Chromatophore based cytosensor: Responses to various biologically active agents
Citosenzor na bazi hromatofora - ispitivanje odgovora različitih biološki aktivnih agenasa
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The design, operation and performances of a cytosensor based on immobilized living chromatophores isolated from Betta splendens Siamese fighting fish are presented in this paper. Development of the cell immobilization technique as an important cytosensor enabling technology, and integration of the immobilized cells in the cytosensor system is described. The cytosensor was used to test several classes of biologically active agents including neurotransmitters, adenyl cyclase activators, cytoskeleton effectors, cell membrane effectors, and protein synthesis inhibitors and the obtained responses were analyzed. Particular response features such as mode of response, its magnitude, kinetics, sensitivity and dose dependence were monitored and may be used as a basis for mathematical modeling of the responses. The results indicated that the cytosensor has great potential for use in food and water testing and in pharmacy.
U radu je prikazan dizajn, način rada i karakteristike citosenzora na bazi imobilisanih hromatofora izolovanih iz vrste ribe Betta splendens, Sijamski borac. Ispitana je i razvijena tehnika imobilizacije ovih ćelija, koja predstavlja jednu od ključnih pomoćnih tehnologija na kojima se bazira funkcionisanje citosenzora, kao i uslovi potrebni da bi se imobilisane ćelije integrisale u mikroreaktor senzora. Ispitani su odgovori citosenzora na širok spektar biološki aktivnih agenasa koji uključuju: neurotransmitere aktivatore adenil ciklaze, agense koji deluju na ćelijski skeleton inhibitore sinteze proteina i agense koji deluju na ćelijsku membranu. Praćene su, analizirane i upoređene sledeće karakteristike odgovora hromatofora na ove agense: način odgovora, jačina odgovora, kinetika senzitivnost i zavisnost odgovora od koncentracije agensa. Na osnovu ovih karakteristika moguće je vršiti njihovo modelovanje i klasifikaciju. Rezultati su pokazali da je citosenzor pogodan za korišćenje u kon...troli vode i hrane, zagađenja okoline, kao i u farmaceutske svrhe.
Кључне речи:
fish chromatophores / cytosensor / biologically active agents / hromatofore riba / citosenzor / biološki aktivni agensiИзвор:
Chemical Industry & Chemical Engineering Quarterly, 2006, 12, 1, 63-70Издавач:
- Association of the Chemical Engineers of Serbia
Институција/група
Tehnološko-metalurški fakultetTY - JOUR AU - Mojović, Ljiljana AU - Dierksen, Karen AU - Jovanović, Goran N. PY - 2006 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/941 AB - The design, operation and performances of a cytosensor based on immobilized living chromatophores isolated from Betta splendens Siamese fighting fish are presented in this paper. Development of the cell immobilization technique as an important cytosensor enabling technology, and integration of the immobilized cells in the cytosensor system is described. The cytosensor was used to test several classes of biologically active agents including neurotransmitters, adenyl cyclase activators, cytoskeleton effectors, cell membrane effectors, and protein synthesis inhibitors and the obtained responses were analyzed. Particular response features such as mode of response, its magnitude, kinetics, sensitivity and dose dependence were monitored and may be used as a basis for mathematical modeling of the responses. The results indicated that the cytosensor has great potential for use in food and water testing and in pharmacy. AB - U radu je prikazan dizajn, način rada i karakteristike citosenzora na bazi imobilisanih hromatofora izolovanih iz vrste ribe Betta splendens, Sijamski borac. Ispitana je i razvijena tehnika imobilizacije ovih ćelija, koja predstavlja jednu od ključnih pomoćnih tehnologija na kojima se bazira funkcionisanje citosenzora, kao i uslovi potrebni da bi se imobilisane ćelije integrisale u mikroreaktor senzora. Ispitani su odgovori citosenzora na širok spektar biološki aktivnih agenasa koji uključuju: neurotransmitere aktivatore adenil