Utilization of supercritical carbon dioxide for development of antibacterial surgical sutures
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2022
Authors
Pajnik, JelenaMilovanović, Stoja
Stojanović, Dušica
Dimitrijević-Branković, Suzana
Janković-Častvan, Ivona
Uskoković, Petar
Article (Published version)
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Outbreak of surgical infections and bacterial resistance against synthetic antibiotic has prompted research towards development of antibacterial medical devices. For that purpose, absorbable surgical sutures were impregnated with natural compound thymol using an environmentally friendly medium. The supercritical solvent impregnation process was performed at 35 degrees C and 10 MPa during 1, 2, 3 and 6 h, resulting in thymol loadings of 3.9-5.6%. All tested samples expressed antibacterial activity against E. coli and S. aureus. Release tests in PBS at 37 degrees C showed that impregnated material released loaded thymol in a gradual manner. While sutures impregnated during 6 h released complete amount of loaded thymol during 6 days, shorter impregnation process resulted in sutures that retained significant thymol amounts (similar to 20-40%) after 10 days of release test. The effect of proposed process on final material properties and its application were explained in detail using charact...erization techniques SEM, FTIR, DSC and DMA.
Keywords:
Antibacterial activity / Impregnation / Supercritical CO2 / Surgical suture / ThymolSource:
Journal of Supercritical Fluids, 2022, 181, 105490-Publisher:
- Elsevier B.V.
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200287 (Innovation Center of the Faculty of Technology and Metallurgy) (RS-MESTD-inst-2020-200287)
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200135 (University of Belgrade, Faculty of Technology and Metallurgy) (RS-MESTD-inst-2020-200135)
DOI: 10.1016/j.supflu.2021.105490
ISSN: 0896-8446
WoS: 000724256800002
Scopus: 2-s2.0-85120036997
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Inovacioni centarTY - JOUR AU - Pajnik, Jelena AU - Milovanović, Stoja AU - Stojanović, Dušica AU - Dimitrijević-Branković, Suzana AU - Janković-Častvan, Ivona AU - Uskoković, Petar PY - 2022 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4979 AB - Outbreak of surgical infections and bacterial resistance against synthetic antibiotic has prompted research towards development of antibacterial medical devices. For that purpose, absorbable surgical sutures were impregnated with natural compound thymol using an environmentally friendly medium. The supercritical solvent impregnation process was performed at 35 degrees C and 10 MPa during 1, 2, 3 and 6 h, resulting in thymol loadings of 3.9-5.6%. All tested samples expressed antibacterial activity against E. coli and S. aureus. Release tests in PBS at 37 degrees C showed that impregnated material released loaded thymol in a gradual manner. While sutures impregnated during 6 h released complete amount of loaded thymol during 6 days, shorter impregnation process resulted in sutures that retained significant thymol amounts (similar to 20-40%) after 10 days of release test. The effect of proposed process on final material properties and its application were explained in detail using characterization techniques SEM, FTIR, DSC and DMA. PB - Elsevier B.V. T2 - Journal of Supercritical Fluids T1 - Utilization of supercritical carbon dioxide for development of antibacterial surgical sutures SP - 105490 VL - 181 DO - 10.1016/j.supflu.2021.105490 ER -
@article{ author = "Pajnik, Jelena and Milovanović, Stoja and Stojanović, Dušica and Dimitrijević-Branković, Suzana and Janković-Častvan, Ivona and Uskoković, Petar", year = "2022", abstract = "Outbreak of surgical infections and bacterial resistance against synthetic antibiotic has prompted research towards development of antibacterial medical devices. For that purpose, absorbable surgical sutures were impregnated with natural compound thymol using an environmentally friendly medium. The supercritical solvent impregnation process was performed at 35 degrees C and 10 MPa during 1, 2, 3 and 6 h, resulting in thymol loadings of 3.9-5.6%. All tested samples expressed antibacterial activity against E. coli and S. aureus. Release tests in PBS at 37 degrees C showed that impregnated material released loaded thymol in a gradual manner. While sutures impregnated during 6 h released complete amount of loaded thymol during 6 days, shorter impregnation process resulted in sutures that retained significant thymol amounts (similar to 20-40%) after 10 days of release test. The effect of proposed process on final material properties and its application were explained in detail using characterization techniques SEM, FTIR, DSC and DMA.", publisher = "Elsevier B.V.", journal = "Journal of Supercritical Fluids", title = "Utilization of supercritical carbon dioxide for development of antibacterial surgical sutures", pages = "105490", volume = "181", doi = "10.1016/j.supflu.2021.105490" }
Pajnik, J., Milovanović, S., Stojanović, D., Dimitrijević-Branković, S., Janković-Častvan, I.,& Uskoković, P.. (2022). Utilization of supercritical carbon dioxide for development of antibacterial surgical sutures. in Journal of Supercritical Fluids Elsevier B.V.., 181, 105490. https://doi.org/10.1016/j.supflu.2021.105490
Pajnik J, Milovanović S, Stojanović D, Dimitrijević-Branković S, Janković-Častvan I, Uskoković P. Utilization of supercritical carbon dioxide for development of antibacterial surgical sutures. in Journal of Supercritical Fluids. 2022;181:105490. doi:10.1016/j.supflu.2021.105490 .
Pajnik, Jelena, Milovanović, Stoja, Stojanović, Dušica, Dimitrijević-Branković, Suzana, Janković-Častvan, Ivona, Uskoković, Petar, "Utilization of supercritical carbon dioxide for development of antibacterial surgical sutures" in Journal of Supercritical Fluids, 181 (2022):105490, https://doi.org/10.1016/j.supflu.2021.105490 . .