzin. Ester mixtures with laurate, linolenate, or linoleate as prevailing products were obtained in reactions with coconut, linseed, and sunflower oils, respectively. By using response surface methodology, the influences of key experimental factors-reaction time, substrates, and enzyme concentrations-for transesterification of esculin with linseed oil were investigated. High molar conversion (78.5%), product yield (19.13 mg/mL), and specific yield (2.83 mmol/g(enzyme)) were achieved at optimized conditions. Determined optimums were successfully applied in esculin transesterification with other two oils. Furthermore, esculin ester mixtures were incorporated in gel emulsions, and their effect on transepidermal water loss (TEWL) as well as skin sensitivity was examined. Obtained results have shown significant hydration effect and good dermatological compatibility without irritating effects of all examined preparations containing oil-derived esculin esters, making them very prospective for application in skin care products. PB - Amer Chemical Soc, Washington T2 - Industrial & Engineering Chemistry Research T1 - Novel Approach for Flavonoid Esters Production: Statistically Optimized Enzymatic Synthesis Using Natural Oils and Application in Cosmetics EP - 3649 IS - 9 SP - 3640 VL - 58 DO - 10.1021/acs.iecr.8b06113 ER -
@article{ author = "Milivojević, Ana and Ćorović, Marija and Simović, Milica and Banjanac, Katarina and Blagojević, Stevan N. and Pjanović, Rada and Bezbradica, Dejan", year = "2019", abstract = "The present work describes application of natural triglycerides for lipase-catalyzed esterification of structurally diverse flavonoids-esculin, naringin, and phloridzin. Ester mixtures with laurate, linolenate, or linoleate as prevailing products were obtained in reactions with coconut, linseed, and sunflower oils, respectively. By using response surface methodology, the influences of key experimental factors-reaction time, substrates, and enzyme concentrations-for transesterification of esculin with linseed oil were investigated. High molar conversion (78.5%), product yield (19.13 mg/mL), and specific yield (2.83 mmol/g(enzyme)) were achieved at optimized conditions. Determined optimums were successfully applied in esculin transesterification with other two oils. Furthermore, esculin ester mixtures were incorporated in gel emulsions, and their effect on transepidermal water loss (TEWL) as well as skin sensitivity was examined. Obtained results have shown significant hydration effect and good dermatological compatibility without irritating effects of all examined preparations containing oil-derived esculin esters, making them very prospective for application in skin care products.", publisher = "Amer Chemical Soc, Washington", journal = "Industrial & Engineering Chemistry Research", title = "Novel Approach for Flavonoid Esters Production: Statistically Optimized Enzymatic Synthesis Using Natural Oils and Application in Cosmetics", pages = "3649-3640", number = "9", volume = "58", doi = "10.1021/acs.iecr.8b06113" }
Milivojević, A., Ćorović, M., Simović, M., Banjanac, K., Blagojević, S. N., Pjanović, R.,& Bezbradica, D.. (2019). Novel Approach for Flavonoid Esters Production: Statistically Optimized Enzymatic Synthesis Using Natural Oils and Application in Cosmetics. in Industrial & Engineering Chemistry Research Amer Chemical Soc, Washington., 58(9), 3640-3649. https://doi.org/10.1021/acs.iecr.8b06113
Milivojević A, Ćorović M, Simović M, Banjanac K, Blagojević SN, Pjanović R, Bezbradica D. Novel Approach for Flavonoid Esters Production: Statistically Optimized Enzymatic Synthesis Using Natural Oils and Application in Cosmetics. in Industrial & Engineering Chemistry Research. 2019;58(9):3640-3649. doi:10.1021/acs.iecr.8b06113 .
Milivojević, Ana, Ćorović, Marija, Simović, Milica, Banjanac, Katarina, Blagojević, Stevan N., Pjanović, Rada, Bezbradica, Dejan, "Novel Approach for Flavonoid Esters Production: Statistically Optimized Enzymatic Synthesis Using Natural Oils and Application in Cosmetics" in Industrial & Engineering Chemistry Research, 58, no. 9 (2019):3640-3649, https://doi.org/10.1021/acs.iecr.8b06113 . .