Utilization of supercritical carbon dioxide for development of antibacterial surgical sutures
Samo za registrovane korisnike
2022
Autori
Pajnik, JelenaMilovanović, Stoja
Stojanović, Dušica
Dimitrijević-Branković, Suzana
Janković-Častvan, Ivona
Uskoković, Petar
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Outbreak of surgical infections and bacterial resistance against synthetic antibiotic has prompted research towards development of antibacterial medical devices. For that purpose, absorbable surgical sutures were impregnated with natural compound thymol using an environmentally friendly medium. The supercritical solvent impregnation process was performed at 35 degrees C and 10 MPa during 1, 2, 3 and 6 h, resulting in thymol loadings of 3.9-5.6%. All tested samples expressed antibacterial activity against E. coli and S. aureus. Release tests in PBS at 37 degrees C showed that impregnated material released loaded thymol in a gradual manner. While sutures impregnated during 6 h released complete amount of loaded thymol during 6 days, shorter impregnation process resulted in sutures that retained significant thymol amounts (similar to 20-40%) after 10 days of release test. The effect of proposed process on final material properties and its application were explained in detail using charact...erization techniques SEM, FTIR, DSC and DMA.
Ključne reči:
Antibacterial activity / Impregnation / Supercritical CO2 / Surgical suture / ThymolIzvor:
Journal of Supercritical Fluids, 2022, 181, 105490-Izdavač:
- Elsevier B.V.
Finansiranje / projekti:
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200287 (Inovacioni centar Tehnološko-metalurškog fakulteta u Beogradu doo) (RS-MESTD-inst-2020-200287)
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200135 (Univerzitet u Beogradu, Tehnološko-metalurški fakultet) (RS-MESTD-inst-2020-200135)
DOI: 10.1016/j.supflu.2021.105490
ISSN: 0896-8446
WoS: 000724256800002
Scopus: 2-s2.0-85120036997
Kolekcije
Institucija/grupa
Inovacioni centarTY - JOUR AU - Pajnik, Jelena AU - Milovanović, Stoja AU - Stojanović, Dušica AU - Dimitrijević-Branković, Suzana AU - Janković-Častvan, Ivona AU - Uskoković, Petar PY - 2022 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4979 AB - Outbreak of surgical infections and bacterial resistance against synthetic antibiotic has prompted research towards development of antibacterial medical devices. For that purpose, absorbable surgical sutures were impregnated with natural compound thymol using an environmentally friendly medium. The supercritical solvent impregnation process was performed at 35 degrees C and 10 MPa during 1, 2, 3 and 6 h, resulting in thymol loadings of 3.9-5.6%. All tested samples expressed antibacterial activity against E. coli and S. aureus. Release tests in PBS at 37 degrees C showed that impregnated material released loaded thymol in a gradual manner. While sutures impregnated during 6 h released complete amount of loaded thymol during 6 days, shorter impregnation process resulted in sutures that retained significant thymol amounts (similar to 20-40%) after 10 days of release test. The effect of proposed process on final material properties and its application were explained in detail using characterization techniques SEM, FTIR, DSC and DMA. PB - Elsevier B.V. T2 - Journal of Supercritical Fluids T1 - Utilization of supercritical carbon dioxide for development of antibacterial surgical sutures SP - 105490 VL - 181 DO - 10.1016/j.supflu.2021.105490 ER -
@article{ author = "Pajnik, Jelena and Milovanović, Stoja and Stojanović, Dušica and Dimitrijević-Branković, Suzana and Janković-Častvan, Ivona and Uskoković, Petar", year = "2022", abstract = "Outbreak of surgical infections and bacterial resistance against synthetic antibiotic has prompted research towards development of antibacterial medical devices. For that purpose, absorbable surgical sutures were impregnated with natural compound thymol using an environmentally friendly medium. The supercritical solvent impregnation process was performed at 35 degrees C and 10 MPa during 1, 2, 3 and 6 h, resulting in thymol loadings of 3.9-5.6%. All tested samples expressed antibacterial activity against E. coli and S. aureus. Release tests in PBS at 37 degrees C showed that impregnated material released loaded thymol in a gradual manner. While sutures impregnated during 6 h released complete amount of loaded thymol during 6 days, shorter impregnation process resulted in sutures that retained significant thymol amounts (similar to 20-40%) after 10 days of release test. The effect of proposed process on final material properties and its application were explained in detail using characterization techniques SEM, FTIR, DSC and DMA.", publisher = "Elsevier B.V.", journal = "Journal of Supercritical Fluids", title = "Utilization of supercritical carbon dioxide for development of antibacterial surgical sutures", pages = "105490", volume = "181", doi = "10.1016/j.supflu.2021.105490" }
Pajnik, J., Milovanović, S., Stojanović, D., Dimitrijević-Branković, S., Janković-Častvan, I.,& Uskoković, P.. (2022). Utilization of supercritical carbon dioxide for development of antibacterial surgical sutures. in Journal of Supercritical Fluids Elsevier B.V.., 181, 105490. https://doi.org/10.1016/j.supflu.2021.105490
Pajnik J, Milovanović S, Stojanović D, Dimitrijević-Branković S, Janković-Častvan I, Uskoković P. Utilization of supercritical carbon dioxide for development of antibacterial surgical sutures. in Journal of Supercritical Fluids. 2022;181:105490. doi:10.1016/j.supflu.2021.105490 .
Pajnik, Jelena, Milovanović, Stoja, Stojanović, Dušica, Dimitrijević-Branković, Suzana, Janković-Častvan, Ivona, Uskoković, Petar, "Utilization of supercritical carbon dioxide for development of antibacterial surgical sutures" in Journal of Supercritical Fluids, 181 (2022):105490, https://doi.org/10.1016/j.supflu.2021.105490 . .