In vitro evaluation of the controlled release of antibiotics from liposomes
In vitro ispitivanje kontrolisanog otpuštanja antibiotika iz liposoma
Апстракт
Results of this study have shown significantly prolonged release of selected antibiotic from liposome dispersion as compared to free antibiotic solution of the same initial concentration. Two models of non-steady one-dimensional diffusion were successfully applied to the experimental data and the antibiotic diffusion coefficients were estimated. In addition, the mass transfer resistance of the membrane was shown to be insignificant confirming the suitability of the applied experimental system. Since liposomes are known as systems with slower drug release, then, when it comes to their incorporation in the final form of a preparation for further experiments in vivo, the system of choice would be liposomes with an encapsulated antibiotic drug. Tfie established experimental system could be extended to other liposome formulations with respect to the release rate of the active components.
Кључне речи:
Controlled release / Diffusion / Liposomes / Membrane module / ModelingИзвор:
Chemical Industry & Chemical Engineering Quarterly, 2003, 9, 4, 589-595Издавач:
- Association of the Chemical Engineers of Serbia
Институција/група
Tehnološko-metalurški fakultetTY - JOUR AU - Boltić, Zorana AU - Petkovska, Menka AU - Obradović, Bojana AU - Nedović, Viktor AU - Bugarski, Branko PY - 2003 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/501 AB - Results of this study have shown significantly prolonged release of selected antibiotic from liposome dispersion as compared to free antibiotic solution of the same initial concentration. Two models of non-steady one-dimensional diffusion were successfully applied to the experimental data and the antibiotic diffusion coefficients were estimated. In addition, the mass transfer resistance of the membrane was shown to be insignificant confirming the suitability of the applied experimental system. Since liposomes are known as systems with slower drug release, then, when it comes to their incorporation in the final form of a preparation for further experiments in vivo, the system of choice would be liposomes with an encapsulated antibiotic drug. Tfie established experimental system could be extended to other liposome formulations with respect to the release rate of the active components. PB - Association of the Chemical Engineers of Serbia T2 - Chemical Industry & Chemical Engineering Quarterly T1 - In vitro evaluation of the controlled release of antibiotics from liposomes T1 - In vitro ispitivanje kontrolisanog otpuštanja antibiotika iz liposoma EP - 595 IS - 4 SP - 589 VL - 9 DO - 10.2298/HEMIND0312589B ER -
@article{ author = "Boltić, Zorana and Petkovska, Menka and Obradović, Bojana and Nedović, Viktor and Bugarski, Branko", year = "2003", abstract = "Results of this study have shown significantly prolonged release of selected antibiotic from liposome dispersion as compared to free antibiotic solution of the same initial concentration. Two models of non-steady one-dimensional diffusion were successfully applied to the experimental data and the antibiotic diffusion coefficients were estimated. In addition, the mass transfer resistance of the membrane was shown to be insignificant confirming the suitability of the applied experimental system. Since liposomes are known as systems with slower drug release, then, when it comes to their incorporation in the final form of a preparation for further experiments in vivo, the system of choice would be liposomes with an encapsulated antibiotic drug. Tfie established experimental system could be extended to other liposome formulations with respect to the release rate of the active components.", publisher = "Association of the Chemical Engineers of Serbia", journal = "Chemical Industry & Chemical Engineering Quarterly", title = "In vitro evaluation of the controlled release of antibiotics from liposomes, In vitro ispitivanje kontrolisanog otpuštanja antibiotika iz liposoma", pages = "595-589", number = "4", volume = "9", doi = "10.2298/HEMIND0312589B" }
Boltić, Z., Petkovska, M., Obradović, B., Nedović, V.,& Bugarski, B.. (2003). In vitro evaluation of the controlled release of antibiotics from liposomes. in Chemical Industry & Chemical Engineering Quarterly Association of the Chemical Engineers of Serbia., 9(4), 589-595. https://doi.org/10.2298/HEMIND0312589B
Boltić Z, Petkovska M, Obradović B, Nedović V, Bugarski B. In vitro evaluation of the controlled release of antibiotics from liposomes. in Chemical Industry & Chemical Engineering Quarterly. 2003;9(4):589-595. doi:10.2298/HEMIND0312589B .
Boltić, Zorana, Petkovska, Menka, Obradović, Bojana, Nedović, Viktor, Bugarski, Branko, "In vitro evaluation of the controlled release of antibiotics from liposomes" in Chemical Industry & Chemical Engineering Quarterly, 9, no. 4 (2003):589-595, https://doi.org/10.2298/HEMIND0312589B . .