The retention behavior of some uracil derivatives in normal and reversed-phase chromatography. Lipophilicity of the compounds
Апстракт
The chromatographic behavior of newly synthesized uracil derivatives has been studied by normal and reversed-phase thin-layer chromatography. Benzene-methanol, benzene-acetonitrile, and benzene-isopropanol were used as mobile phases in normal-phase chromatography and water-methanol and water-acetonitrile in reversed-phase chromatography. The mechanism of retention on different TLC supports was investigated. The retention constants determined for the uracils are discussed in terms of the physicochemical properties of both the solutes and stationary and mobile phases. R-M(0) values derived by extrapolation from reversed-phase chromatography were correlated with the hydrophobicity log P calculated by use of the commercial program ACD/logP. In normal-phase chromatography values for C-0 (= R-M(0/n)) were correlated with the hydrophobicity log P. Good correlation was obtained for both types of chromatography. Retention constants R-M(0) and C-0 can be used to express the lipophilicity of the ...compounds investigated.
Кључне речи:
uracil derivatives / NP TLC / RP HPTLC / C-18 correlation analysis / lipophilicityИзвор:
JPC-Journal of Planar Chromatography-Modern Tlc, 2005, 18, 102, 92-97Издавач:
- Research Inst Medicinal Plants, Budakalasz
DOI: 10.1556/JPC.18.2005.2.1
ISSN: 0933-4173
WoS: 000229721000001
Scopus: 2-s2.0-20444403354
Институција/група
Tehnološko-metalurški fakultetTY - JOUR AU - Perišić-Janjić, Nada AU - Ušćumlić, Gordana AU - Valentić, Nataša PY - 2005 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/824 AB - The chromatographic behavior of newly synthesized uracil derivatives has been studied by normal and reversed-phase thin-layer chromatography. Benzene-methanol, benzene-acetonitrile, and benzene-isopropanol were used as mobile phases in normal-phase chromatography and water-methanol and water-acetonitrile in reversed-phase chromatography. The mechanism of retention on different TLC supports was investigated. The retention constants determined for the uracils are discussed in terms of the physicochemical properties of both the solutes and stationary and mobile phases. R-M(0) values derived by extrapolation from reversed-phase chromatography were correlated with the hydrophobicity log P calculated by use of the commercial program ACD/logP. In normal-phase chromatography values for C-0 (= R-M(0/n)) were correlated with the hydrophobicity log P. Good correlation was obtained for both types of chromatography. Retention constants R-M(0) and C-0 can be used to express the lipophilicity of the compounds investigated. PB - Research Inst Medicinal Plants, Budakalasz T2 - JPC-Journal of Planar Chromatography-Modern Tlc T1 - The retention behavior of some uracil derivatives in normal and reversed-phase chromatography. Lipophilicity of the compounds EP - 97 IS - 102 SP - 92 VL - 18 DO - 10.1556/JPC.18.2005.2.1 ER -
@article{ author = "Perišić-Janjić, Nada and Ušćumlić, Gordana and Valentić, Nataša", year = "2005", abstract = "The chromatographic behavior of newly synthesized uracil derivatives has been studied by normal and reversed-phase thin-layer chromatography. Benzene-methanol, benzene-acetonitrile, and benzene-isopropanol were used as mobile phases in normal-phase chromatography and water-methanol and water-acetonitrile in reversed-phase chromatography. The mechanism of retention on different TLC supports was investigated. The retention constants determined for the uracils are discussed in terms of the physicochemical properties of both the solutes and stationary and mobile phases. R-M(0) values derived by extrapolation from reversed-phase chromatography were correlated with the hydrophobicity log P calculated by use of the commercial program ACD/logP. In normal-phase chromatography values for C-0 (= R-M(0/n)) were correlated with the hydrophobicity log P. Good correlation was obtained for both types of chromatography. Retention constants R-M(0) and C-0 can be used to express the lipophilicity of the compounds investigated.", publisher = "Research Inst Medicinal Plants, Budakalasz", journal = "JPC-Journal of Planar Chromatography-Modern Tlc", title = "The retention behavior of some uracil derivatives in normal and reversed-phase chromatography. Lipophilicity of the compounds", pages = "97-92", number = "102", volume = "18", doi = "10.1556/JPC.18.2005.2.1" }
Perišić-Janjić, N., Ušćumlić, G.,& Valentić, N.. (2005). The retention behavior of some uracil derivatives in normal and reversed-phase chromatography. Lipophilicity of the compounds. in JPC-Journal of Planar Chromatography-Modern Tlc Research Inst Medicinal Plants, Budakalasz., 18(102), 92-97. https://doi.org/10.1556/JPC.18.2005.2.1
Perišić-Janjić N, Ušćumlić G, Valentić N. The retention behavior of some uracil derivatives in normal and reversed-phase chromatography. Lipophilicity of the compounds. in JPC-Journal of Planar Chromatography-Modern Tlc. 2005;18(102):92-97. doi:10.1556/JPC.18.2005.2.1 .
Perišić-Janjić, Nada, Ušćumlić, Gordana, Valentić, Nataša, "The retention behavior of some uracil derivatives in normal and reversed-phase chromatography. Lipophilicity of the compounds" in JPC-Journal of Planar Chromatography-Modern Tlc, 18, no. 102 (2005):92-97, https://doi.org/10.1556/JPC.18.2005.2.1 . .