Effect of composition and method of preparation of 2-hydroxyethyl methacrylate/gelatin hydrogels on biological in vitro (cell line) and in vivo (zebrafish) properties
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2020
Authors
Tomić, SimonidaBabić, Marija
Vuković, Jovana
Đokić, Lidija
Pavić, Aleksandar
Nikodinović-Runić, Jasmina
Article (Published version)
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We have studied the effect of compositions and methods of preparation on the physico-chemical and biocompatible behavior of the hydrogel matrices. Hydrogel matrices are synthesized by free radical polymerization of 2-hydroxyethyl methacrylate net and with gelatin. Highly porous hydrogel structures were obtained by porogenation, and by cryogenic treatment followed by freeze-drying. All samples were characterized for structural, morphological, absorption, degradation and in vitro (healthy human fibroblast cell line) and in vivo (zebrafishDanio rerio) biocompatible properties. The obtained results show that cryo samples, especially with gelatin show better, favorable absorption, morphological and biocompatible properties in comparison with PHEMA samples, which makes these materials highly attractive for biomedical uses.
Keywords:
2-Hydroxyethyl methacrylate / Gelatin / Hydrogel / Morphology / Absorption / Biocompatible in vitro and in vivo propertiesSource:
Journal of Polymer Research, 2020, 27, 10, 305-Publisher:
- Springer, Dordrecht
Funding / projects:
- SCOPES program of the Swiss National Science Foundation (SNSF)Swiss National Science Foundation (SNSF)
- Swiss Agency for Development and Cooperation (SDC) [IZ73ZO_152327]
- Synthesis and characterization of novel functional polymers and polymeric nanocomposites (RS-MESTD-Basic Research (BR or ON)-172062)
- Chemical and structural designing of nanomaterials for application in medicine and tissue engineering (RS-MESTD-Basic Research (BR or ON)-172026)
DOI: 10.1007/s10965-020-02219-w
ISSN: 1022-9760
WoS: 000574616600002
Scopus: 2-s2.0-85091318852
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Tehnološko-metalurški fakultetTY - JOUR AU - Tomić, Simonida AU - Babić, Marija AU - Vuković, Jovana AU - Đokić, Lidija AU - Pavić, Aleksandar AU - Nikodinović-Runić, Jasmina PY - 2020 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4379 AB - We have studied the effect of compositions and methods of preparation on the physico-chemical and biocompatible behavior of the hydrogel matrices. Hydrogel matrices are synthesized by free radical polymerization of 2-hydroxyethyl methacrylate net and with gelatin. Highly porous hydrogel structures were obtained by porogenation, and by cryogenic treatment followed by freeze-drying. All samples were characterized for structural, morphological, absorption, degradation and in vitro (healthy human fibroblast cell line) and in vivo (zebrafishDanio rerio) biocompatible properties. The obtained results show that cryo samples, especially with gelatin show better, favorable absorption, morphological and biocompatible properties in comparison with PHEMA samples, which makes these materials highly attractive for biomedical uses. PB - Springer, Dordrecht T2 - Journal of Polymer Research T1 - Effect of composition and method of preparation of 2-hydroxyethyl methacrylate/gelatin hydrogels on biological in vitro (cell line) and in vivo (zebrafish) properties IS - 10 SP - 305 VL - 27 DO - 10.1007/s10965-020-02219-w ER -
@article{ author = "Tomić, Simonida and Babić, Marija and Vuković, Jovana and Đokić, Lidija and Pavić, Aleksandar and Nikodinović-Runić, Jasmina", year = "2020", abstract = "We have studied the effect of compositions and methods of preparation on the physico-chemical and biocompatible behavior of the hydrogel matrices. Hydrogel matrices are synthesized by free radical polymerization of 2-hydroxyethyl methacrylate net and with gelatin. Highly porous hydrogel structures were obtained by porogenation, and by cryogenic treatment followed by freeze-drying. All samples were characterized for structural, morphological, absorption, degradation and in vitro (healthy human fibroblast cell line) and in vivo (zebrafishDanio rerio) biocompatible properties. The obtained results show that cryo samples, especially with gelatin show better, favorable absorption, morphological and biocompatible properties in comparison with PHEMA samples, which makes these materials highly attractive for biomedical uses.", publisher = "Springer, Dordrecht", journal = "Journal of Polymer Research", title = "Effect of composition and method of preparation of 2-hydroxyethyl methacrylate/gelatin hydrogels on biological in vitro (cell line) and in vivo (zebrafish) properties", number = "10", pages = "305", volume = "27", doi = "10.1007/s10965-020-02219-w" }
Tomić, S., Babić, M., Vuković, J., Đokić, L., Pavić, A.,& Nikodinović-Runić, J.. (2020). Effect of composition and method of preparation of 2-hydroxyethyl methacrylate/gelatin hydrogels on biological in vitro (cell line) and in vivo (zebrafish) properties. in Journal of Polymer Research Springer, Dordrecht., 27(10), 305. https://doi.org/10.1007/s10965-020-02219-w
Tomić S, Babić M, Vuković J, Đokić L, Pavić A, Nikodinović-Runić J. Effect of composition and method of preparation of 2-hydroxyethyl methacrylate/gelatin hydrogels on biological in vitro (cell line) and in vivo (zebrafish) properties. in Journal of Polymer Research. 2020;27(10):305. doi:10.1007/s10965-020-02219-w .
Tomić, Simonida, Babić, Marija, Vuković, Jovana, Đokić, Lidija, Pavić, Aleksandar, Nikodinović-Runić, Jasmina, "Effect of composition and method of preparation of 2-hydroxyethyl methacrylate/gelatin hydrogels on biological in vitro (cell line) and in vivo (zebrafish) properties" in Journal of Polymer Research, 27, no. 10 (2020):305, https://doi.org/10.1007/s10965-020-02219-w . .