Bio-based products from lactic acid bacteria
Abstract
Lactic acid bacteria (LAB) are a diverse group of microorganisms with lactic acid
production as a common characteristic. LAB are part of the human diet from the first
days of life, as part of breast milk microbiota, throughout life. Since ancient times, LAB
ferment dairy and meat products, beverages or cereals contributing to preservation,
flavor and texture of food, but also to a health status of the host, since many are
probiotics. Their capability to interact with host immunity and colonize gut makes them
particularly interesting as vectors for oral vaccine, bacteriophage therapy, synthetic
biology and for a personalized approach to treatment.
Production of lactic acid by LAB from renewable substrates is another extremely
active field of research today. Cheaper and more sustainable production of lactic acid is
a goal. Lactic acid as a platform chemical can be valorized in different ways, but currently
the highest expansion is in the field of poly-lactic acid polymer produ...ction. Poly-lactic
acid polymers are the most represented biocompatible and biodegradable plastic used
for various applications, including biomedicine.
Other compounds like exopolysaccharides are naturally excreted by LAB, with the aim
to protect cells and to help retention on surfaces. These characteristics are promising for
their application as excipients for pharmaceutical formulations. LAB are also producing
bacteriocines, antimicrobial peptides which enable colonization of the gut. Live LAB
biomass or some of these products or even attenuated LAB biomass has proven
successful in altering response of the host to the stressful environmental condition.
LAB participate in the symbiosis of the human body and its microbiota interacting
through metabolism, immunity, bioavailability and biotransformation of the food and
drugs we take. Additionally, microbial communities are dynamic and different in every
person. This leads to the untapped potential for their exploitation and necessity to
better understand their role both inside and outside the human body.
Keywords:
lactic acid / probiotics / biomass / exopolysaccharides / bacteriocines / personalized approach to treatmentSource:
Book of abstracts / The 2nd Balkans-China Mini-symposium on Natural Products and Drug Discovery, 11-13 April, 2019 Belgrade, Serbia, 2019, 15-Publisher:
- Belgrade : Institute for Biological Research "Siniša Stanković", University of Belgrade
Collections
Institution/Community
Tehnološko-metalurški fakultetTY - CONF AU - Đukić-Vuković, Aleksandra AU - Mladenović, Dragana AU - Mojović, Ljiljana PY - 2019 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6912 AB - Lactic acid bacteria (LAB) are a diverse group of microorganisms with lactic acid production as a common characteristic. LAB are part of the human diet from the first days of life, as part of breast milk microbiota, throughout life. Since ancient times, LAB ferment dairy and meat products, beverages or cereals contributing to preservation, flavor and texture of food, but also to a health status of the host, since many are probiotics. Their capability to interact with host immunity and colonize gut makes them particularly interesting as vectors for oral vaccine, bacteriophage therapy, synthetic biology and for a personalized approach to treatment. Production of lactic acid by LAB from renewable substrates is another extremely active field of research today. Cheaper and more sustainable production of lactic acid is a goal. Lactic acid as a platform chemical can be valorized in different ways, but currently the highest expansion is in the field of poly-lactic acid polymer production. Poly-lactic acid polymers are the most represented biocompatible and biodegradable plastic used for various applications, including biomedicine. Other compounds like exopolysaccharides are naturally excreted by LAB, with the aim to protect cells and to help retention on surfaces. These characteristics are promising for their application as excipients for pharmaceutical formulations. LAB are also producing bacteriocines, antimicrobial peptides which enable colonization of the gut. Live LAB biomass or some of these products or even attenuated LAB biomass has proven successful in altering response of the host to the stressful environmental condition. LAB participate in the symbiosis of the human body and its microbiota interacting through metabolism, immunity, bioavailability and biotransformation of the food and drugs we take. Additionally, microbial communities are dynamic and different in every person. This leads to the untapped potential for their exploitation and necessity to better understand their role both inside and outside the human body. PB - Belgrade : Institute for Biological Research "Siniša Stanković", University of Belgrade C3 - Book of abstracts / The 2nd Balkans-China Mini-symposium on Natural Products and Drug Discovery, 11-13 April, 2019 Belgrade, Serbia T1 - Bio-based products from lactic acid bacteria SP - 15 UR - https://hdl.handle.net/21.15107/rcub_technorep_6912 ER -
@conference{ author = "Đukić-Vuković, Aleksandra and Mladenović, Dragana and Mojović, Ljiljana", year = "2019", abstract = "Lactic acid bacteria (LAB) are a diverse group of microorganisms with lactic acid production as a common characteristic. LAB are part of the human diet from the first days of life, as part of breast milk microbiota, throughout life. Since ancient times, LAB ferment dairy and meat products, beverages or cereals contributing to preservation, flavor and texture of food, but also to a health status of the host, since many are probiotics. Their capability to interact with host immunity and colonize gut makes them particularly interesting as vectors for oral vaccine, bacteriophage therapy, synthetic biology and for a personalized approach to treatment. Production of lactic acid by LAB from renewable substrates is another extremely active field of research today. Cheaper and more sustainable production of lactic acid is a goal. Lactic acid as a platform chemical can be valorized in different ways, but currently the highest expansion is in the field of poly-lactic acid polymer production. Poly-lactic acid polymers are the most represented biocompatible and biodegradable plastic used for various applications, including biomedicine. Other compounds like exopolysaccharides are naturally excreted by LAB, with the aim to protect cells and to help retention on surfaces. These characteristics are promising for their application as excipients for pharmaceutical formulations. LAB are also producing bacteriocines, antimicrobial peptides which enable colonization of the gut. Live LAB biomass or some of these products or even attenuated LAB biomass has proven successful in altering response of the host to the stressful environmental condition. LAB participate in the symbiosis of the human body and its microbiota interacting through metabolism, immunity, bioavailability and biotransformation of the food and drugs we take. Additionally, microbial communities are dynamic and different in every person. This leads to the untapped potential for their exploitation and necessity to better understand their role both inside and outside the human body.", publisher = "Belgrade : Institute for Biological Research "Siniša Stanković", University of Belgrade", journal = "Book of abstracts / The 2nd Balkans-China Mini-symposium on Natural Products and Drug Discovery, 11-13 April, 2019 Belgrade, Serbia", title = "Bio-based products from lactic acid bacteria", pages = "15", url = "https://hdl.handle.net/21.15107/rcub_technorep_6912" }
Đukić-Vuković, A., Mladenović, D.,& Mojović, L.. (2019). Bio-based products from lactic acid bacteria. in Book of abstracts / The 2nd Balkans-China Mini-symposium on Natural Products and Drug Discovery, 11-13 April, 2019 Belgrade, Serbia Belgrade : Institute for Biological Research "Siniša Stanković", University of Belgrade., 15. https://hdl.handle.net/21.15107/rcub_technorep_6912
Đukić-Vuković A, Mladenović D, Mojović L. Bio-based products from lactic acid bacteria. in Book of abstracts / The 2nd Balkans-China Mini-symposium on Natural Products and Drug Discovery, 11-13 April, 2019 Belgrade, Serbia. 2019;:15. https://hdl.handle.net/21.15107/rcub_technorep_6912 .
Đukić-Vuković, Aleksandra, Mladenović, Dragana, Mojović, Ljiljana, "Bio-based products from lactic acid bacteria" in Book of abstracts / The 2nd Balkans-China Mini-symposium on Natural Products and Drug Discovery, 11-13 April, 2019 Belgrade, Serbia (2019):15, https://hdl.handle.net/21.15107/rcub_technorep_6912 .