Controlled release studies of drugs (theophylline (TH), fenethylline hydrochloride (FE) and gentamicin sulphate (GS)) from pH sensitive poly(2-hydroxyethyl methacrylate/itaconic acid) (P(HEMA/IA)) hydrogels obtained by gamma irradiation were carried out to investigate transport phenomena. Drug behavior and release profiles were analyzed using the restriction coefficient combining the influence of network structure and the size of the drug on release and transport properties. The results demonstrated that the ratio of drug radius to polymer pore size and drugpolymer interactions were dominant factors in hindering the diffusion process. The diffusivity of a drug through the hydrogels decreases with the size of the drug molecules and with the decrease in gel pore size. The diffusion equations for used drugs explain drug transport in hydrogels.
TY - JOUR
AU - Mićić, Maja M.
AU - Tomić, Simonida
AU - Filipović, Jovanka M.
AU - Suljovrujić, Edin H.
PY - 2007
UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1019
AB - Controlled release studies of drugs (theophylline (TH), fenethylline hydrochloride (FE) and gentamicin sulphate (GS)) from pH sensitive poly(2-hydroxyethyl methacrylate/itaconic acid) (P(HEMA/IA)) hydrogels obtained by gamma irradiation were carried out to investigate transport phenomena. Drug behavior and release profiles were analyzed using the restriction coefficient combining the influence of network structure and the size of the drug on release and transport properties. The results demonstrated that the ratio of drug radius to polymer pore size and drugpolymer interactions were dominant factors in hindering the diffusion process. The diffusivity of a drug through the hydrogels decreases with the size of the drug molecules and with the decrease in gel pore size. The diffusion equations for used drugs explain drug transport in hydrogels.
PB - 8th Conference of the Yugoslav Materials Research Society
T2 - Materials Science Forum
T1 - Release and diffusion studies of hydrogels based on itaconic acid
EP - 446
SP - 441
VL - 555
DO - 10.4028/0-87849-441-3.441
ER -
@article{
author = "Mićić, Maja M. and Tomić, Simonida and Filipović, Jovanka M. and Suljovrujić, Edin H.",
year = "2007",
abstract = "Controlled release studies of drugs (theophylline (TH), fenethylline hydrochloride (FE) and gentamicin sulphate (GS)) from pH sensitive poly(2-hydroxyethyl methacrylate/itaconic acid) (P(HEMA/IA)) hydrogels obtained by gamma irradiation were carried out to investigate transport phenomena. Drug behavior and release profiles were analyzed using the restriction coefficient combining the influence of network structure and the size of the drug on release and transport properties. The results demonstrated that the ratio of drug radius to polymer pore size and drugpolymer interactions were dominant factors in hindering the diffusion process. The diffusivity of a drug through the hydrogels decreases with the size of the drug molecules and with the decrease in gel pore size. The diffusion equations for used drugs explain drug transport in hydrogels.",
publisher = "8th Conference of the Yugoslav Materials Research Society",
journal = "Materials Science Forum",
title = "Release and diffusion studies of hydrogels based on itaconic acid",
pages = "446-441",
volume = "555",
doi = "10.4028/0-87849-441-3.441"
}
Mićić, M. M., Tomić, S., Filipović, J. M.,& Suljovrujić, E. H.. (2007). Release and diffusion studies of hydrogels based on itaconic acid. in Materials Science Forum
8th Conference of the Yugoslav Materials Research Society., 555, 441-446.
https://doi.org/10.4028/0-87849-441-3.441
Mićić MM, Tomić S, Filipović JM, Suljovrujić EH. Release and diffusion studies of hydrogels based on itaconic acid. in Materials Science Forum. 2007;555:441-446.
doi:10.4028/0-87849-441-3.441 .
Mićić, Maja M., Tomić, Simonida, Filipović, Jovanka M., Suljovrujić, Edin H., "Release and diffusion studies of hydrogels based on itaconic acid" in Materials Science Forum, 555 (2007):441-446,
https://doi.org/10.4028/0-87849-441-3.441 . .
