The investigation is based upon recent research in the area of the synthesis of biodegradable poly(L-lactide) (PLLA) for biomedical applications using stannous octoate (SnOct) as an initiator. The objective was to investigate factors that affect the synthesis of poly(L-lactide), such as monomer purification, vacuum required for monomer drying, polymerization reacton time and catalyst concentration. Complete polymer characterization was done by 1H-NMR, IR spectroscopy and light scattering, in order to reveal the polymerization mechanism. An attempt was made to obtain a polymer of high molecular weight and good mechanical properties that could be used for the processing of biodegradable surgical sutures. Experiments showed that the optimum conditions to obtain polymer of high molecular weight (≈ 30 × 104) are: vacuum required for monomer drying (0.2 mmHg), purification of both monomer and polymer by recrystallization/precipitation, monomer/initiator mole ratio ([M]/[I] about 5000 and a p...olymerization time of approximately 50 h.
Keywords:
Biodegradable polymers / Medical applications / Poly-L-actide synthesis
Source:
Journal of the Serbian Chemical Society, 1996, 61, 4-5, 311-318
TY - JOUR
AU - Ristić, C.
AU - Plavšić, Milenko B.
AU - Goosen, M.F.
AU - Sajc, L.
AU - Antonović, Dušan
AU - Bugarski, Branko
PY - 1996
UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/100
AB - The investigation is based upon recent research in the area of the synthesis of biodegradable poly(L-lactide) (PLLA) for biomedical applications using stannous octoate (SnOct) as an initiator. The objective was to investigate factors that affect the synthesis of poly(L-lactide), such as monomer purification, vacuum required for monomer drying, polymerization reacton time and catalyst concentration. Complete polymer characterization was done by 1H-NMR, IR spectroscopy and light scattering, in order to reveal the polymerization mechanism. An attempt was made to obtain a polymer of high molecular weight and good mechanical properties that could be used for the processing of biodegradable surgical sutures. Experiments showed that the optimum conditions to obtain polymer of high molecular weight (≈ 30 × 104) are: vacuum required for monomer drying (0.2 mmHg), purification of both monomer and polymer by recrystallization/precipitation, monomer/initiator mole ratio ([M]/[I] about 5000 and a polymerization time of approximately 50 h.
PB - Serbian Chemical Society, Belgrade
T2 - Journal of the Serbian Chemical Society
T1 - An investigation of the synthesis of poly(L-lactide) as a biodegradable polymer for orthopaedic applications
EP - 318
IS - 4-5
SP - 311
VL - 61
UR - https://hdl.handle.net/21.15107/rcub_technorep_100
ER -
@article{
author = "Ristić, C. and Plavšić, Milenko B. and Goosen, M.F. and Sajc, L. and Antonović, Dušan and Bugarski, Branko",
year = "1996",
abstract = "The investigation is based upon recent research in the area of the synthesis of biodegradable poly(L-lactide) (PLLA) for biomedical applications using stannous octoate (SnOct) as an initiator. The objective was to investigate factors that affect the synthesis of poly(L-lactide), such as monomer purification, vacuum required for monomer drying, polymerization reacton time and catalyst concentration. Complete polymer characterization was done by 1H-NMR, IR spectroscopy and light scattering, in order to reveal the polymerization mechanism. An attempt was made to obtain a polymer of high molecular weight and good mechanical properties that could be used for the processing of biodegradable surgical sutures. Experiments showed that the optimum conditions to obtain polymer of high molecular weight (≈ 30 × 104) are: vacuum required for monomer drying (0.2 mmHg), purification of both monomer and polymer by recrystallization/precipitation, monomer/initiator mole ratio ([M]/[I] about 5000 and a polymerization time of approximately 50 h.",
publisher = "Serbian Chemical Society, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "An investigation of the synthesis of poly(L-lactide) as a biodegradable polymer for orthopaedic applications",
pages = "318-311",
number = "4-5",
volume = "61",
url = "https://hdl.handle.net/21.15107/rcub_technorep_100"
}
Ristić, C., Plavšić, M. B., Goosen, M.F., Sajc, L., Antonović, D.,& Bugarski, B.. (1996). An investigation of the synthesis of poly(L-lactide) as a biodegradable polymer for orthopaedic applications. in Journal of the Serbian Chemical Society
Serbian Chemical Society, Belgrade., 61(4-5), 311-318.
https://hdl.handle.net/21.15107/rcub_technorep_100
Ristić C, Plavšić MB, Goosen M, Sajc L, Antonović D, Bugarski B. An investigation of the synthesis of poly(L-lactide) as a biodegradable polymer for orthopaedic applications. in Journal of the Serbian Chemical Society. 1996;61(4-5):311-318.
https://hdl.handle.net/21.15107/rcub_technorep_100 .
Ristić, C., Plavšić, Milenko B., Goosen, M.F., Sajc, L., Antonović, Dušan, Bugarski, Branko, "An investigation of the synthesis of poly(L-lactide) as a biodegradable polymer for orthopaedic applications" in Journal of the Serbian Chemical Society, 61, no. 4-5 (1996):311-318,
https://hdl.handle.net/21.15107/rcub_technorep_100 .
