Mucoadhesive Gelatin Buccal Films with Propranolol Hydrochloride: Evaluation of Mechanical, Mucoadhesive, and Biopharmaceutical Properties
2021
Аутори
Jovanović, MarijaTomić, Nataša
Cvijic, Sandra
Stojanović, Dušica
Ibric, Svetlana
Uskoković, Petar
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
This study processes and characterizes propranolol hydrochloride/gelatin mucoadhesive buccal films. Two types of gelatin are used: Gelatin from porcine skin, type A (GA), and gelatin from bovine skin (GB). The influence of gelatin type on mechanical, mucoadhesive, and biopharmaceutical characteristics of buccal films is evaluated. Fourier-Transfer infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) analysis show that GA with propranolol hydrochloride (PRH) in the film (GAP) formed a physical mixture, whereas GB with PRH (GBP) form a compound-complex. Results of mechanical testing (tensile test, hardness) revealed that GAP films exhibit higher elastic modulus, tensile strength, and hardness. A mucoahesion test shows that GBP has higher adhesion strength, while GAP shows higher work of adhesion. Both in vitro release study and in silico simulation indicated that processed films can provide effective drug transport through the buccal mucosa. In silico simulation shows... improved bioavailability from buccal films, in comparison to the immediate-release tablets-indicating that the therapeutic drug dose can be markedly reduced.
Кључне речи:
mucoadhesion / buccal films / gelatin / propranolol hydrochloride / in silico simulationИзвор:
Pharmaceutics, 2021, 13, 2Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200135 (Универзитет у Београду, Технолошко-металуршки факултет) (RS-MESTD-inst-2020-200135)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200161 (Универзитет у Београду, Фармацеутски факултет) (RS-MESTD-inst-2020-200161)
DOI: 10.3390/pharmaceutics13020273
ISSN: 1999-4923
PubMed: 33670448
WoS: 000622989500001
Scopus: 2-s2.0-85101880557
Колекције
Институција/група
Tehnološko-metalurški fakultetTY - JOUR AU - Jovanović, Marija AU - Tomić, Nataša AU - Cvijic, Sandra AU - Stojanović, Dušica AU - Ibric, Svetlana AU - Uskoković, Petar PY - 2021 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4909 AB - This study processes and characterizes propranolol hydrochloride/gelatin mucoadhesive buccal films. Two types of gelatin are used: Gelatin from porcine skin, type A (GA), and gelatin from bovine skin (GB). The influence of gelatin type on mechanical, mucoadhesive, and biopharmaceutical characteristics of buccal films is evaluated. Fourier-Transfer infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) analysis show that GA with propranolol hydrochloride (PRH) in the film (GAP) formed a physical mixture, whereas GB with PRH (GBP) form a compound-complex. Results of mechanical testing (tensile test, hardness) revealed that GAP films exhibit higher elastic modulus, tensile strength, and hardness. A mucoahesion test shows that GBP has higher adhesion strength, while GAP shows higher work of adhesion. Both in vitro release study and in silico simulation indicated that processed films can provide effective drug transport through the buccal mucosa. In silico simulation shows improved bioavailability from buccal films, in comparison to the immediate-release tablets-indicating that the therapeutic drug dose can be markedly reduced. T2 - Pharmaceutics T1 - Mucoadhesive Gelatin Buccal Films with Propranolol Hydrochloride: Evaluation of Mechanical, Mucoadhesive, and Biopharmaceutical Properties IS - 2 VL - 13 DO - 10.3390/pharmaceutics13020273 ER -
@article{ author = "Jovanović, Marija and Tomić, Nataša and Cvijic, Sandra and Stojanović, Dušica and Ibric, Svetlana and Uskoković, Petar", year = "2021", abstract = "This study processes and characterizes propranolol hydrochloride/gelatin mucoadhesive buccal films. Two types of gelatin are used: Gelatin from porcine skin, type A (GA), and gelatin from bovine skin (GB). The influence of gelatin type on mechanical, mucoadhesive, and biopharmaceutical characteristics of buccal films is evaluated. Fourier-Transfer infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) analysis show that GA with propranolol hydrochloride (PRH) in the film (GAP) formed a physical mixture, whereas GB with PRH (GBP) form a compound-complex. Results of mechanical testing (tensile test, hardness) revealed that GAP films exhibit higher elastic modulus, tensile strength, and hardness. A mucoahesion test shows that GBP has higher adhesion strength, while GAP shows higher work of adhesion. Both in vitro release study and in silico simulation indicated that processed films can provide effective drug transport through the buccal mucosa. In silico simulation shows improved bioavailability from buccal films, in comparison to the immediate-release tablets-indicating that the therapeutic drug dose can be markedly reduced.", journal = "Pharmaceutics", title = "Mucoadhesive Gelatin Buccal Films with Propranolol Hydrochloride: Evaluation of Mechanical, Mucoadhesive, and Biopharmaceutical Properties", number = "2", volume = "13", doi = "10.3390/pharmaceutics13020273" }
Jovanović, M., Tomić, N., Cvijic, S., Stojanović, D., Ibric, S.,& Uskoković, P.. (2021). Mucoadhesive Gelatin Buccal Films with Propranolol Hydrochloride: Evaluation of Mechanical, Mucoadhesive, and Biopharmaceutical Properties. in Pharmaceutics, 13(2). https://doi.org/10.3390/pharmaceutics13020273
Jovanović M, Tomić N, Cvijic S, Stojanović D, Ibric S, Uskoković P. Mucoadhesive Gelatin Buccal Films with Propranolol Hydrochloride: Evaluation of Mechanical, Mucoadhesive, and Biopharmaceutical Properties. in Pharmaceutics. 2021;13(2). doi:10.3390/pharmaceutics13020273 .
Jovanović, Marija, Tomić, Nataša, Cvijic, Sandra, Stojanović, Dušica, Ibric, Svetlana, Uskoković, Petar, "Mucoadhesive Gelatin Buccal Films with Propranolol Hydrochloride: Evaluation of Mechanical, Mucoadhesive, and Biopharmaceutical Properties" in Pharmaceutics, 13, no. 2 (2021), https://doi.org/10.3390/pharmaceutics13020273 . .