dc.creator | Radonjić, Mia | |
dc.creator | Zvicer, Jovana | |
dc.creator | Obradović, Bojana | |
dc.date.accessioned | 2023-04-04T09:13:40Z | |
dc.date.available | 2023-04-04T09:13:40Z | |
dc.date.issued | 2017 | |
dc.identifier.isbn | 978-86-80321-34-9 | |
dc.identifier.uri | http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6347 | |
dc.description.abstract | Scaffolds used for osteochondral tissue engineering should comprise two distinct regions: a
bottom region with characteristics corresponding to bone tissue, such as a porous structure
with mineral components (predominantly hydroxyapatite), and a top region with
characteristics of articular cartilage, which is gelatinous with high water content. In this
work, we have investigated possibilities to formulate and optimize a procedure for obtaining
such biphasic scaffolds based on gellan gum (GG). A porous base layer of the scaffold was
obtained by lyophilization of the 2 % GG hydrogel with dispersed bioactive glass
nanoparticles, as hydroxyapatite precursors. Next, different procedures were investigated to
produce the upper GG hydrogel such as partial immersion of the porous layer in the GG
solution and pouring the GG solution over the porous layer at different moisture conditions
and temperatures. A simple mathematical model was derived and subsequently
experimentally validated to find optimal temperatures of the porous layer, GG solution and
the surrounding environment to provide adequate gelation rate to form the GG hydrogel on
top of the porous layer with a thin interfacial zone. | sr |
dc.language.iso | en | sr |
dc.publisher | Institute of Technical Sciences of SASA | sr |
dc.rights | openAccess | sr |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Seventieth Young Researchers’ Conference - Materials Science and Engineering: Programme and the Book of Abstracts | sr |
dc.title | Development and optimization of the production procedure of biphasic scaffolds for osteochondral tissue engineering | sr |
dc.type | conferenceObject | sr |
dc.rights.license | BY | sr |
dc.citation.spage | 4 | |
dc.identifier.fulltext | http://TechnoRep.tmf.bg.ac.rs/bitstream/id/16975/17YRC2018-1-5_merged.pdf | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_technorep_6347 | |
dc.type.version | publishedVersion | sr |