Liposomal and Liposomes-Film Systems as Carriers for Bioactives from Paeonia tenuifolia L. Petals: Physicochemical Characterization and Biological Potential
Autori
Čutović, NatalijaMarković, Tatjana
Carević, Tamara
Stojković, Dejan
Bugarski, Branko
Jovanović, Aleksandra A.
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Paeonia tenuifolia L. (steppe peony) petal extract was proficiently encapsulated into liposomes and biopolymer films in the current work, both times utilizing a single-step procedure. The encapsulation efficiency, size of the particles, and index of polydispersity (PDI), as well as the ζ potential of the obtained liposomes were determined, whereas in the case of films, the test included moisture content and mechanical property assessment. Fourier transform infrared spectroscopy (FT-IR) was used to evaluate the chemical composition and existence of numerous interactions in the systems. All the obtained encapsulates were subjected to antibacterial, antifungal and antibiofilm activity testing of the pathogens associated with human skin. The results indicated that the liposomes prepared using Phospholipon had the highest encapsulation efficiency (72.04%), making them the most favorable ones in the release study as well. The biological assays also revealed that Phospholipon was the most ben...eficial phospholipid mixture for the preparation of liposomes, whereas the film containing these liposomes did not have the ability to inhibit pathogen growth, making the double encapsulation of P. tenuifolia L. petal extract needless. These findings may be a first step toward the potential use of steppe peony extract-loaded films and liposomes in pharmaceutical and cosmetical industries.
Ključne reči:
biological activity / biopolymer films / encapsulation / liposomes / peonyIzvor:
Pharmaceutics, 2023, 15, 12, 2742-Izdavač:
- MDPI
Finansiranje / projekti:
- Ministry of Science and Technology of the Republic of Serbia (451-03-1202/2021-09/3)
- Razvoj tehnologije gajenja kukuruza sa ekološkim pristupom (RS-MESTD-MPN2006-2010-20007)
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200019 (Univerzitet u Beogradu, Institut za primenu nuklearne energije - INEP) (RS-MESTD-inst-2020-200019)
Institucija/grupa
Tehnološko-metalurški fakultetTY - JOUR AU - Čutović, Natalija AU - Marković, Tatjana AU - Carević, Tamara AU - Stojković, Dejan AU - Bugarski, Branko AU - Jovanović, Aleksandra A. PY - 2023 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7073 AB - Paeonia tenuifolia L. (steppe peony) petal extract was proficiently encapsulated into liposomes and biopolymer films in the current work, both times utilizing a single-step procedure. The encapsulation efficiency, size of the particles, and index of polydispersity (PDI), as well as the ζ potential of the obtained liposomes were determined, whereas in the case of films, the test included moisture content and mechanical property assessment. Fourier transform infrared spectroscopy (FT-IR) was used to evaluate the chemical composition and existence of numerous interactions in the systems. All the obtained encapsulates were subjected to antibacterial, antifungal and antibiofilm activity testing of the pathogens associated with human skin. The results indicated that the liposomes prepared using Phospholipon had the highest encapsulation efficiency (72.04%), making them the most favorable ones in the release study as well. The biological assays also revealed that Phospholipon was the most beneficial phospholipid mixture for the preparation of liposomes, whereas the film containing these liposomes did not have the ability to inhibit pathogen growth, making the double encapsulation of P. tenuifolia L. petal extract needless. These findings may be a first step toward the potential use of steppe peony extract-loaded films and liposomes in pharmaceutical and cosmetical industries. PB - MDPI T2 - Pharmaceutics T1 - Liposomal and Liposomes-Film Systems as Carriers for Bioactives from Paeonia tenuifolia L. Petals: Physicochemical Characterization and Biological Potential IS - 12 SP - 2742 VL - 15 DO - 10.3390/pharmaceutics15122742 ER -
@article{ author = "Čutović, Natalija and Marković, Tatjana and Carević, Tamara and Stojković, Dejan and Bugarski, Branko and Jovanović, Aleksandra A.", year = "2023", abstract = "Paeonia tenuifolia L. (steppe peony) petal extract was proficiently encapsulated into liposomes and biopolymer films in the current work, both times utilizing a single-step procedure. The encapsulation efficiency, size of the particles, and index of polydispersity (PDI), as well as the ζ potential of the obtained liposomes were determined, whereas in the case of films, the test included moisture content and mechanical property assessment. Fourier transform infrared spectroscopy (FT-IR) was used to evaluate the chemical composition and existence of numerous interactions in the systems. All the obtained encapsulates were subjected to antibacterial, antifungal and antibiofilm activity testing of the pathogens associated with human skin. The results indicated that the liposomes prepared using Phospholipon had the highest encapsulation efficiency (72.04%), making them the most favorable ones in the release study as well. The biological assays also revealed that Phospholipon was the most beneficial phospholipid mixture for the preparation of liposomes, whereas the film containing these liposomes did not have the ability to inhibit pathogen growth, making the double encapsulation of P. tenuifolia L. petal extract needless. These findings may be a first step toward the potential use of steppe peony extract-loaded films and liposomes in pharmaceutical and cosmetical industries.", publisher = "MDPI", journal = "Pharmaceutics", title = "Liposomal and Liposomes-Film Systems as Carriers for Bioactives from Paeonia tenuifolia L. Petals: Physicochemical Characterization and Biological Potential", number = "12", pages = "2742", volume = "15", doi = "10.3390/pharmaceutics15122742" }
Čutović, N., Marković, T., Carević, T., Stojković, D., Bugarski, B.,& Jovanović, A. A.. (2023). Liposomal and Liposomes-Film Systems as Carriers for Bioactives from Paeonia tenuifolia L. Petals: Physicochemical Characterization and Biological Potential. in Pharmaceutics MDPI., 15(12), 2742. https://doi.org/10.3390/pharmaceutics15122742
Čutović N, Marković T, Carević T, Stojković D, Bugarski B, Jovanović AA. Liposomal and Liposomes-Film Systems as Carriers for Bioactives from Paeonia tenuifolia L. Petals: Physicochemical Characterization and Biological Potential. in Pharmaceutics. 2023;15(12):2742. doi:10.3390/pharmaceutics15122742 .
Čutović, Natalija, Marković, Tatjana, Carević, Tamara, Stojković, Dejan, Bugarski, Branko, Jovanović, Aleksandra A., "Liposomal and Liposomes-Film Systems as Carriers for Bioactives from Paeonia tenuifolia L. Petals: Physicochemical Characterization and Biological Potential" in Pharmaceutics, 15, no. 12 (2023):2742, https://doi.org/10.3390/pharmaceutics15122742 . .