Three dimensional polymeric networks based on poly(methacrylic acid) and protein for targeted delivery of poorly water-soluble drugs
Само за регистроване кориснике
2019
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Three dimensional polymer networks, hydrogels, have shown a great potential in
controlled release and targeted delivery of active substances. pH sensitive hydrogels
based on poly(methacrylic acid) have attracted significant attention due to their
biocompatibility, non-toxicity and the possession of the huge number of ionogenic
carboxylic groups. On the other hand, the usage of these hydrogels for controlled release
and targeted delivery of poorly water-soluble drugs is limited by their highly hydrophilic
nature. We overcame this limitation by modifying PMAA with amphiphilic substance -
casein. The addition of this natural protein enabled the encapsulation, targeted delivery
and controlled release of poorly water-soluble model drug - caffeine. Three carriers with
different neutralization degree of methacrylic acid were synthesized via free radical
polymerization. The FTIR spectra revealed that two types of interactions were
established between casein and caffeine: hydrophobic... interactions and hydrogen bonds.
The SEM micrographs showed that the structure of the carriers depended on the change
of neutralization degree of the methacrylic acid. The swelling of synthesized carriers and
the caffeine in vitro release were monitored in two environments at 37°C: 0.1M HCl
pH=1.2 (simulation of environment in human stomach) and phosphate buffer pH=6.8
(simulation of environment in human intestines). The synthesized carriers had higher
swelling degree and the higher release rate of caffeine in the phosphate buffer pH=6.8
than in 0.1M HCl. The increase in neutralization degree of methacrylic acid caused the
increase in swelling degree of the carriers and the increase in release rate of caffeine.
Presented results showed that synthesized carriers are promising candidates for targeted
delivery of poorly water-soluble drugs.
Извор:
Conference of the Young Chemists of Serbia, 2019, 134-Издавач:
- Serbian Chemical Society and Serbian Young Chemists Club Karnegijeva 4/III, 11000 Belgrade, Serbia
Финансирање / пројекти:
- Развој нових инкапсулационих и ензимских технологија за производњу биокатализатора и биолошки активних компонената хране у циљу повећања њене конкурентности, квалитета и безбедности (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-46010)
- Синтеза и карактеризација нових функционалних полимера и полимерних нанокомпозита (RS-MESTD-Basic Research (BR or ON)-172062)
Колекције
Институција/група
Inovacioni centarTY - CONF AU - Marković, Maja D. AU - Seslija, Sanja I. AU - Panić, Vesna V. AU - Pjanović, Rada V. PY - 2019 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5074 AB - Three dimensional polymer networks, hydrogels, have shown a great potential in controlled release and targeted delivery of active substances. pH sensitive hydrogels based on poly(methacrylic acid) have attracted significant attention due to their biocompatibility, non-toxicity and the possession of the huge number of ionogenic carboxylic groups. On the other hand, the usage of these hydrogels for controlled release and targeted delivery of poorly water-soluble drugs is limited by their highly hydrophilic nature. We overcame this limitation by modifying PMAA with amphiphilic substance - casein. The addition of this natural protein enabled the encapsulation, targeted delivery and controlled release of poorly water-soluble model drug - caffeine. Three carriers with different neutralization degree of methacrylic acid were synthesized via free radical polymerization. The FTIR spectra revealed that two types of interactions were established between casein and caffeine: hydrophobic interactions and hydrogen bonds. The SEM micrographs showed that the structure of the carriers depended on the change of neutralization degree of the methacrylic acid. The swelling of synthesized carriers and the caffeine in vitro release were monitored in two environments at 37°C: 0.1M HCl pH=1.2 (simulation of environment in human stomach) and phosphate buffer pH=6.8 (simulation