Collective cell migration and residual stress accumulation: Rheological consideration
Abstract
Stress generation during collective cell migration represents one of the key factors which influence the configuration of migrating cells, viscoelasticity of multicellular systems and their inter-relation. Local generation of stress (normal and shear) is significant even in 2D. Normal stress is primarily accumulated within a core region of migrating cell clusters during their movement through the dense environment and during the collisions of migrating cell clusters caused by uncorrelated motility. Shear stress can be significant within perturbed boundary layers around migrating clusters. Cells are more sensitive to the action of shear stress compared with normal stress. Shear stress of a few Pa significantly influences cell state. Prior studies have shown that collectively migrating cells move in such a way to minimize this stress, but it has not yet been determined how cells effectively minimize it. Deeper insight into possible cell mechanisms for minimizing undesirable shear stress ...would be of great importance because it may help to direct morphogenesis, accelerate wound healing or prevent cancer invasion. In the proposed model three primary mechanisms in which cells may reduce shear are given: decreasing speed, tissue thickening, and/or reducing slip effects. Suggestions obtained from the proposed model indicate a need for further experimental studies that will reveal whether the heterogeneity in the cell-cell adhesion types correlates well with the stiffness inhomogeneity, or changes in the adhesion clustering, cytoskeletal linkage or some other modification to the adhesion complex (adherens junctions or tight junctions) are occurring to influence overall adhesive strength.
Keywords:
Viscoelasticity / Collective cell migration / Residual stress accumulation / Stiffness inhomogeneity / Slip effectsSource:
Journal of Biomechanics, 2020, 108Publisher:
- Elsevier Sci Ltd, Oxford
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200135 (University of Belgrade, Faculty of Technology and Metallurgy) (RS-MESTD-inst-2020-200135)
DOI: 10.1016/j.jbiomech.2020.109898
ISSN: 0021-9290
PubMed: 32636009
WoS: 000546647000020
Scopus: 2-s2.0-85086579361
Institution/Community
Tehnološko-metalurški fakultetTY - JOUR AU - Pajić-Lijaković, Ivana AU - Milivojević, Milan PY - 2020 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4511 AB - Stress generation during collective cell migration represents one of the key factors which influence the configuration of migrating cells, viscoelasticity of multicellular systems and their inter-relation. Local generation of stress (normal and shear) is significant even in 2D. Normal stress is primarily accumulated within a core region of migrating cell clusters during their movement through the dense environment and during the collisions of migrating cell clusters caused by uncorrelated motility. Shear stress can be significant within perturbed boundary layers around migrating clusters. Cells are more sensitive to the action of shear stress compared with normal stress. Shear stress of a few Pa significantly influences cell state. Prior studies have shown that collectively migrating cells move in such a way to minimize this stress, but it has not yet been determined how cells effectively minimize it. Deeper insight into possible cell mechanisms for minimizing undesirable shear stress would be of great importance because it may help to direct morphogenesis, accelerate wound healing or prevent cancer invasion. In the proposed model three primary mechanisms in which cells may reduce shear are given: decreasing speed, tissue thickening, and/or reducing slip effects. Suggestions obtained from the proposed model indicate a need for further experimental studies that will reveal whether the heterogeneity in the cell-cell adhesion types correlates well with the stiffness inhomogeneity, or changes in the adhesion clustering, cytoskeletal linkage or some other modification to the adhesion complex (adherens junctions or tight junctions) are occurring to influence overall adhesive strength. PB - Elsevier Sci Ltd, Oxford T2 - Journal of Biomechanics T1 - Collective cell migration and residual stress accumulation: Rheological consideration VL - 108 DO - 10.1016/j.jbiomech.2020.109898 ER -
@article{ author = "Pajić-Lijaković, Ivana and Milivojević, Milan", year = "2020", abstract = "Stress generation during collective cell migration represents one of the key factors which influence the configuration of migrating cells, viscoelasticity of multicellular systems and their inter-relation. Local generation of stress (normal and shear) is significant even in 2D. Normal stress is primarily accumulated within a core region of migrating cell clusters during their movement through the dense environment and during the collisions of migrating cell clusters caused by uncorrelated motility. Shear stress can be significant within perturbed boundary layers around migrating clusters. Cells are more sensitive to the action of shear stress compared with normal stress. Shear stress of a few Pa significantly influences cell state. Prior studies have shown that collectively migrating cells move in such a way to minimize this stress, but it has not yet been determined how cells effectively minimize it. Deeper insight into possible cell mechanisms for minimizing undesirable shear stress would be of great importance because it may help to direct morphogenesis, accelerate wound healing or prevent cancer invasion. In the proposed model three primary mechanisms in which cells may reduce shear are given: decreasing speed, tissue thickening, and/or reducing slip effects. Suggestions obtained from the proposed model indicate a need for further experimental studies that will reveal whether the heterogeneity in the cell-cell adhesion types correlates well with the stiffness inhomogeneity, or changes in the adhesion clustering, cytoskeletal linkage or some other modification to the adhesion complex (adherens junctions or tight junctions) are occurring to influence overall adhesive strength.", publisher = "Elsevier Sci Ltd, Oxford", journal = "Journal of Biomechanics", title = "Collective cell migration and residual stress accumulation: Rheological consideration", volume = "108", doi = "10.1016/j.jbiomech.2020.109898" }
Pajić-Lijaković, I.,& Milivojević, M.. (2020). Collective cell migration and residual stress accumulation: Rheological consideration. in Journal of Biomechanics Elsevier Sci Ltd, Oxford., 108. https://doi.org/10.1016/j.jbiomech.2020.109898
Pajić-Lijaković I, Milivojević M. Collective cell migration and residual stress accumulation: Rheological consideration. in Journal of Biomechanics. 2020;108. doi:10.1016/j.jbiomech.2020.109898 .
Pajić-Lijaković, Ivana, Milivojević, Milan, "Collective cell migration and residual stress accumulation: Rheological consideration" in Journal of Biomechanics, 108 (2020), https://doi.org/10.1016/j.jbiomech.2020.109898 . .