Methionine Capped Nanoparticles as Acetylcholinesterase Inhibitors
Samo za registrovane korisnike
2023
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The silver and gold L-methionine capped nanoparticles (Ag and Au @LM NPs) were analyzed as prospective acetylcholinesterase (AChE) inhibitors to test their potential in the treatment of cognitive impairment in depression and Alzheimer's disease. The stability of NPs, and their ability to inhibit AChE were studied by UV-Vis and FTIR spectrophotometry. At the same time, TEM and SEM measurements, DLS, and zeta potential measurements were employed in the structural characterization of NPs. Nearly spherical, negatively charged Ag and Au @LM NPs, with 17 nm and 31 nm in diameter, respectively, showed moderate inhibitory potential toward AChE in the given frame of investigated concentrations. For both NPs IC50 is not reached. Furthermore, the adsorption of enzyme molecules on the surface of Ag and Au @LM NPs was demonstrated. Hence, our assumption is that inhibition of AChE is caused by blockage of the enzyme‘s active site due to the steric hindrance of NPs.
Ključne reči:
acetylcholinesterase / alzheimer‘s disease / gold / inhibition / nanoparticles / silverIzvor:
European Journal of Inorganic Chemistry, 2023, e202200754-Izdavač:
- John Wiley and Sons Inc.
Finansiranje / projekti:
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200123 (Univerzitet u Prištini sa privremenim sedištem u Kosovskoj Mitrovici, Prirodno-matematički fakultet) (RS-MESTD-inst-2020-200123)
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200017 (Univerzitet u Beogradu, Institut za nuklearne nauke Vinča, Beograd-Vinča) (RS-MESTD-inst-2020-200017)
DOI: 10.1002/ejic.202200754
ISSN: 1434-1948
WoS: 000945620400001
Scopus: 2-s2.0-85149470213
Institucija/grupa
Tehnološko-metalurški fakultetTY - JOUR AU - Laban, Bojana B. AU - Lazarević-Pašti, Tamara AU - Veljović, Đorđe AU - Marković, Mirjana AU - Klekotka, Urszula PY - 2023 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6222 AB - The silver and gold L-methionine capped nanoparticles (Ag and Au @LM NPs) were analyzed as prospective acetylcholinesterase (AChE) inhibitors to test their potential in the treatment of cognitive impairment in depression and Alzheimer's disease. The stability of NPs, and their ability to inhibit AChE were studied by UV-Vis and FTIR spectrophotometry. At the same time, TEM and SEM measurements, DLS, and zeta potential measurements were employed in the structural characterization of NPs. Nearly spherical, negatively charged Ag and Au @LM NPs, with 17 nm and 31 nm in diameter, respectively, showed moderate inhibitory potential toward AChE in the given frame of investigated concentrations. For both NPs IC50 is not reached. Furthermore, the adsorption of enzyme molecules on the surface of Ag and Au @LM NPs was demonstrated. Hence, our assumption is that inhibition of AChE is caused by blockage of the enzyme‘s active site due to the steric hindrance of NPs. PB - John Wiley and Sons Inc. T2 - European Journal of Inorganic Chemistry T1 - Methionine Capped Nanoparticles as Acetylcholinesterase Inhibitors SP - e202200754 DO - 10.1002/ejic.202200754 ER -
@article{ author = "Laban, Bojana B. and Lazarević-Pašti, Tamara and Veljović, Đorđe and Marković, Mirjana and Klekotka, Urszula", year = "2023", abstract = "The silver and gold L-methionine capped nanoparticles (Ag and Au @LM NPs) were analyzed as prospective acetylcholinesterase (AChE) inhibitors to test their potential in the treatment of cognitive impairment in depression and Alzheimer's disease. The stability of NPs, and their ability to inhibit AChE were studied by UV-Vis and FTIR spectrophotometry. At the same time, TEM and SEM measurements, DLS, and zeta potential measurements were employed in the structural characterization of NPs. Nearly spherical, negatively charged Ag and Au @LM NPs, with 17 nm and 31 nm in diameter, respectively, showed moderate inhibitory potential toward AChE in the given frame of investigated concentrations. For both NPs IC50 is not reached. Furthermore, the adsorption of enzyme molecules on the surface of Ag and Au @LM NPs was demonstrated. Hence, our assumption is that inhibition of AChE is caused by blockage of the enzyme‘s active site due to the steric hindrance of NPs.", publisher = "John Wiley and Sons Inc.", journal = "European Journal of Inorganic Chemistry", title = "Methionine Capped Nanoparticles as Acetylcholinesterase Inhibitors", pages = "e202200754", doi = "10.1002/ejic.202200754" }
Laban, B. B., Lazarević-Pašti, T., Veljović, Đ., Marković, M.,& Klekotka, U.. (2023). Methionine Capped Nanoparticles as Acetylcholinesterase Inhibitors. in European Journal of Inorganic Chemistry John Wiley and Sons Inc.., e202200754. https://doi.org/10.1002/ejic.202200754
Laban BB, Lazarević-Pašti T, Veljović Đ, Marković M, Klekotka U. Methionine Capped Nanoparticles as Acetylcholinesterase Inhibitors. in European Journal of Inorganic Chemistry. 2023;:e202200754. doi:10.1002/ejic.202200754 .
Laban, Bojana B., Lazarević-Pašti, Tamara, Veljović, Đorđe, Marković, Mirjana, Klekotka, Urszula, "Methionine Capped Nanoparticles as Acetylcholinesterase Inhibitors" in European Journal of Inorganic Chemistry (2023):e202200754, https://doi.org/10.1002/ejic.202200754 . .