of environment in human intestines). The synthesized carriers had higher swelling degree and the higher release rate of caffeine in the phosphate buffer pH=6.8 than in 0.1M HCl. The increase in neutralization degree of methacrylic acid caused the increase in swelling degree of the carriers and the increase in release rate of caffeine. Presented results showed that synthesized carriers are promising candidates for targeted delivery of poorly water-soluble drugs. PB - Serbian Chemical Society and Serbian Young Chemists Club Karnegijeva 4/III, 11000 Belgrade, Serbia C3 - Conference of the Young Chemists of Serbia T1 - Three dimensional polymeric networks based on poly(methacrylic acid) and protein for targeted delivery of poorly water-soluble drugs SP - 134 UR - https://hdl.handle.net/21.15107/rcub_technorep_5074 ER -
@conference{ author = "Marković, Maja D. and Seslija, Sanja I. and Panić, Vesna V. and Pjanović, Rada V.", year = "2019", abstract = "Three dimensional polymer networks, hydrogels, have shown a great potential in controlled release and targeted delivery of active substances. pH sensitive hydrogels based on poly(methacrylic acid) have attracted significant attention due to their biocompatibility, non-toxicity and the possession of the huge number of ionogenic carboxylic groups. On the other hand, the usage of these hydrogels for controlled release and targeted delivery of poorly water-soluble drugs is limited by their highly hydrophilic nature. We overcame this limitation by modifying PMAA with amphiphilic substance - casein. The addition of this natural protein enabled the encapsulation, targeted delivery and controlled release of poorly water-soluble model drug - caffeine. Three carriers with different neutralization degree of methacrylic acid were synthesized via free radical polymerization. The FTIR spectra revealed that two types of interactions were established between casein and caffeine: hydrophobic interactions and hydrogen bonds. The SEM micrographs showed that the structure of the carriers depended on the change of neutralization degree of the methacrylic acid. The swelling of synthesized carriers and the caffeine in vitro release were monitored in two environments at 37°C: 0.1M HCl pH=1.2 (simulation of environment in human stomach) and phosphate buffer pH=6.8 (simulation of environment in human intestines). The synthesized carriers had higher swelling degree and the higher release rate of caffeine in the phosphate buffer pH=6.8 than in 0.1M HCl. The increase in neutralization degree of methacrylic acid caused the increase in swelling degree of the carriers and the increase in release rate of caffeine. Presented results showed that synthesized carriers are promising candidates for targeted delivery of poorly water-soluble drugs.", publisher = "Serbian Chemical Society and Serbian Young Chemists Club Karnegijeva 4/III, 11000 Belgrade, Serbia", journal = "Conference of the Young Chemists of Serbia", title = "Three dimensional polymeric networks based on poly(methacrylic acid) and protein for targeted delivery of poorly water-soluble drugs", pages = "134", url = "https://hdl.handle.net/21.15107/rcub_technorep_5074" }
Marković, M. D., Seslija, S. I., Panić, V. V.,& Pjanović, R. V.. (2019). Three dimensional polymeric networks based on poly(methacrylic acid) and protein for targeted delivery of poorly water-soluble drugs. in Conference of the Young Chemists of Serbia Serbian Chemical Society and Serbian Young Chemists Club Karnegijeva 4/III, 11000 Belgrade, Serbia., 134. https://hdl.handle.net/21.15107/rcub_technorep_5074
Marković MD, Seslija SI, Panić VV, Pjanović RV. Three dimensional polymeric networks based on poly(methacrylic acid) and protein for targeted delivery of poorly water-soluble drugs. in Conference of the Young Chemists of Serbia. 2019;:134. https://hdl.handle.net/21.15107/rcub_technorep_5074 .
Marković, Maja D., Seslija, Sanja I., Panić, Vesna V., Pjanović, Rada V., "Three dimensional polymeric networks based on poly(methacrylic acid) and protein for targeted delivery of poorly water-soluble drugs" in Conference of the Young Chemists of Serbia (2019):134, https://hdl.handle.net/21.15107/rcub_technorep_5074 .