ciklaze, agense koji deluju na ćelijski skeleton inhibitore sinteze proteina i agense koji deluju na ćelijsku membranu. Praćene su, analizirane i upoređene sledeće karakteristike odgovora hromatofora na ove agense: način odgovora, jačina odgovora, kinetika senzitivnost i zavisnost odgovora od koncentracije agensa. Na osnovu ovih karakteristika moguće je vršiti njihovo modelovanje i klasifikaciju. Rezultati su pokazali da je citosenzor pogodan za korišćenje u kontroli vode i hrane, zagađenja okoline, kao i u farmaceutske svrhe. PB - Association of the Chemical Engineers of Serbia T2 - Chemical Industry & Chemical Engineering Quarterly T1 - Chromatophore based cytosensor: Responses to various biologically active agents T1 - Citosenzor na bazi hromatofora - ispitivanje odgovora različitih biološki aktivnih agenasa EP - 70 IS - 1 SP - 63 VL - 12 DO - 10.2298/CICEQ0601063M ER -
@article{ author = "Mojović, Ljiljana and Dierksen, Karen and Jovanović, Goran N.", year = "2006", abstract = "The design, operation and performances of a cytosensor based on immobilized living chromatophores isolated from Betta splendens Siamese fighting fish are presented in this paper. Development of the cell immobilization technique as an important cytosensor enabling technology, and integration of the immobilized cells in the cytosensor system is described. The cytosensor was used to test several classes of biologically active agents including neurotransmitters, adenyl cyclase activators, cytoskeleton effectors, cell membrane effectors, and protein synthesis inhibitors and the obtained responses were analyzed. Particular response features such as mode of response, its magnitude, kinetics, sensitivity and dose dependence were monitored and may be used as a basis for mathematical modeling of the responses. The results indicated that the cytosensor has great potential for use in food and water testing and in pharmacy., U radu je prikazan dizajn, način rada i karakteristike citosenzora na bazi imobilisanih hromatofora izolovanih iz vrste ribe Betta splendens, Sijamski borac. Ispitana je i razvijena tehnika imobilizacije ovih ćelija, koja predstavlja jednu od ključnih pomoćnih tehnologija na kojima se bazira funkcionisanje citosenzora, kao i uslovi potrebni da bi se imobilisane ćelije integrisale u mikroreaktor senzora. Ispitani su odgovori citosenzora na širok spektar biološki aktivnih agenasa koji uključuju: neurotransmitere aktivatore adenil ciklaze, agense koji deluju na ćelijski skeleton inhibitore sinteze proteina i agense koji deluju na ćelijsku membranu. Praćene su, analizirane i upoređene sledeće karakteristike odgovora hromatofora na ove agense: način odgovora, jačina odgovora, kinetika senzitivnost i zavisnost odgovora od koncentracije agensa. Na osnovu ovih karakteristika moguće je vršiti njihovo modelovanje i klasifikaciju. Rezultati su pokazali da je citosenzor pogodan za korišćenje u kontroli vode i hrane, zagađenja okoline, kao i u farmaceutske svrhe.", publisher = "Association of the Chemical Engineers of Serbia", journal = "Chemical Industry & Chemical Engineering Quarterly", title = "Chromatophore based cytosensor: Responses to various biologically active agents, Citosenzor na bazi hromatofora - ispitivanje odgovora različitih biološki aktivnih agenasa", pages = "70-63", number = "1", volume = "12", doi = "10.2298/CICEQ0601063M" }
Mojović, L., Dierksen, K.,& Jovanović, G. N.. (2006). Chromatophore based cytosensor: Responses to various biologically active agents. in Chemical Industry & Chemical Engineering Quarterly Association of the Chemical Engineers of Serbia., 12(1), 63-70. https://doi.org/10.2298/CICEQ0601063M
Mojović L, Dierksen K, Jovanović GN. Chromatophore based cytosensor: Responses to various biologically active agents. in Chemical Industry & Chemical Engineering Quarterly. 2006;12(1):63-70. doi:10.2298/CICEQ0601063M .
Mojović, Ljiljana, Dierksen, Karen, Jovanović, Goran N., "Chromatophore based cytosensor: Responses to various biologically active agents" in Chemical Industry & Chemical Engineering Quarterly, 12, no. 1 (2006):63-70, https://doi.org/10.2298/CICEQ0601063M . .